{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:05:05Z","timestamp":1787169905710,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"\n Background:<\/jats:title>\n Chronic limb-threatening ischemia (CLTI) is a complex disease caused by peripheral artery disease. It is associated with ischemic foot pain (rest pain) and tissue loss in the form of chronic nonhealing foot ulcers or gangrene. CLTI has a high short-term risk of limb amputations, postoperative sepsis, and cardiovascular-related events.<\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n The present study was conducted to assess the demographic and anthropometric profile of patients with CLTI and their postoperative outcomes after 2-year follow-up at Groote Schuur Hospital, Cape Town, South Africa.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n This prospective descriptive pilot study, nested in a prospective cohort study, included adult patients with CLTI admitted to Groote Schuur Hospital from 1\n st<\/jats:sup>\n January 2015 to 31\n st<\/jats:sup>\n December 2016. Demographic data, anthropometric markers of CLTI, and the postoperative outcomes were documented using piloted and pretested vascular questionnaire. Descriptive statistics were used for baseline data, and postoperative outcomes were presented using actuarial life-table method (Kaplan\u2013Meier analysis). Odds ratio, 95% confidence interval, and\n P<\/jats:italic>\n value < 0.05 were used to test the hypothesis.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Thirty-seven (50.6%) patients had a BMI >25.0. The mean waist: hip ratio was 0.96. Prevalence of smoking was 86%. Limb salvage and ambulation at 1 year were 79% and 67%, respectively. Majority of the patients who were ambulant preoperatively remained ambulant postoperatively.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Most patients had truncal obesity with a high prevalence of smoking. High postoperative ambulatory recovery among ambulant preoperative patients was a significant outcome observed in our study.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/njcp.njcp_190_20","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T03:28:40Z","timestamp":1692588520000},"page":"511-516","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Demographic, Clinical, and Anthropometric Profiles and Postoperative Outcomes in Patients with Chronic Limb Threatening Ischemia"],"prefix":"10.4103","volume":"24","author":[{"given":"Lily P.","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Paul","family":"Milambo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadraj","family":"Naidoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-9-20240907","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ejvs.2006.09.024","article-title":"Inter-society consensus for the management of peripheral arterial disease (TASC II)","volume":"33","author":"Norgren","year":"2007","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"R3-9-20240907","first-page":"S1","article-title":"Management of peripheral arterial disease (PAD)","volume":"31","author":"Dormandy","year":"2000","journal-title":"J Vasc Surg"},{"key":"R4-9-20240907","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1097\/01.SLA.0000071563.19208.50","article-title":"The LEGS score : A proposed grading system to direct treatment of chronic lower extremity ischemia","volume":"237","author":"Taylor","year":"2003","journal-title":"Ann Surg"},{"key":"R5-9-20240907","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1067\/mhj.2002.122871","article-title":"Prevalence and clinical correlates of peripheral arterial disease in the Framingham Offspring Study","volume":"143","author":"Murabito","year":"2002","journal-title":"Am Heart J"},{"key":"R7-9-20240907","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1532-5415.2007.01123.x","article-title":"Prevalence of peripheral arterial disease and risk factors in persons aged 60 and older: Data from the National Health and Nutrition Examination Survey 1999\u20132004","volume":"55","author":"Ostchega","year":"2007","journal-title":"J Am Geriatr Soc"},{"key":"R8-9-20240907","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1001\/jama.295.2.180","article-title":"REACH Registry Investigators: International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis","volume":"295","author":"Bhatt","year":"2006","journal-title":"JAMA"},{"key":"R9-9-20240907","first-page":"738","article-title":"Prevalence of and risk factors for peripheral arterial disease in the United States: Results from the national health and nutrition examination survey, 1999\u20132000 Elizabeth","volume":"110","author":"Selvin","year":"2004","journal-title":"Vasc Med"},{"key":"R10-9-20240907","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1358836X0100600i102","article-title":"Peripheral arterial disease \u2013 epidemiological aspects","volume":"6","author":"Criqui","year":"2001","journal-title":"Vasc Med"},{"key":"R11-9-20240907","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.jvs.2013.08.103","article-title":"Lower extremity arterial reconstruction for critical limb ischemia in diabetes","volume":"59","author":"Ballotta","year":"2014","journal-title":"J Vasc Surg"},{"key":"R12-9-20240907","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ejvs.2014.05.019","article-title":"Efficacy of revascularization for critical limb ischemia in patients with end-stage renal disease","volume":"48","author":"Yamamoto","year":"2014","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"R13-9-20240907","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jvs.2014.09.007","article-title":"Clinical outcome after infrapopliteal bypass surgery in chronic hemodialysis patients with critical limb ischemia","volume":"61","author":"Kumada","year":"2015","journal-title":"J Vasc Surg"},{"key":"R14-9-20240907","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0741-5214(98)70356-8","article-title":"Patient recovery after infrainguinal bypass grafting for limb salvage","volume":"27","author":"Nicoloff","year":"1998","journal-title":"J Vasc Surg"},{"key":"R15-9-20240907","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.jvs.2013.10.077","article-title":"Independence and mobility after infrainguinal lower limb bypass surgery for critical limb ischemia","volume":"59","author":"Ambler","year":"2014","journal-title":"J Vasc Surg"},{"key":"R16-9-20240907","doi-asserted-by":"crossref","first-page":"e105211","DOI":"10.1371\/journal.pone.0105211","article-title":"Peripheral Arterial Disease among adult diabetic patients attending a large outpatient diabetic clinic at a national referral hospital in Uganda : A descriptive cross sectional study","volume":"9","author":"Mwebaze","year":"2014","journal-title":"PLoS One"},{"key":"R17-9-20240907","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.jvs.2006.06.015","article-title":"Determinants of functional outcome after revascularization for critical limb ischemia: An analysis of 1000 consecutive vascular interventions","volume":"44","author":"Taylor","year":"2006","journal-title":"J Vasc Surg"},{"key":"R18-9-20240907","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0741-5214(97)70350-1","article-title":"Functional outcome after infrainguinal bypass for limb salvage","volume":"25","author":"Abou-Zamzam","year":"1997","journal-title":"J Vasc Surg"},{"key":"R19-9-20240907","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.jvs.2005.12.058","article-title":"Results of PREVENT III : A multicenter, randomized trial of edifoligide for the prevention of vein graft failure in lower extremity bypass surgery","volume":"43","author":"Conte","year":"2006","journal-title":"J Vasc Surg"},{"key":"R20-9-20240907","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1053\/ejvs.2002.1817","article-title":"A 1 year prospective study of management and outcome of patients presenting with critical lower limb ischaemia","volume":"25","author":"Bailey","year":"2003","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"R21-9-20240907","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jvs.2003.10.020","article-title":"A new look at outcomes after infrainguinal bypass surgery: Traditional reporting standards systematically underestimate the expenditure of effort required to attain limb salvage","volume":"39","author":"Goshima","year":"2004","journal-title":"J Vasc Surg"},{"key":"R22-9-20240907","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.jvs.2006.03.040","article-title":"Changing pattern of surgical revascularization for critical limb ischemia over 12 years: Endovascular vs open bypass surgery","volume":"44","author":"Kudo","year":"2006","journal-title":"J Vasc Surg"},{"key":"R23-9-20240907","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.ejvs.2015.12.006","article-title":"Anemia increases mortality after open or endovascular treatment in patients with critical limb ischemia: A retrospective analysis","volume":"51","author":"Velescu","year":"2016","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"R24-9-20240907","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0741-5214(86)90326-5","article-title":"Suggested standards for reports dealing with lower extremity ischemia","volume":"4","author":"Rutherford","year":"1986","journal-title":"J Vasc Surg"},{"key":"R25-9-20240907","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/BF02002137","article-title":"Outcome criteria in patients with peripheral arterial disease","volume":"7","author":"Strandness","year":"1993","journal-title":"Ann Vasc Surg"},{"key":"R26-9-20240907","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.jamcollsurg.2007.01.037","article-title":"Critical analysis of clinical success after surgical bypass for lower-extremity ischemic tissue loss using a standardized definition combining multiple parameters: A new paradigm of outcomes assessment","volume":"204","author":"Taylor","year":"2007","journal-title":"J Am Coll Surg"},{"key":"R27-9-20240907","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.jvs.2010.01.083","article-title":"Failure to achieve clinical improvement despite graft patency in patients undergoing infrainguinal lower extremity bypass for critical limb ischemia Jessica","volume":"51","author":"Simons","year":"2010","journal-title":"J Vasc Surg"},{"key":"R28-9-20240907","first-page":"95","article-title":"Chronic critical limb ischemia","volume":"109","author":"Dohmen","year":"2012","journal-title":"Dstch Arztebl Int"}],"container-title":["Nigerian Journal of Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/njcp.njcp_190_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:14:43Z","timestamp":1787166883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/njcp.njcp_190_20"}},"subtitle":["A Prospective Descriptive Study"],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/njcp.njcp_190_20","relation":{},"ISSN":["1119-3077"],"issn-type":[{"value":"1119-3077","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}