{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:05:16Z","timestamp":1787169916903,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,2]]},"abstract":"\n Background:<\/jats:title>\n Timing of laparoscopic cholecystectomy (LC) in acute cholecystitis (AC) is still debated.<\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n The aim of this study was to investigate the effect of timing on operative results; from the first appearance of symptoms to the operation.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n The study included 57 sequential patients operated laparoscopically for AC. Patients operated within the first 3 days of admission (Group 1), those operated between 4\n th<\/jats:sup>\n and 7\n th<\/jats:sup>\n days (Group 2) and those operated after 7\n th<\/jats:sup>\n day (Group 3) were evaluated and compared with respect to demographics, time from admission to operation, duration of operation, adhesion score, complications, conversion rates, duration of hospital stay, morbidity and mortality rates, bile culture results, and histopathological evaluation.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n A total of 63% of the patients were female and 21 (37%) were male. The mean age was 48 years (range, 21\u201374). There was no significant difference among the groups with respect to demographics (\n P<\/jats:italic>\n > 0.05, for each). The duration of operation was significantly shorter in Group 1 than both Groups 2 and 3 (\n P<\/jats:italic>\n < 0.05 and\n P<\/jats:italic>\n < 0.001, respectively). Duration of operation was also significantly shorter in Group 2 than Group 3 (\n P<\/jats:italic>\n < 0.001). Group 1 had significantly fewer adhesions compared to Group 2 and Group 3 (\n P<\/jats:italic>\n < 0.05 and\n P<\/jats:italic>\n < 0.001, respectively), and no significant difference was found between Group 2 and Group 3 (\n P<\/jats:italic>\n > 0.05). Duration of hospital stay was significantly shorter in Group 1 compared to Group 2 and Group 3 (\n P<\/jats:italic>\n < 0.001) and also was significantly shorter in Group 2 than Group 3 (\n P<\/jats:italic>\n < 0.05). Group 1 had significantly lower rate of culture proliferation than Group 3 (\n P<\/jats:italic>\n < 0.001), whereas no significant differences were evident in other inter-group analyses (\n P<\/jats:italic>\n > 0.05, for each).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n LC can safely be performed within 7 days of admission in cases of AC.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/njcp.njcp_138_20","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T02:55:50Z","timestamp":1692586550000},"page":"156-160","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Timing of Laparoscopic Cholecystectomy in Acute Cholecystitis"],"prefix":"10.4103","volume":"24","author":[{"given":"S","family":"Yuksekdag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Bas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Okan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Karakelleoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Alimoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Akcakaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-3-20240907","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1007\/s10620-006-9107-3","article-title":"Asymptomatic cholelithiasis: Is cholecystectomy really needed? A critical reappraisal 15 years after the introduction of laparoscopic cholecystectomy","volume":"52","author":"Sakorafas","year":"2007","journal-title":"Dig Dis Sci"},{"key":"R2-3-20240907","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3949\/ccjm.85a.17035","article-title":"Gallstones: Watch and wait, or intervene?","volume":"85","author":"Ibrahim","year":"2018","journal-title":"Cleve Clin J Med"},{"key":"R3-3-20240907","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00534-005-1095-8","article-title":"Timing of laparoscopic cholecystectomy for subacute calculous cholecystitis: Early or interval-a prospective study","volume":"13","author":"Y\u00fcksel","year":"2006","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"R4-3-20240907","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/bjs5.50120","article-title":"Meta-analysis of the cost-effectiveness of early versus delayed cholecystectomy for acute cholecystitis","volume":"3","author":"Gallagher","year":"2019","journal-title":"BJS Open"},{"key":"R5-3-20240907","first-page":"71","article-title":"A diagnostic score to predict the difficulty of a laparoscopic cholecystectomy for early cholecystitis","volume":"13","author":"Schrenh","year":"1998","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"key":"R6-3-20240907","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1136\/bmj.305.6850.394","article-title":"Laparoscopic cholecystectomy as a safe and effective treatment for severe acute cholecystitis","volume":"305","author":"Wilson","year":"1992","journal-title":"Br Med J"},{"key":"R7-3-20240907","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13017-019-0285-7","article-title":"Timing of early laparoscopic cholecystectomy for acute calculous cholecystitis revised: Protocol of a systematic review and meta-analysis of results","volume":"15","author":"Borzellino","year":"2020","journal-title":"World J Emerg Surg"},{"key":"R8-3-20240907","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1111\/ans.15493","article-title":"Predicting operative difficulty of laparoscopic cholecystectomy in patients with acute biliary presentations","volume":"89","author":"Wennmacker","year":"2019","journal-title":"ANZ J Surg"},{"key":"R9-3-20240907","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1001\/archsurg.1974.01350300081019","article-title":"Role of proteolytic enzyme in the prevention of postoperative intraperitoneal adhesions","volume":"108","author":"Nair","year":"1974","journal-title":"Arch Surg"},{"key":"R10-3-20240907","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1089\/lap.2005.15.130","article-title":"The effect of the degree of histologic inflammation on gallbladder perforation during laparoscopic cholecystectomy","volume":"15","author":"Bas","year":"2005","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"R11-3-20240907","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00595-005-2998-3","article-title":"Early versus delayed cholecystectomy for acute cholecystitis: A meta-analysis of randomized controlled trials","volume":"35","author":"Shikata","year":"2005","journal-title":"Surg Today"},{"key":"R12-3-20240907","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1097\/SLA.0000000000001886","article-title":"Early versus delayed cholecystectomy for acute cholecystitis, are the 72 hours still the rule?: A randomized trial","volume":"264","author":"Roulin","year":"2016","journal-title":"Ann Surg"},{"key":"R13-3-20240907","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s004640020088","article-title":"Laparoscopic cholecystectomy in acute cholecystitis. A prospective comparative study in patients with acute vs. chronic cholecystitis","volume":"14","author":"Pessaux","year":"2000","journal-title":"Surg Endosc"},{"key":"R14-3-20240907","doi-asserted-by":"crossref","first-page":"414","DOI":"10.4103\/1947-2714.115783","article-title":"Comparison of early and delayed laparoscopic cholecystectomy for cholecystitis","volume":"5","author":"Rouf","year":"2013","journal-title":"N Am J Med Sci"},{"key":"R15-3-20240907","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1097\/SLA.0b013e318228d31c","article-title":"Population-based analysis of 4113 patients with acute cholecystitis: defining the optimal time- point for laparoscopic cholecystectomy","volume":"254","author":"Banz","year":"2011","journal-title":"Ann Surg"},{"key":"R16-3-20240907","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/TA.0b013e3182788b71","article-title":"No need to wait: An analysis of the timing of cholecystectomy during admission for acute cholecystitis using the American College of Surgeons National Surgical Quality Improvement Program database","volume":"74","author":"Brooks","year":"2013","journal-title":"J Trauma Acute Care Surg"},{"key":"R17-3-20240907","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1007\/s00464-009-0374-x","article-title":"Laparoscopic cholecystectomy for acute cholecystitis: Safe implementation of successful strategies to reduce conversion rates","volume":"23","author":"Low","year":"2009","journal-title":"Surg Endosc"},{"key":"R18-3-20240907","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1089\/lap.2005.15.379","article-title":"Laparoscopic cholecystectomy in the elderly: \u0130ncreased operative complication and conversion to laparotomy","volume":"15","author":"Kauvar","year":"2005","journal-title":"Laparoendosc Adv Tech A"}],"container-title":["Nigerian Journal of Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/njcp.njcp_138_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:14:55Z","timestamp":1787166895000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/njcp.njcp_138_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/njcp.njcp_138_20","relation":{},"ISSN":["1119-3077"],"issn-type":[{"value":"1119-3077","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}