{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:39:58Z","timestamp":1787071198198,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The comorbidity, coheritability and common immune pathways of the inflammatory \u2018chronic\u2019 (non-communicable) diseases, suggest a shared aetiopathogenic mechanism, with phenotypic localization dependent on genetic predisposition, for example, the arteries in hypertension and the skin in psoriasis. Lifelong observation of psoriasis suggests genetically predisposed toxicity of amphiphilic fats, flavor enhancers, and nonsugar sweeteners.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To conduct trials of personalized dietary intervention to abate the phenotypic expression of psoriasis and hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The interventional case study of psoriasis was conducted by means of repetitive dietary challenge and avoidance testing. We then conducted an open trial of personalized nutrition on nine consenting recruits with uncomplicated essential hypertension. They were counseled on which foods to avoid or to take based on the experience gained in psoriasis. Study participants with \u2018GOOD\u2019 or \u2018FAIR\/POOR\u2019 dietary compliance were compared with regard to blood pressure (BP) control, antihypertensive drug treatment requirement (ADTR), and anthropometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Data from four FAIR\/POOR diet compliers and three GOOD compliers, as at 29 weeks of dietary intervention, showed mean systolic home B\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      values of 128.1 (\u00b16.74) mmHg and 122.3 (\u00b12.03) mmHg, respectively; the mean systolic automated office B\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      values were 139.8 (\u00b18.80) mmHg and 108.3 (\u00b15.55) mmHg, respectively; as at 39 weeks of dietary intervention, the mean ADTR scores were 4.2 (\u00b12.12) and 1.03 (\u00b10.57), respectively. Using data at baseline and from all available timepoints after dietary intervention, two-way ANOVA confirmed highly significant improvement of BP control (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001) and reduction of ADTR score (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0008) in GOOD compliers. GOOD compliers exhibited significantly more reductions in BMI, abdominal circumference, and triceps skinfold thickness than FAIR\/POOR compliers (two-way ANOVA and linear regression:\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These results support the case for adverse dietary exposure avoidance to abate the phenotypic expression of chronic disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_152_24","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T23:00:41Z","timestamp":1730329241000},"page":"1202-1215","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Personalized Food Avoidance Dietary Approach for Psoriasis and Hypertension: A Case Study and Pilot Trial"],"prefix":"10.4103","volume":"27","author":[{"given":"CP","family":"Chijioke","sequence":"first","affiliation":[{"name":"Departments of Pharmacology & Therapeutics\/ Medicine, College of Medicine, University of Nigeria Enugu Campus, Enugu, Enugu State, Nigeria"},{"name":"Departments of Medicine\/ Human Nutrition & Dietetics, University of Nigeria Teaching Hospital (UNTH), Ituku-Ozalla, Enugu, Enugu State, Nigeria"},{"name":"Dietary Intervention Research Group, Chiolive International Medical Research Organisation, Trans-Ekulu, Enugu, Enugu State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MT","family":"Okafor","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology & Therapeutics\/ Medicine, College of Medicine, University of Nigeria Enugu Campus, Enugu, Enugu State, Nigeria"},{"name":"Dietary Intervention Research Group, Chiolive International Medical Research Organisation, Trans-Ekulu, Enugu, Enugu State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NI","family":"Nubila","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology & Therapeutics\/ Medicine, College of Medicine, University of Nigeria Enugu Campus, Enugu, Enugu State, Nigeria"},{"name":"Dietary Intervention Research Group, Chiolive International Medical Research Organisation, Trans-Ekulu, Enugu, Enugu State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IC","family":"Onah","sequence":"additional","affiliation":[{"name":"Departments of Medicine\/ Human Nutrition & Dietetics, University of Nigeria Teaching Hospital (UNTH), Ituku-Ozalla, Enugu, Enugu State, Nigeria"},{"name":"Dietary Intervention Research Group, Chiolive International Medical Research Organisation, Trans-Ekulu, Enugu, Enugu State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"UO","family":"Chijioke","sequence":"additional","affiliation":[{"name":"Dietary Intervention Research Group, Chiolive International Medical Research Organisation, Trans-Ekulu, Enugu, Enugu State, Nigeria"},{"name":"Department of Health Administration and Management, University of Nigeria Enugu Campus, Enugu, Enugu State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NN","family":"Chigbo","sequence":"additional","affiliation":[{"name":"Departments of Medicine\/ Human Nutrition & Dietetics, University of Nigeria Teaching Hospital (UNTH), Ituku-Ozalla, Enugu, Enugu State, Nigeria"},{"name":"Dietary Intervention Research Group, Chiolive International Medical Research Organisation, Trans-Ekulu, Enugu, Enugu State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IC","family":"Maduka","sequence":"additional","affiliation":[{"name":"College of Health Science, Nnamdi Azikiwe University, Awka, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IP","family":"Udoh","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology & Therapeutics\/ Medicine, College of Medicine, University of Nigeria Enugu Campus, Enugu, Enugu State, Nigeria"},{"name":"Dietary Intervention Research Group, Chiolive International Medical Research Organisation, Trans-Ekulu, Enugu, Enugu State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CI","family":"Eleazar","sequence":"additional","affiliation":[{"name":"Dietary Intervention Research Group, Chiolive International Medical Research Organisation, Trans-Ekulu, Enugu, Enugu State, Nigeria"},{"name":"Department of Pharmacology & Toxicology, University of Nigeria Nsukka Campus, Nsukka, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NM","family":"Gbenimachor","sequence":"additional","affiliation":[{"name":"Departments of Medicine\/ Human 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