{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:56:56Z","timestamp":1790776616541,"version":"4.1.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>This retrospective investigation compared mandibular trabecular architecture on panoramic radiographs between hyperlipidemic adults who had used atorvastatin for at least 12 months and age- and sex-matched hyperlipidemic adults with no previous statin treatment. Trabecular complexity was assessed using fractal dimension (FD) analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings and Design:<\/jats:title>\n                    <jats:p>A total of 240 hyperlipidemic participants were included, comprising 120 individuals treated with atorvastatin for at least 1 year and 120 age- and sex-matched participants with no previous statin use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>FD measurements were obtained with ImageJ using the box-counting approach in four mandibular regions: the condyle, angulus, posterior mandible, and anterior mandible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis Used:<\/jats:title>\n                    <jats:p>\n                      Between-group and related comparisons were examined with the Mann\u2013Whitney U and Wilcoxon tests, and associations were assessed by Spearman correlation. The significance threshold was\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05, and the four predefined regional group comparisons were adjusted with the Bonferroni method.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mean FD values were numerically higher in the atorvastatin-treated group across all evaluated regions. However, after Bonferroni correction, only the difference in the mandibular angle remained statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.011; adjusted\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.044). A moderate positive correlation was identified between the mandibular angle and condyle (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.449,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Interobserver agreement was high (ICC range, 0.803\u20130.906).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although FD values tended to be higher among participants receiving atorvastatin therapy, statistical significance was confined to the mandibular angle, where the absolute difference was small. Therefore, long-term atorvastatin use may be associated with a subtle, site-specific radiographic variation in mandibular trabecular architecture among individuals with hyperlipidemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_340_26","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:00:37Z","timestamp":1790748037000},"page":"1018-1024","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Mandibular Trabecular Bone Microarchitecture in Statin-Treated Versus Statin-Naive Hyperlipidemic Patients"],"prefix":"10.4103","volume":"29","author":[{"given":"G","family":"Keldal","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Tokat Gaziosmanpa\u015fa University, Faculty of Dentistry, Tokat, 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