{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:03:53Z","timestamp":1787169833699,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Healthcare professionals working at COVID-19 pandemic clinics have to work with masks during long hours. After the widespread use of masks in the community, many mask-related side effects were reported to clinics. The increase in the number of applicants with dry eye symptoms due to mask use in ophthalmology clinics has led to the emergence of the concept of mask-associated dry eye (MADE). We think that it would be valuable to evaluate ocular surface tests with a comparative study using healthcare professionals working in pandemic clinics, which we think is the right study group to examine the effects of long-term mask use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>We aimed to evaluate the mask-associated dry eye (MADE) symptoms and findings in healthcare professionals who have to work prolonged time with face masks in coronavirus disease 2019 (COVID-19) pandemic clinics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>In this prospective, observational comparative clinical study, healthcare professionals who use the mask for a long time and work in COVID-19 pandemic clinics were compared with an age and sex-matched control group consisting of short-term masks users, from April 2021 to November 2021. All participants underwent the Ocular Surface Disease Index (OSDI) questionnaire, tear film break-up time (T-BUT), Oxford staining score, Schirmer\u2019s test I, and meibography with infrared transillumination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The long-term mask user group consisted of 64 people, while the short-term mask user group consisted of 66 people (260 eyes, total). The OSDI score and Schirmer I measurement were not statistically different between the two groups. T-BUT was statistically significantly shorter in the long-term group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      : 0.008); lid parallel-conjunctival fold, Oxford staining score, and upper and lower lid meibography score were found to be significantly higher in the long-term group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      : 0.004,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      : 0.049,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      : 0.044, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Healthcare professionals with longer mask-wearing times are at greater risk of ocular surface damage. It may be considered to prevent this damage by blocking airflow to the ocular surface, such as by wearing a face mask properly or fitting it over the nose with surgical tape. Those who have to work with a mask for a long time during the COVID-19 pandemic should keep in mind the ophthalmology follow-up for eye comfort and ocular surface health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_281_22","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T23:50:31Z","timestamp":1680911431000},"page":"319-323","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Mask-Associated Dry Eye (MADE) in Healthcare Professionals Working at COVID-19 Pandemic Clinics"],"prefix":"10.4103","volume":"26","author":[{"given":"E","family":"Celik","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Tekirdag Namik Kemal University, Tekirdag, Turkey"},{"name":"Department of Ophthalmology, Tekirdag Dr. \u0130. Fehmi Cumalioglu City Hospital, Tekirdag, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tekirdag Dr. \u0130. Fehmi Cumalioglu City Hospital, Tekirdag, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EK","family":"Gunder","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Tekirdag Namik Kemal University, Tekirdag, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Barut","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Tekirdag Namik Kemal University, Tekirdag, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Gonen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Tekirdag Namik Kemal University, Tekirdag, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,4,7]]},"reference":[{"key":"R1-20240907","doi-asserted-by":"crossref","first-page":"6655","DOI":"10.3390\/ijerph17186655","article-title":"Commentary:Physiological and psychological impact of face mask usage during the COVID-19 pandemic","volume":"17","author":"Scheid","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"R2-20240907","article-title":"Self-reported symptoms of mask-associated dry eye:A survey study of 3,605 people","volume":"101408","author":"Boccardo","year":"2021","journal-title":"Cont Lens Anterior Eye"},{"key":"R3-20240907","doi-asserted-by":"crossref","first-page":"130","DOI":"10.23937\/2474-3658\/1510130","article-title":"Adverse effects of prolonged mask use among healthcare professionals during COVID-19","volume":"6","author":"Elisheva","year":"2020","journal-title":"J Infect Dis Epidemiol"},{"key":"R4-20240907","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s40123-020-00282-6","article-title":"Face mask-associated ocular irritation and dryness","volume":"9","author":"Moshirfar","year":"2020","journal-title":"Ophthalmol Ther"},{"key":"R5-20240907","doi-asserted-by":"crossref","first-page":"448","DOI":"10.4103\/ijo.IJO_3250_20","article-title":"Mask-associated dry eye disease and dry eye due to prolonged screen time:Are we heading towards a new dry eye epidemic during the COVID-19 era?","volume":"69","author":"Pandey","year":"2021","journal-title":"Indian J Ophthalmol"},{"key":"R6-20240907","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1038\/s41433-020-01280-5","article-title":"Addressing post-operative Mask-Associated Dry Eye (MADE)","volume":"35","author":"Chadwick","year":"2021","journal-title":"Eye"},{"key":"R7-20240907","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1097\/ICO.0b013e31814923aa","article-title":"Reactivation of recurrent corneal erosion syndrome by continuous positive pressure ventilation","volume":"26","author":"Fayers","year":"2007","journal-title":"Cornea"},{"key":"R8-20240907","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.sleep.2016.08.026","article-title":"Bubbling test to recognize retrograde air escape via the nasolacrimal system during positive airway pressure therapy","volume":"29","author":"Bachour","year":"2017","journal-title":"Sleep Med"},{"key":"R9-20240907","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1177\/0003489414525924","article-title":"Retrograde air escape via the nasolacrimal system:A previously unrecognized complication of continuous positive airway pressure in the management of obstructive sleep apnea","volume":"123","author":"Singh","year":"2014","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"R10-20240907","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1542-0124(12)70081-2","article-title":"The definition and classification of dry eye disease:Report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007)","volume":"5","author":"Lemp","year":"2007","journal-title":"Ocul Surf"},{"key":"R11-20240907","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jcrc.2017.11.031","article-title":"Exposure keratopathy:Incidence, risk factors and impact of protocolised care on exposure keratopathy in critically ill adults","volume":"44","author":"Kousha","year":"2018","journal-title":"J Crit Care"},{"key":"R12-20240907","first-page":"947","article-title":"Coronavirus pandemic (COVID-19)","volume":"5","author":"Mathieu","year":"2020","journal-title":"Our World Data"},{"key":"R13-20240907","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1001\/archopht.118.5.615","article-title":"Reliability and validity of the ocular surface disease index","volume":"118","author":"Schiffman","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"R14-20240907","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.ophtha.2007.06.031","article-title":"Noncontact infrared meibography to document age-related changes of the meibomian glands in a normal population","volume":"115","author":"Arita","year":"2008","journal-title":"Ophthalmology"},{"key":"R15-20240907","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.clae.2012.10.074","article-title":"Comparison of subjective grading and objective assessment in meibography","volume":"36","author":"Pult","year":"2013","journal-title":"Cont Lens Anterior Eye"},{"key":"R16-20240907","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1167\/iovs.10-6997b","article-title":"The international workshop on meibomian gland dysfunction:Report of the definition and classification subcommittee","volume":"52","author":"Daniel Nelson","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R17-20240907","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.4103\/ijo.IJO_2465_20","article-title":"A review of meibography for a refractive surgeon","volume":"68","author":"Vunnava","year":"2020","journal-title":"Indian J Ophthalmol"},{"key":"R18-20240907","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12886-016-0292-3","article-title":"Prevalence of dry eye syndrome in residents of surgical specialties","volume":"16","author":"Castellanos-Gonz\u00e1lez","year":"2016","journal-title":"BMC Ophthalmol"}],"container-title":["Nigerian Journal of Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/njcp.njcp_281_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:13:51Z","timestamp":1787166831000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/njcp.njcp_281_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/njcp.njcp_281_22","relation":{},"ISSN":["1119-3077","2229-7731"],"issn-type":[{"value":"1119-3077","type":"print"},{"value":"2229-7731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"2022-04-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}