{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:05:00Z","timestamp":1787169900710,"version":"build-2736575974"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Aim:<\/jats:title>\n                    <jats:p>Prolonged jaundice is one of the most common problems during neonatal period. The aim of this study was to evaluate the efficiency of ursodeoxycholic acid (UDCA) treatment in newborn infants with prolonged unconjugated hyperbilirubinemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The present study included 27 patients who were fed by breast milk and followed up in the outpatient clinic due to prolonged jaundice without any underlying etiological factor; 10 mg\/kg\/day UDCA was administrated in two doses for 7 days. Furthermore, 20 newborns diagnosed with prolonged jaundice with same characteristics were enrolled as the control group. The control group was also given a placebo; demographic characteristics, liver functions tests before and after the treatment, bilirubin decrease rates, and hemogram parameters of groups were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Total bilirubin levels in the study and control groups before the treatment were 16.02 \u00b1 1.41 mg\/dL and 15.93 \u00b1 1.66 mg\/dL, respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.84). Total bilirubin levels in the study and control groups at day 7 after UDCA treatment were detected 8.18 \u00b1 2.31 mg\/dL and 13.92 \u00b1 2.66 mg\/dL, respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), and at day 14 after the treatment were 5.45 \u00b1 2.59 mg\/dL and 11.91 \u00b1 2.83 mg\/dL, respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Furthermore, serum aspartate aminotransferase (AST) was detected &lt;21 U\/L in the ROC analysis after UDCA treatment (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The study outcomes indicated that an efficient reduction in total bilirubin levels may be achieved, and outpatient clinic follow-up period may be reduced in patients whom UDCA was administrated. Moreover, it may be speculated that AST can be used to evaluate the efficacy after treatment. However, studies with larger sample sizes are needed for the routine use of UDCA in the treatment of prolonged jaundice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_216_22","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T04:28:17Z","timestamp":1695356897000},"page":"1226-1233","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["An Evaluation of Ursodeoxycholic Acid Treatment in Prolonged Unconjugated Hyperbilirubinemia due to Breast Milk"],"prefix":"10.4103","volume":"26","author":[{"given":"A","family":"Ozdemir","sequence":"first","affiliation":[{"name":"Department of Neonatalogy, University of Health Sciences, Kayseri City Hospital, Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Kurtoglu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Memorial Kayseri Hospital, Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Halis","sequence":"additional","affiliation":[{"name":"Department of Neonatalogy, Irmet Hospital, Tekirdag, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Bastug","sequence":"additional","affiliation":[{"name":"Department of Neonatalogy, University of Health Sciences, Kayseri City Hospital, Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"R1-20240907","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1053\/j.gastro.2014.03.047","article-title":"Inherited disorders of bilirubin transport and conjugation:New insights into molecular mechanisms and 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