{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:46:39Z","timestamp":1792118799345,"version":"4.4.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The correlation between the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) with prognosis has been observed in different types of adult sarcomas. However, there is insufficient evidence in pediatric tumors. Our study aimed to examine if alterations in these characteristics serve as prognostic indicators in juvenile sarcomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A cohort group of 138 patients including Ewing sarcoma (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 62), osteosarcoma (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 52), and rhabdomyosarcoma (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 24), the most common pediatric sarcomas diagnosed and treated in our institute between January 2006 and December 2022, were retrospectively evaluated. Pre-treatment values of NLR, PLR, and LMR were calculated for all patients. These values were then evaluated about overall survival (OS) and disease-free survival (DFS), along with other established prognostic variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In terms of area under the ROC curve (AUC) values, NLR and LMR in osteosarcoma, NLR and PLR in Ewing sarcoma, and NLR in rhabdomyosarcoma were statistically significant. In patients with osteosarcoma (OS), NLR \u2265 3 and LMR &lt; 5.3 were found to be an independent prognostic factor for overall survival in multivariate analysis (HR, 2, 95% [CI], 1.1\u20138;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.049 and HR, 2.1, 95% [CI], 1.3\u20138.3;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.046, respectively). Furthermore, positive surgical margins were found to be an independent prognostic factor in OS patients (HR, 2.7, 95% CI, 1\u20139.2;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.045). In multivariate analysis, cut-off values of NLR \u2265 2.1 and PLR \u2265 194 were determined as prognostic factors for overall survival in patients with Ewing sarcoma (ES) (HR, 2.2, 95% [CI], 1\u20136.8;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.048, HR, 3.2, 95% [CI], 1.1\u20139;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.035, respectively). Metastatic disease was found to be correlated with poorer overall and disease-free survival rates in patients with ES. The hazard ratio for overall survival was 4 (95% confidence interval: 2.1\u201317.4;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03), while the hazard ratio for disease-free survival was 2.3 (95% confidence interval: 2\u20134.9;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.024). In the rhabdomyosarcoma (RMS) group, surgical margin positivity and NLR \u2265 4.6 were associated with worse overall survival rates in univariate analysis (HR, 4, 95% CI, 1.6\u201327.2;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.029 and HR, 2.2, 95% CI, 1.05\u20136.9;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.046, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study revealed that elevated NLR hurt OS and DFS in patients with osteosarcoma and Ewing sarcoma. Low LMR and high PLR were also associated with poor prognosis in these diseases, even in the presence of heterogeneity. In the rhabdomyosarcoma group, however, none of the markers provided a significant prognostic contribution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_377_24","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T01:00:09Z","timestamp":1741050009000},"page":"1448-1455","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic and Prognostic Role of Neutrophil\/Lymphocyte Ratio, Platelet\/Lymphocyte Ratio and Lymphocyte\/Monocyte Ratio in Pediatric Sarcomas"],"prefix":"10.4103","volume":"27","author":[{"given":"F","family":"Erdogan","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Traumatology, Amasya \u015eerefeddin Sabuncuo\u011flu State Hospital, Amasya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"\u00c7inka","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Acibadem Healthcare Group Bakirkoy Hospital, \u0130stanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Yurtbay","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Samsun University, Samsun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Sezgin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Amasya \u015eerefeddin Sabuncuo\u011flu State Hospital, Amasya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HS","family":"Coskun","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Dabak","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Ondokuz Mayis University Faculty of 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