{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:22:36Z","timestamp":1787764956150,"version":"build-2784847793"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Testis sparing surgery (TSS) has an important role in preserving the functional capacity of testicular cancer (TC). Germ cell neoplasia\n                      <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                      (GCNIS) lesions in the remaining testis have a significant risk for local recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>We aimed to evaluate the presence of satellite GCNIS lesions around the primary tumor and to measure the distance of the furthest GCNIS lesion to the primary tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subject and Methods:<\/jats:title>\n                    <jats:p>The radical orchiectomy specimens of patients (n = 37) with a tumor size of \u22643 cm were reevaluated by the same pathologist. The satellite GCNIS lesions located around the primary tumor were detected, and the furthest GCNIS lesion distance to the primary tumor was measured under light microscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The mean tumor size was 1,9 \u00b1 0,6 cm. The mean furthest GCNIS distance to the primary tumor was 5,08 \u00b1 2,77 mm. A total of 19 (51,4%) patients had the furthest GCNIS lesions &lt;5 mm, and 28 (75,6%) patients had the furthest GCNIS lesions &lt;7 mm away from the primary lesion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Leaving a 5 mm safety margin during TSS would lead to excise the satellite GCNIS lesions in half of the patients. Increasing the safety margin to 7 mm would lead to excise the satellite GCNIS lesions at 75% of the patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_348_23","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T02:01:22Z","timestamp":1701655282000},"page":"1728-1733","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The Safe Surgical Margin for the Testis Sparing Surgery in Testicular Cancer"],"prefix":"10.4103","volume":"26","author":[{"given":"M","family":"Akg\u00fcl","sequence":"first","affiliation":[{"name":"Department of Urology, Faculty of Medicine, Tekirda\u011f Nam\u0131k Kemal University, Tekirda\u011f, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u0130","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Tekirda\u011f Nam\u0131k Kemal University, Tekirda\u011f, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CM","family":"Yaz\u0131c\u0131","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine, Tekirda\u011f Nam\u0131k Kemal University, Tekirda\u011f, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"R1-20240907","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.eururo.2013.11.004","article-title":"International variations and trends in testicular cancer incidence and mortality","volume":"65","author":"Znaor","year":"2014","journal-title":"Eur Urol"},{"key":"R2-20240907","doi-asserted-by":"crossref","first-page":"e12390","DOI":"10.1097\/MD.0000000000012390","article-title":"Recent global trends in testicular cancer incidence and mortality","volume":"97","author":"Park","year":"2018","journal-title":"Medicine"},{"key":"R3-20240907","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.eururo.2019.07.002","article-title":"International trends in the incidence of testicular cancer:Lessons from 35 years and 41 countries","volume":"76","author":"Gurney","year":"2019","journal-title":"Eur Urol"},{"key":"R4-20240907","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.urolonc.2020.02.023","article-title":"Testis-sparing surgery and scrotal violation for testicular masses suspicious for malignancy:A systematic review and meta-analysis","volume":"38","author":"Patel","year":"2020","journal-title":"Urol Oncol"},{"key":"R5-20240907","article-title":"H. 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