{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:31:55Z","timestamp":1792812715046,"version":"4.5.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,6]]},"abstract":"\n Background:<\/jats:title>\n The burden of perinatal asphyxia remains high in our environment and when asphyxia is severe, vital organs are affected, with resultant multiorgan hypoxic-iscahemic injury to the heart, the brain, adrenals and other organs.<\/jats:p>\n <\/jats:sec>\n \n Study Aim:<\/jats:title>\n To evaluate for myocardial injury in asphyxiated term neonates with hypoxic ischaemic encephalopathy using serum cardiac troponin-I (cTnI).<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n The study was a hospital-based descriptive cross-sectional study involving sixty term asphyxiated neonates and sixty gestational age-and sex-matched controls. The subjects were term neonates with five-minute Apgar score \u2264 6 and HIE while the controls were healthy term neonates with five-minute Apgar score > 6. Five-minute Apgar score was utilized to classify asphyxia into mild, moderate and severe asphyxia. The degree of encephalopathy was determined by modified Sarnat and Sarnat criteria. The serum cTnI was measured in subjects and controls at 12-24 hours of life using Enzyme-linked immunosorbent assay technique. The serum bilirubin levels were also measured in participants to exclude hyperbilirubinemia.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The median serum cTnI levels was significantly higher in the subjects (0.56ng\/mL; 0.25-0.94ng\/mL) than in the controls (0.50ng\/mL; 0.00-0.67ng\/mL), respectively;\n p<\/jats:italic>\n =0.001. Similarly, the median serum cTnI level in HIE stage II (0.56ng\/mL; 0.38-0.72ng\/mL) or III (0.56ng\/ml; 0.50-0.94ng\/mL) was also significantly higher than the median value in HIE stage I (0.38ng\/mL;0.25-0.72ng\/mL) or in controls (0.50ng\/mL; 0.00-0.67ng\/mL);\n p<\/jats:italic>\n <0.001. There was significant positive correlation between serum cTnI levels and severity of HIE in asphyxiated neonates (rs = 0.505,\n p<\/jats:italic>\n < 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n serum cTnI levels were elevated in severely asphyxiated neonates with HIE. The concentration of serum cTnI demonstrated significant positive correlation with HIE severity. Hence, the presence of HIE in asphyxiated neonates should prompt an evaluation for myocardial injury using serum cTnI. Any derangement noted should warrant instituting cardiovascular support in order to improve outcome and reduce asphyxia-related mortality.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/njcp.njcp_169_24","type":"journal-article","created":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T03:00:49Z","timestamp":1719630049000},"page":"792-799","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of Myocardial Injury Using Serum Cardiac Troponin-I in Asphyxiated Neonates at Enugu State University Teaching Hospital, Enugu, South-East Nigeria"],"prefix":"10.4103","volume":"27","author":[{"given":"O","family":"Nwankwo","sequence":"first","affiliation":[{"name":"Department of Paediatrics, College of Medicine, Enugu State University Teaching Hospital (ESUTH), Park Lane, Enugu, Enugu State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DK","family":"Adiele","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, College of Medicine, University of Nigeria\/University of Nigeria Teaching Hospital (UNTH), Ituku Ozalla, Enugu State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Ekwochi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, College of Medicine, Enugu State University Teaching Hospital (ESUTH), Park Lane, Enugu, Enugu State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CA","family":"Idoko","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, College of Medicine, University of Nigeria\/University of Nigeria Teaching Hospital (UNTH), Ituku Ozalla, Enugu State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EK","family":"Obidike","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, College of Medicine, University of Nigeria\/University of Nigeria Teaching Hospital (UNTH), Ituku Ozalla, Enugu State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,29]]},"reference":[{"key":"R3-20260507","article-title":"Systemic effects of perinatal asphyxia","author":"Adcock","year":"2013","journal-title":"UpToDate 21_6 Updated"},{"key":"R4-20260507","first-page":"1","article-title":"Perinatal asphyxia in the term newborn","volume":"3","author":"Antonucci","year":"2014","journal-title":"J Pediatr Neonat Individual Med"},{"key":"R5-20260507","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1213\/00000539-195301000-00041","article-title":"A proposal for a new method of evaluation of the newborn 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