{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:54Z","timestamp":1786650054025,"version":"build-2736575974"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"\n Background:<\/jats:title>\n Rifampicin, an antibiotic used in the treatment of tuberculosis has raised concerns about its potential liver and kidney toxicity.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n \n This study aimed to evaluate the protective effects of\n Aloe vera<\/jats:italic>\n against hepatorenal toxicity induced by rifampicin in male Wistar rats.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Thirty rats were divided into six groups (\n n<\/jats:italic>\n = 5): group A (control), group B treated with rifampicin, groups C\u2013E treated with varying doses (50, 100, and 200 mg\/kg) of\n Aloe vera<\/jats:italic>\n alongside rifampicin as well as a group F treated with furosemide and rifampicin for a total of 30 days. Alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), creatinine, urea, and histopathological changes were evaluated. One-way analysis of variance and Tukey\u2019s\n post hoc<\/jats:italic>\n tests were applied with a significance level of 5%.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Results showed 98.28%, 107.66%, and 334.66% increase in ALT, AST, and ALP levels of group B (Rifampicin only) compared with the control group. In contrast, groups treated with\n Aloe vera<\/jats:italic>\n showed significantly lower ALT, AST, and ALP levels as the dose increased from 50\u2013200 mg\/kg. A value of 2.23 Mg\/dL content as a lipid peroxidation marker was observed in group B in comparison to the control group indicating oxidative stress while animals treated with\n Aloe vera<\/jats:italic>\n at 50, 100, and 200 mg\/kg showed decreased levels of MDA (1.53, 1.13, and 0.80 Mg\/dL respectively) in comparison to group B. A decrease in CAT and SOD levels in the rifampicin-only treated animals was observed while there was an increase in CAT and SOD levels in animals treated with\n Aloe vera<\/jats:italic>\n and furosemide concomitantly with rifampicin. Creatinine and urea levels increased significantly in group B and reduced as\n Aloe vera<\/jats:italic>\n was introduced at 50, 100, and 200 mg\/kg respectively. Histopathological analysis confirmed liver and kidney tissue damage in rifampicin only and progressive regeneration in groups treated with\n Aloe vera<\/jats:italic>\n as the dose increased to 200 mg\/kg.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n The results of this study indicate that\n Aloe vera<\/jats:italic>\n has a protective effect against rifampicin-induced hepatorenal toxicity in a dose-dependent manner by mitigating oxidative stress and improving liver and kidney function markers.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/njcp.njcp_382_24","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T01:00:25Z","timestamp":1741050025000},"page":"1381-1390","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Concomitant Administration of Aloe Vera Gel and Rifampicin Protects Against Rifampicin Hepatorenal Toxicity in Male Wistar Rats"],"prefix":"10.4103","volume":"27","author":[{"given":"CM","family":"Adilieje","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Collage of Medicine, University of Nigeria, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CS","family":"Ejezie","sequence":"additional","affiliation":[{"name":"Department of Haematology and Immunology, University of Nigerian Teaching Hospital Ituku-Ozalla Enugu, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Obianyido","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Collage of Medicine, University of Nigeria, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ugwu","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Collage of Medicine, University of Nigeria, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OS","family":"Ezeadichie","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Collage of Medicine, University of Nigeria, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Ejezie","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Collage of Medicine, University of Nigeria, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"key":"R1-20260423","first-page":"206","article-title":"Protective effect of Moringara juice against CCl4 induced hepatotoxicity in animal model","volume":"43","author":"Abdel Azim","year":"2017","journal-title":"Food Sci 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