{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:58:06Z","timestamp":1790618286062,"version":"4.1.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11]]},"abstract":"\n Background and Aim:<\/jats:title>\n \n Recent studies have demonstrated that hyoscine-\n n<\/jats:italic>\n -butylbromide has an antiemetic effect. We aimed to compare the effects of hyoscine-\n n<\/jats:italic>\n -butylbromide and ondansetron on postoperative nausea-vomiting (PONV) and pain after laparoscopic cholecystectomy.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n In this randomized study, a total of 134 patients between 18 and 65 years, who underwent laparoscopic cholecystectomy, were divided into two groups, and their demographic data were recorded. After routine monitoring, induction was performed with propofol, fentanyl, and rocuronium, then sevoflurane, and remifentanil were used for maintenance. After gallbladder removal, IV infusion of 1000 mg paracetamol and 1.5 mg\/kg tramadol was administered to the patients. Simultaneously, 20 mg hyoscine-\n n<\/jats:italic>\n -butylbromide (HBB) in 100 ml saline was administered in Group-HBB, and 4 mg ondansetron infusion in 100 ml saline was administered in Group-O. The patients were followed up in terms of nausea and vomiting, and pain at the postoperative 15\n th<\/jats:sup>\n and 30\n th<\/jats:sup>\n minutes and at the 3\n rd<\/jats:sup>\n , 6\n th<\/jats:sup>\n , 12\n th<\/jats:sup>\n , and 24\n th<\/jats:sup>\n h.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Total PONV rate was found to be 38%. In the 24-h follow-up of the patients, PONV was observed at least once in 26 (39.4%) patients in Group-HBB, and in 25 (36.7%) patients in Group-O, and there was no difference between the two groups. Scores of PONV, antiemetic use rates, VAS scores, and analgesic use rates were similar during the 24-h follow-up.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n The effects of hyoscine-\n n<\/jats:italic>\n -butylbromide and ondansetron on PONV and pain are similar in laparoscopic cholecystectomy. In laparoscopic cholecystectomies, hyoscine-\n n<\/jats:italic>\n -butylbromide is a good alternative for PONV prophylaxis in eligible patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/njcp.njcp_232_25","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T14:00:07Z","timestamp":1764424807000},"page":"1276-1281","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of the Effects of Hyoscine-N-Butylbromide and Ondansetron on Postoperative Nausea-Vomiting after Laparoscopic Cholecystectomy: A Prospective Randomized Study"],"prefix":"10.4103","volume":"28","author":[{"given":"S","family":"Abita\u011fao\u011flu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Reanimation, University of Health Sciences Fatih Sultan Mehmet Health Research and Application Center, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Erkan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, University of Health Sciences Fatih Sultan Mehmet Health Research and Application Center, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AC","family":"Bilgili","sequence":"additional","affiliation":[{"name":"Department of General Surgery, University of Health Sciences Fatih Sultan Mehmet Health Research and Application Center, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"\u00d6zkaya","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Medicine, Bursa Uludag University, 16059, Nilufer, Bursa, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130","family":"Ta\u015fdelen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, University of Health Sciences Fatih Sultan Mehmet Health Research and Application Center, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Erdo\u011fan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Ac\u0131badem Kozyata\u011f\u0131 Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4103\/aer.AER_192_18","article-title":"Postoperative nausea and vomiting prophylaxis: A comparative study of ramosetron and palonosetron in patients undergoing laparoscopic cholecystectomy-a prospective randomized trial","volume":"13","author":"Reddy","year":"2019","journal-title":"Anesth Essays Res"},{"key":"R2-20260420","first-page":"254","article-title":"The comparative study of ondansetron and metoclopramide effects in reducing nausea and vomiting after laparoscopic cholecystectomy","volume":"55","author":"Isazadehfar","year":"2017","journal-title":"Acta Med Iran"},{"key":"R3-20260420","doi-asserted-by":"crossref","first-page":"396","DOI":"10.4103\/aer.AER_19_18","article-title":"Minimum effective dose of dexamethasone in combination with midazolam as prophylaxis against postoperative nausea and vomiting after laparoscopic cholecystectomy","volume":"12","author":"Gupta","year":"2018","journal-title":"Anesth Essays Res"},{"key":"R4-20260420","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/s12871-024-02602-w","article-title":"Factors associated with postoperative nausea and vomiting after laparoscopic cholecystectomy at the National Referral Hospital, Bhutan: A cross-sectional study","volume":"24","author":"Jamtsho","year":"2024","journal-title":"BMC Anesthesiol"},{"key":"R5-20260420","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1080\/11101849.2023.2253074","article-title":"Hyoscine butyl-bromide versus ondansetron for nausea and vomiting during caesarean delivery under spinal anaesthesia. A randomized clinical trial","volume":"39","author":"Abbas","year":"2023","journal-title":"Egypt J Anaesth"},{"key":"R6-20260420","first-page":"482","article-title":"Effects of hyoscine-n-butylbromide on postoperative nausea and vomiting and postoperative pain in ureteroscopic procedures","volume":"9","author":"Abitagaoglu","year":"2020","journal-title":"Med Sci"},{"key":"R7-20260420","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/SLE.0b013e31827549e8","article-title":"Comparison of the efficacy of ondansetron and granisetron to prevent postoperative nausea and vomiting after laparoscopic cholecystectomy: A systematic review and meta-analysis","volume":"23","author":"Wu","year":"2013","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"key":"R8-20260420","first-page":"96","article-title":"The effects and comparative efficacy of dexamethasone and gabapentin on nausea and vomiting after laparoscopic cholecystectomy","volume":"32","author":"Avci","year":"2024","journal-title":"J Anestezi Derg (JARSS)"},{"key":"R9-20260420","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/cpdd.378","article-title":"Safety, tolerability, and pharmacokinetics of therapeutic and supratherapeutic doses of tramadol hydrochloride in healthy adults: A randomized, double-blind, placebo-controlled multiple-ascending-dose study","volume":"6","author":"DeLemos","year":"2017","journal-title":"Clin Pharmacol Drug Dev"},{"key":"R10-20260420","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.curtheres.2011.02.002","article-title":"Preventing postoperative nausea and vomiting after laparoscopic cholecystectomy: A prospective, randomized, double-blind study","volume":"72","author":"Arslan","year":"2011","journal-title":"Curr Ther Res Clin Exp"},{"key":"R11-20260420","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.rmu.2015.04.003","article-title":"Efficacy of antiemetic therapy in patients undergoing laparoscopic cholecystectomy","volume":"17","author":"Llanes-Garza","year":"2015","journal-title":"Medicina Universitaria"},{"key":"R13-20260420","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/aorn.12336","article-title":"Scopolamine use in the perioperative patient: A systematic review","volume":"108","author":"Kassel","year":"2018","journal-title":"AORN J"},{"key":"R14-20260420","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1213\/ANE.0000000000001617","article-title":"Combination of 5-HT3 antagonist and dexamethasone \u0131s superior to 5-HT3 antagonist alone for PONV prophylaxis after laparoscopic surgeries: A Meta-analysis","volume":"123","author":"Som","year":"2016","journal-title":"Anesth Analg"},{"key":"R15-20260420","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jclinane.2017.03.049","article-title":"The effect of ondansetron on analgesic efficacy of acetaminophen after hysterectomy: A randomized double blinded placebo controlled trial","volume":"40","author":"Koyuncu","year":"2017","journal-title":"J Clin Anesth"},{"key":"R16-20260420","first-page":"1553","article-title":"Ondansetron inhibits the analgesic effects of tramadol: A possible 5-HT (3) spinal receptor involvement in acute pain in humans","volume":"94","author":"Arcioni","year":"2002","journal-title":"Anesth Analg"},{"key":"R17-20260420","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000486747","article-title":"Hyoscine N-Butylbromide for preventing propofol \u0131njection pain: A Randomized, Placebo-Controlled and Double-Blind Study","volume":"27","author":"Sarg\u0131n","year":"2018","journal-title":"Med Princ Pract"},{"key":"R18-20260420","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1089\/bari.2019.0039","article-title":"Effect of Hyoscine-n-Butylbromide on multimodal analgesia for laparoscopic sleeve gastrectomy: A retrospective case-control study","volume":"15","author":"Kantekin","year":"2020","journal-title":"Bariatr Surg Pract Patient Care"}],"container-title":["Nigerian Journal of Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/njcp.njcp_232_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:48:41Z","timestamp":1787068121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/njcp.njcp_232_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/njcp.njcp_232_25","relation":{},"ISSN":["1119-3077","2229-7731"],"issn-type":[{"value":"1119-3077","type":"print"},{"value":"2229-7731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-04-15","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}