{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T00:37:19Z","timestamp":1792975039852,"version":"4.5.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,2]]},"abstract":"\n Objective:<\/jats:title>\n The present study aimed to investigate the potential of neutrophil\/lymphocyte ratio (NLR), platelet\/lymphocyte ratio (PLR) and mean platelet volume (MPV) as prognostic markers in tinnitus patients at inflammatory process.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This study consisted of 216 subjects (124 males and 92 females), Routine laboratory CBC test results were calculated in this study. All the patients were divided into three groups according to their hearing thresholds: a high frequency hearing loss-tinnitus group (HFHL-TN) consisted of 55 subjects, an hearing loss in all frequencies tinnitus group (AFHL-TN) consisted of 53 subjects and a normal hearing-tinnitus group (NH-TN) consisted of 51 subjects. The control group (CNT) included 57 age-and sex-matched healthy subjects.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n NLR, PLR and MPV were observed in the HFHL-TN group when compared to AFHL-TN, NH-TN and CNT group (\n P<\/jats:italic>\n < 0.001). An increase in NLR was observed in the AFHL-TN group compared with the CNT group (\n P<\/jats:italic>\n = 0.004). The PLR value of the HFHL-TN group was significantly higher than that of the AFHL-TN (\n P<\/jats:italic>\n = 0.028) and NH-TN, CNT group (\n P<\/jats:italic>\n < 0001). The PLR value of the HFHL-TN group was significantly higher than that of the AFHL-TN (p=0.028) and NH-TN, CNT group (\n P<\/jats:italic>\n < 0001). MPV values in HFHL-TN group was slightly higher AFHL-TN group and significantly higher than NH-TN (\n P<\/jats:italic>\n = 0.025) and CNT (\n P<\/jats:italic>\n < 0.001) group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Our results confirm that elevated NLR, PLR and MPV values has been suggested to be a useful inflammatuar prognostic biomarker of tinnitus patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/njcp.njcp_381_19","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T02:55:50Z","timestamp":1692586550000},"page":"199-204","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Does Inflammation Play a Role in the Pathophysiology of Tinnitus?"],"prefix":"10.4103","volume":"24","author":[{"given":"M","family":"Demir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-9-20240907","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0168-0102(90)90031-9","article-title":"Phantom auditory perception (tinnitus):mechanisms of generation and perception","volume":"8","author":"Jastreboff","year":"1990","journal-title":"Neurosci Res"},{"key":"R2-9-20240907","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.tins.2004.08.010","article-title":"The neuroscience of tinnitus","volume":"27","author":"Eggermont","year":"2004","journal-title":"Trends Neurosci"},{"key":"R3-9-20240907","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0030-6665(02)00170-6","article-title":"Pathophysiology of tinnitus","volume":"36","author":"Moller","year":"2003","journal-title":"Otolaryngol Clin North Am"},{"key":"R4-9-20240907","doi-asserted-by":"crossref","first-page":"13452","DOI":"10.1523\/JNEUROSCI.2156-11.2011","article-title":"Tinnitus with a normal audiogram: Physiological evidence for hidden hearing loss and computational model","volume":"31","author":"Schaette","year":"2011","journal-title":"J Neurosci"},{"key":"R5-9-20240907","first-page":"73","article-title":"Alpha Rhythms inaudition: Cognitive and clinical perspectives","volume":"26","author":"Weisz","year":"2011","journal-title":"Front Psychol"},{"key":"R6-9-20240907","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1002\/lary.24551","article-title":"Neutrophil-to-lymphocyte ratio as a novel-potential marker for predicting prognosis of Bell palsy","volume":"124","author":"Bucak","year":"2014","journal-title":"Laryngoscope"},{"key":"R7-9-20240907","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/hdi.12040","article-title":"Platelet-to-lymphocyte ratio better predicts inflammation than neutrophil-to-lymphocyte ratio in end-stage renal disease patients","volume":"17","author":"Turkmen","year":"2013","journal-title":"Hemodial Int"},{"key":"R8-9-20240907","first-page":"152","article-title":"Mean platelet volume and splenomegaly as useful markers of subclinical activity in Egyptian children with familial mediterranean fever: A cross-sectional study","volume":"2015","author":"Marzouk","year":"2015","journal-title":"Int J Chronic Dis"},{"key":"R9-9-20240907","doi-asserted-by":"crossref","first-page":"e3000307","DOI":"10.1371\/journal.pbio.3000307","article-title":"Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models","volume":"17","author":"Wang","year":"2019","journal-title":"PLoS Biol"},{"key":"R10-9-20240907","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3109\/14397595.2015.1091136","article-title":"Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients","volume":"26","author":"Qin","year":"2016","journal-title":"Mod Rheumatol"},{"key":"R11-9-20240907","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0030-6665(02)00160-3","article-title":"Classification and epidemiology of tinnitus","volume":"36","author":"Heller","year":"2003","journal-title":"Otolarinygol Clin North Am"},{"key":"R12-9-20240907","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0163-8343(88)90037-0","article-title":"Disabling tinnitus. 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