{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:34:03Z","timestamp":1787758443275,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Despite its extensive bone resorption and high recurrence rate, marsupialization is the preferred option in the treatment of odontogenic keratocysts (OKCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>We aimed to assess the effect of marsupialization on histomorphological and biochemical markers of OKCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The study is conducted on 48 paraffin blocks of 24 OKC cases between the years 2012 to 2018. The main clinical, radiographic, and histomorphometric measurements were recorded. Immunohistochemical staining with E-cadherin, Ki67, IL1\u03b1, TNF\u03b1, Slug, and Snail were performed and compared for pre-marsupialization and post-marsupialization values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      OKCs mostly located in the mandibular posterior region. The mean marsupialization period was 8.8 \u00b1 6.5 (3-25) months. The mean radiographic size of OKC (57.1 \u00b1 53.5 mm) was significantly reduced after marsupialization (22.6 \u00b1 19.9 mm,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002). Histologically, significantly increased thickness of the OKC epithelium (p = 0.002) and collagen production (p = 0.034) was detected after marsupialization. The post-marsupialization group showed positive correlation of inflammation score to both TNF\u03b1 (r: 0.69,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and IL-1\u03b1 (r: 0.58,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.008) expressions in connective tissue. Among immunohistochemical parameters, only Slug expression was significantly higher after marsupialization (p = 0.019).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study suggests that increased Slug expression may enable the second surgery by increasing fibrosis in the cyst wall.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_103_22","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T13:57:08Z","timestamp":1663855028000},"page":"1548-1556","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Investigation of the Effects of Marsupialization on Histomorphological and Immunohistochemical Markers of Odontogenic Keratocysts"],"prefix":"10.4103","volume":"25","author":[{"given":"E","family":"Bar\u0131\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I Atak","family":"Se\u00e7en","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015e","family":"Karabulut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SE","family":"G\u00fcltekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-25-20240907","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.humpath.2017.05.014","article-title":"The fourth edition of the head and neck World Health Organization blue book: Editors' perspectives","volume":"66","author":"El-Naggar","year":"2017","journal-title":"Hum 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