{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:18Z","timestamp":1786650078130,"version":"build-2736575974"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Vascular hypotheses was previously considered to play a major role in pathophysiology of migraine. Recently, neurological mechanisms have been proposed with implication of the trigemino-vascular pathway. Deciphering the pathophysiology of this disorder is extremely important for diagnosis, assessment of progression and to explore targeted treatment options.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To assess white matter alterations in patients of migraine by using Diffusion Tensor Imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We performed Diffusion Tensor Imaging in migraine patients to assess changes in microstructural integrity of white matter tracts involved in pain processing to localize the tracts involved in migraine. This is a cross-sectional observational study involving 50 subjects (30 patients of migraine diagnosed as per ICHD-III and 20 age and sex matched controls). DTI was performed on 3T MRI and the mean diffusivity and fractional anisotropy values of the cases were compared with controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Conslusion:<\/jats:title>\n                    <jats:p>Significant changes were noted in the multiple white matter tracts implicated in pain processing compared to the controls. Significant association was also noted between the DTI parameters and the type and frequency of migraine. DTI can thus assist in the diagnosis, assessing the extent of neurological damage in patients of migraine and follow up post treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ni.ni_894_22","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T04:00:50Z","timestamp":1734494450000},"page":"1169-1173","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of White Matter Alterations in Patients of Migraine Using Diffusion Tensor Imaging"],"prefix":"10.4103","volume":"72","author":[{"given":"Civilee","family":"Nanda","sequence":"first","affiliation":[{"name":"Department of Radiodiagnosis, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namrita","family":"Sachdev","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"R2-20260424","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/S1474-4422(18)30322-3","article-title":"Global, regional, and national burden of migraine and tension-type headache, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016","volume":"17","author":"Stovner","year":"2018","journal-title":"Lancet Neurol"},{"key":"R3-20260424","doi-asserted-by":"crossref","first-page":"67.","DOI":"10.1186\/s10194-015-0549-x","article-title":"Headache disorders and public ill-health in India: Prevalence estimates in Karnataka State","volume":"16","author":"Kulkarni","year":"2015","journal-title":"J Headache Pain"},{"issue":"1 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white-matter tract integrity: A diffusion-tensor imaging study","volume":"35","author":"Chong","year":"2015","journal-title":"Cephalalgia"},{"key":"R9-20260424","doi-asserted-by":"crossref","first-page":"92.","DOI":"10.1186\/s10194-020-01159-6","article-title":"Patients with chronic migraine without history of medication overuse are characterized by a peculiar white matter fiber bundle profile","volume":"21","author":"Coppola","year":"2020","journal-title":"J Headache Pain"},{"key":"R10-20260424","article-title":"Changes in white-matter tracts between episodic and chronic migraine using diffusion-tensor imaging (DTI): Preliminary findings","author":"Marsecano","year":"2018"},{"key":"R11-20260424","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1177\/0333102412466964","article-title":"Axonal loss of white matter in migraine without aura: A tract-based spatial statistics study","volume":"33","author":"Yu","year":"2013","journal-title":"Cephalalgia"},{"key":"R12-20260424","doi-asserted-by":"crossref","first-page":"e45476","DOI":"10.1371\/journal.pone.0045476","article-title":"Reduced fractional anisotropy of corpus callosum modulates inter-hemispheric resting state functional connectivity in migraine patients without aura","volume":"7","author":"Yuan","year":"2012","journal-title":"PLoS One"},{"key":"R13-20260424","first-page":"301","article-title":"Interictal alterations of the trigeminal somatosensory pathway and periaqueductal gray matter in migraine","volume":"18","author":"DaSilva","year":"2007","journal-title":"Neuro Report"},{"key":"R14-20260424","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1148\/radiol.2301021640","article-title":"Fiber tract-based atlas of human white matter anatomy","volume":"230","author":"Wakana","year":"2004","journal-title":"Radiology"},{"key":"R15-20260424","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.clineuro.2018.09.022","article-title":"White matter diffusion abnormalities in migraine and medication overuse headache: A 1.5-T tract-based spatial statistics study","volume":"174","author":"Shibata","year":"2018","journal-title":"Clin Neurol Neurosurg"},{"key":"R16-20260424","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1001\/jama.291.4.427","article-title":"Migraine as a risk factor for subclinical brain lesions","volume":"291","author":"Kruit","year":"2004","journal-title":"JAMA"}],"container-title":["Neurology 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