{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:34:31Z","timestamp":1787758471241,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9]]},"abstract":"\n \n Nodular vasculitis is a rare inflammatory disease of the skin and subcutaneous fat tissue, characterized by crops of small, tender, erythematous nodules on the legs, mostly on the calves and shins. We present a 17-year-old adolescent female who presented with a six-month history of cough; recurrent fever and bilateral lower limb multiple ulcerated nodules of 1-month duration. Clinical examination revealed generalized lymphadenopathy with bilateral pitting leg edema which had multiple nodules and discoid ulcers extending from the groin to the ankles and discharging purulent fluid. Tests for human immunodeficiency virus and tuberculosis were negative. Histology of nodule biopsy revealed extensive caseous and coagulative fat necrosis, granulomatous inflammation with epitheloid macrophages and multinucleated giant cells surrounding the necrosis, and lymphoid infiltration of vessel walls with fibrous thickening of the intima, typical of Whitfield-type erythema induratum. There was initial but very transient response to antibiotic treatment, with further deterioration and eventual death from overwhelming sepsis.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/njcp.njcp_348_22","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T13:57:08Z","timestamp":1663855028000},"page":"1611-1614","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Etiologic Dilemma and Challenges of Management of Nodular Vasculitis in Tertiary Health-Care Facility"],"prefix":"10.4103","volume":"25","author":[{"given":"JN","family":"Eze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CL","family":"Odimegwu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OC","family":"Okafor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IN","family":"Nwafia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-35-20240907","doi-asserted-by":"crossref","first-page":"383","DOI":"10.5021\/ad.2012.24.4.383","article-title":"Inflammatory nodules of the leg","volume":"24","author":"Cho","year":"2012","journal-title":"Ann Dermatol"},{"key":"R2-35-20240907","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jdds.2014.03.001","article-title":"Erythema Induratum of Bazin - Tuberculosis in disguise","volume":"19","author":"Babu","year":"2015","journal-title":"J Dermatol Dermatol Surg"},{"key":"R3-35-20240907","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/00000441-190112000-00016","article-title":"On the nature of the disease known as erthemainduratumscrofulosorum","volume":"122","author":"Whitfield","year":"1901","journal-title":"Am J Med Sci"},{"key":"R4-35-20240907","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1136\/adc.2005.080408","article-title":"Erythema induratum of Bazin and episcleritis in a 6 year old girl","volume":"90","author":"Leahy","year":"2005","journal-title":"Arch Dis Child"},{"key":"R5-35-20240907","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1440-0960.2008.00455.x","article-title":"Erythema induratum in a Kenyan child","volume":"49","author":"Thoo","year":"2008","journal-title":"Australas J Dermatol"},{"key":"R6-35-20240907","first-page":"38","article-title":"Erythema induratum caused by Mycobacterium chelonei in an immunocompetent patient","volume":"6","author":"Campbell","year":"2013","journal-title":"J Clin Aesthet Dermatol"},{"key":"R7-35-20240907","first-page":"160","article-title":"Erythema induratum- A type of cutaneous tuberculosis","volume":"57","author":"Nirmala","year":"2010","journal-title":"Indian J Tuberc"},{"key":"R8-35-20240907","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5070\/D30PP0Q5D2","article-title":"Erythema induratum of Bazin","volume":"16","author":"Sharon","year":"2010","journal-title":"Dermatol Online J"},{"key":"R9-35-20240907","first-page":"169","article-title":"Case of erythema induratum giving no evidence of tuberculosis","volume":"6","author":"Galloway","year":"1913","journal-title":"Proc R Soc Med"},{"key":"R10-35-20240907","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1001\/jama.1945.02860220017005","article-title":"Nodular vascular diseases of the legs: Erythema induratum and allied conditions","volume":"128","author":"Montgomery","year":"1945","journal-title":"J Am Med Assoc"},{"key":"R11-35-20240907","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0738-081X(99)00070-X","article-title":"Cutaneous vasculitis in Western Africa","volume":"17","author":"Amer","year":"1999","journal-title":"Clin Dermatol"}],"container-title":["Nigerian Journal of Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/njcp.njcp_348_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:15:44Z","timestamp":1787757344000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/njcp.njcp_348_22"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/njcp.njcp_348_22","relation":{},"ISSN":["1119-3077"],"issn-type":[{"value":"1119-3077","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]}}}