{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:32:14Z","timestamp":1786649534360,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study evaluated orofacial manifestations and oral health-related quality of life in patients with systemic lupus erythematosus (SLE) in the Turkish population. It also aims to investigate the relationship between these findings and disease activity and other associated factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients referred from the rheumatology clinic and SLE-diagnosed patients were evaluated in the oral diagnosis clinic. Orofacial manifestations were assessed through clinical examinations, and oral health status was evaluated using the Decayed-Missing-Filled Teeth (DMFT) index. Disease activity was measured using the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), while oral health-related quality of life was assessed with the Oral Health Impact Profile-14 (OHIP-14). Statistical analyses, including Pearson correlation and Kruskal\u2013Wallis tests, were performed to evaluate associations among disease activity, oral health status, and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The study included 70 SLE patients (67 females, 3 males; mean age: 46.3 \u00b1 13.5 years). Orofacial lesions were present in 25.7% of the patients, and the cheek mucosa was the most commonly affected site. Bruxism was detected in 42.9% of patients, while burning mouth syndrome was observed in 11.4% of patients. Disease activity assessment showed that 45.7% had no activity, and 47.1% had mild severity. The OHIP-14 analysis indicated that psychological discomfort was the most affected domain (2.8 \u00b1 2.26), whereas handicap had the least impact (0.97 \u00b1 1.32). Although significant correlations were found between the OHIP-14 subscales, no significant correlation was observed between SLEDAI-2K scores and OHIP-14 subscales (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Orofacial lesions in SLE patients were relatively common and varied in presentation. Although no direct relationship was found between disease activity and oral health-related quality of life, significant associations existed between different domains of OHIP-14. These findings highlight the need for a multidisciplinary approach to managing oral health in SLE patients to improve their overall quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_166_25","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T01:00:16Z","timestamp":1750813216000},"page":"730-736","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Orofacial Manifestations and Oral Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus"],"prefix":"10.4103","volume":"28","author":[{"given":"F","family":"Akkoca","sequence":"first","affiliation":[{"name":"Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Dokuz Eylul University, \u0130nciralt\u0131, Bal\u00e7ova\/Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Basibuyuk","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, Dokuz Eylul University, \u0130nciralt\u0131, Bal\u00e7ova\/Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Koyuncu","sequence":"additional","affiliation":[{"name":"Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Dokuz Eylul University, \u0130nciralt\u0131, Bal\u00e7ova\/Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Ilhan","sequence":"additional","affiliation":[{"name":"Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Dokuz Eylul University, \u0130nciralt\u0131, Bal\u00e7ova\/Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ME","family":"Arayici","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics, Faculty of Medicine, Dokuz Eylul University, \u0130nciralt\u0131, Bal\u00e7ova\/Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ozdede","sequence":"additional","affiliation":[{"name":"Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Dokuz Eylul University, \u0130nciralt\u0131, Bal\u00e7ova\/Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, Dokuz Eylul University, \u0130nciralt\u0131, Bal\u00e7ova\/Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"R1-20260422","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/acr.20572","article-title":"Measures of adult systemic lupus erythematosus: Updated Version of British Isles Lupus Assessment Group (BILAG 2004), European Consensus Lupus Activity Measurements (ECLAM), Systemic Lupus Activity Measure, Revised (SLAM\u2010R), Systemic Lupus Activity Questionnaire for Population Studies (SLAQ), Systemic Lupus Erythematosus Disease Activity Index2000 (SLEDAI\u20102K), and Systemic Lupus International Collaborating Clinics\/American College of Rheumatology Damage Index (SDI)","volume":"63","author":"Romero\u2010Diaz","year":"2011","journal-title":"Arthritis Care Res"},{"key":"R2-20260422","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nrrheum.2013.103","article-title":"Diagnostic criteria for systemic lupus erythematosus: Has the time come?","volume":"9","author":"Bertsias","year":"2013","journal-title":"Nat Rev Rheumatol"},{"key":"R3-20260422","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJMra071297","article-title":"Systemic lupus erythematosus","volume":"358","author":"Rahman","year":"2008","journal-title":"N Engl J Med"},{"key":"R4-20260422","doi-asserted-by":"crossref","first-page":"101894","DOI":"10.1016\/j.berh.2023.101894","article-title":"Reframing health disparities in SLE: A critical reassessment of racial and ethnic differences in lupus disease outcomes","volume":"37","author":"Parodis","year":"2023","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"R5-20260422","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1177\/0961203316645204","article-title":"A study of the influence of ethnicity on serology and clinical features in lupus","volume":"26","author":"Morais","year":"2017","journal-title":"Lupus"},{"key":"R6-20260422","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s13075-021-02614-8","article-title":"The prevalence of oral mucosal lesions and related factors in systemic lupus erythematosus patients","volume":"23","author":"Kudsi","year":"2021","journal-title":"Arthritis Res Ther"},{"key":"R7-20260422","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1600-0560.2006.00652.x","article-title":"Lupus erythematosus: Clinical and histopathological study of oral manifestations and immunohistochemical profile of the inflammatory infiltrate","volume":"34","author":"Louren\u00e7o","year":"2007","journal-title":"J Cutan Pathol"},{"key":"R8-20260422","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1177\/0961203310383068","article-title":"Squamous cell carcinoma on the palate in a patient with systemic lupus erythematosus: Case report and review of literature","volume":"20","author":"Grimaldo-Carjevschi","year":"2011","journal-title":"Lupus"},{"key":"R9-20260422","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1002\/art.34473","article-title":"Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus","volume":"64","author":"Petri","year":"2012","journal-title":"Arthritis Rheum"},{"key":"R10-20260422","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cden.2004.07.006","article-title":"Oral manifestations of patients with lupus erythematosus","volume":"49","author":"Brennan","year":"2005","journal-title":"Dent Clin North Am"},{"key":"R11-20260422","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1177\/0961203316640909","article-title":"Frequency of dental caries in active and inactive systemic lupus erythematous patients: Salivary and bacterial factors","volume":"25","author":"Rodriguez","year":"2016","journal-title":"Lupus"},{"key":"R12-20260422","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1177\/0961203312454589","article-title":"The prevalence of oral mucosal lesions and related factors in 188 patients with systemic lupus erythematosus","volume":"21","author":"Khatibi","year":"2012","journal-title":"Lupus"},{"key":"R13-20260422","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1034\/j.1600-0722.2002.21363.x","article-title":"The German version of the oral health impact profile \u2013 Translation and psychometric properties","volume":"110","author":"John","year":"2002","journal-title":"Eur J Oral Sci"},{"key":"R14-20260422","first-page":"3","article-title":"Development and evaluation of the oral health impact profile","volume":"11","author":"Slade","year":"1994","journal-title":"Community Dent Health"},{"key":"R15-20260422","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1177\/0961203317719147","article-title":"Impact of systemic lupus erythematosus on oral health-related quality of life","volume":"27","author":"Corr\u00eaa","year":"2018","journal-title":"Lupus"},{"key":"R16-20260422","first-page":"288","article-title":"Systemic lupus erythematosus disease activity inde\u00d72000","volume":"29","author":"Gladman","year":"2002","journal-title":"J Rheumatol"},{"key":"R18-20260422","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/annrheumdis-2020-218272","article-title":"Update \u03bfn the diagnosis and management of systemic lupus erythematosus","volume":"80","author":"Fanouriakis","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"R19-20260422","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1600-0528.1997.tb00941.x","article-title":"Derivation and validation of a short-form oral health impact profile","volume":"25","author":"Slade","year":"1997","journal-title":"Community Dent Oral Epidemiol"},{"key":"R20-20260422","first-page":"85","article-title":"Developing a Turkish oral health impact profile-OHIP-14-TR","volume":"20","author":"Ba\u015fol","year":"2014","journal-title":"Turkiye Klinikleri J Dent Sci"},{"key":"R21-20260422","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.4103\/jfmpc.jfmpc_1263_19","article-title":"Prevalence of oral mucosal lesions, dental caries, and periodontal disease among patients with systemic lupus erythematosus in a teaching hospital in Chennai, Tamil Nadu","volume":"9","author":"Aurlene","year":"2020","journal-title":"J Family Med Prim Care"},{"key":"R22-20260422","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1177\/09612033241252042","article-title":"Oral lesions of systemic lupus erythematosus: A collaborative Latin American study","volume":"33","author":"de Arruda","year":"2024","journal-title":"Lupus"},{"key":"R23-20260422","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/jdv.15980","article-title":"Association between oral lesions and disease activity in lupus erythematosus","volume":"34","author":"Del Barrio-D\u00edaz","year":"2020","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R24-20260422","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.3390\/jcm9041172","article-title":"Oral-health-related quality of life in adult patients with rheumatic diseases \u2013 A systematic review","volume":"9","author":"Schmalz","year":"2020","journal-title":"J Clin Med"}],"container-title":["Nigerian Journal of Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/njcp.njcp_166_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:55:07Z","timestamp":1786647307000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/njcp.njcp_166_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/njcp.njcp_166_25","relation":{},"ISSN":["1119-3077","2229-7731"],"issn-type":[{"value":"1119-3077","type":"print"},{"value":"2229-7731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-03-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}