{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:33:49Z","timestamp":1786649629360,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Retinopathy of prematurity (ROP) causes blindness among children, particularly preterm infants. While several screening models exist, their performance in developing countries is not well established. This study assessed the accuracy of Children\u2019s Hospital of Philadelphia-Retinopathy of Prematurity (CHOP-ROP) in Saudi Arabia and compared it with other models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the diagnostic performance of the CHOP-ROP model in Saudi preterm infants and compare it with other ROP screening tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective study involving 524 preterm infants was conducted in two tertiary hospitals in Jeddah. ROP risk was assessed using the CHOP-ROP and compared with four ROP risk models. Predictive values, specificity, sensitivity, and receiver operating characteristic curves were analyzed. Logistic regression identified type 1 ROP predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Any-stage ROP was detected in 22.3% of infants; 9.1% required treatment. CHOP-ROP had the highest specificity (62.5%), accuracy (64.2%), and area under the curve (AUC) (0.71), indicating better ability to distinguish infants needing treatment, though its sensitivity was lower (81.4%) than other models. Lower birth weight, longer neonatal intensive care unit stay, and early blood transfusion were significant type 1 ROP predictors (all,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although CHOP-ROP demonstrated strong specificity and accuracy, its lower sensitivity raises concerns about missed cases requiring treatment. Compared to more sensitive local tools, its performance was suboptimal. Region-specific model validation and threshold adjustments are needed to enhance its predictive value while minimizing false negatives.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_138_25","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T04:00:15Z","timestamp":1753675215000},"page":"783-789","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of the Children\u2019s Hospital of Philadelphia Score Algorithm for Screening Retinopathy of Prematurity in Premature Infants in Saudi Arabia"],"prefix":"10.4103","volume":"28","author":[{"given":"LH","family":"Raffa","sequence":"first","affiliation":[{"name":"Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"},{"name":"Department of Ophthalmology, King Abdulaziz University Hospital, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Bawajeeh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RA","family":"Alothman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HS","family":"Almarzouki","sequence":"additional","affiliation":[{"name":"College of Medicine and Research Center, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia"},{"name":"King Abdullah International Medical Research Center, Ministry of National Guard Health Affairs, Western 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