{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:19:06Z","timestamp":1787771946691,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Helicobacter pylori (H. pylori)<\/jats:italic>\n                      infections are widely treated with antibiotic regimens such as \u201cAmoxicillin 1 gr 2 \u00d7 1 tablet, Clarithromycin 500 mg 2 \u00d7 1 tablet, and Lansoprazole 30 mg 2 \u00d7 1 tablet\u201d for 14 days. We conducted a prospective observational study to explore whether this treatment protocol serves as a predisposing factor for the colonization of resistant gastrointestinal microflora, namely vancomycin-resistant enterococci (VRE), extended-spectrum beta-lactamase Enterobacterales (ESBL-E), and carbapenem-resistant Enterobacterales (CRE).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Pre- and post-treatment stool samples from 75 patients diagnosed with\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      , without a prior treatment history, were cultured and evaluated based on the European Committee on Antimicrobial Susceptibility Testing (EUCAST) criteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of the 75 evaluated patients, a pronounced surge in ESBL-E positivity was observed. Before initiating antibiotic treatment, 12 patients (16%) had ESBL-E-positive strains in their gastrointestinal tract. Notably, this number surged to 24 patients (32%) after the conclusion of the 14-day treatment regimen. The change was statistically significant, with a\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value of less than 0.002, indicating a clear association between treatment for\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      and heightened ESBL-E colonization. Notably, VRE and CRE remained undetected in patients throughout the study, suggesting that the treatment regimen may specifically amplify the risk of ESBL-E colonization without affecting VRE and CRE prevalence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      As the inaugural report from Turkey on this issue, our study suggests that antibiotic regimens for\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      eradication contribute to the increased risk of ESBL-positive bacterial colonization in the gastrointestinal tract.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_402_23","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T23:01:01Z","timestamp":1708988461000},"page":"289-295","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of Helicobacter Pylori \u0130nfection and the Colonization of the Gastrointestinal System by Resistant Bacteria"],"prefix":"10.4103","volume":"27","author":[{"given":"H","family":"Araz","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kocag\u00fcl-\u00c7elikba\u015f","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Hitit University, \u00c7orum, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Altunsoy","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130","family":"Mumcuo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University of Health Sciences, Gulhane Medical School Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Kazc\u0131","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Clinic, Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HT","family":"K\u00f6seo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Clinic, Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"R1-20240907","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1053\/j.gastro.2017.04.022","article-title":"Global prevalence of Helicobacter pylori infection:Systematic review and meta-analysis","volume":"153","author":"Hooi","year":"2017","journal-title":"Gastroenterology"},{"key":"R2-20240907","doi-asserted-by":"crossref","first-page":"e12597","DOI":"10.1111\/hel.12597","article-title":"Guidelines for the management of Helicobacter pylori infection in Japan:2016 revised edition","volume":"24","author":"Kato","year":"2019","journal-title":"Helicobacter"},{"key":"R3-20240907","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S1473-3099(19)30272-5","article-title":"Long-term changes of gut microbiota, antibiotic resistance, and metabolic parameters after Helicobacter pylori eradication:A multicentre, open-label, randomized trial","volume":"19","author":"Liou","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"R4-20240907","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1186\/1471-2458-13-1215","article-title":"Prevalence and risk factors of Helicobacter pylori in Turkey:A nationally-representative, cross-sectional, screening with the (1)(3) C-Ureabreath test","volume":"13","author":"Ozaydin","year":"2013","journal-title":"BMC Public Health"},{"key":"R5-20240907","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/cid\/ciu957","article-title":"Antimicrobials increase travelers'risk of colonization by extended-spectrum betalactamase-producing Enterobacteriaceae","volume":"60","author":"Kantele","year":"2015","journal-title":"Clin Infect Dis"},{"key":"R6-20240907","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1007\/s10096-015-2437-3","article-title":"Systematic analysis of the relationship between antibiotic use and extended-spectrum beta-lactamase resistance in Enterobacteriaceae in a French hospital:A time series analysis","volume":"34","author":"Vibet","year":"2015","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"R7-20240907","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1093\/jac\/dkv441","article-title":"Prevalence and risk factors for carriage of ESBL-producing Enterobacteriaceae in Amsterdam","volume":"71","author":"Reuland","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"R8-20240907","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/cid\/ciw743","article-title":"Proton pump inhibitor use is associated with extended-spectrum beta-lactamase-producing enterobacteriaceae rectal carriage at hospital admission:A cross-sectional study","volume":"64","author":"Huizinga","year":"2017","journal-title":"Clin Infect Dis"},{"key":"R9-20240907","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jhin.2018.05.023","article-title":"Proton pump inhibitor use as a risk factor for Enterobacteriaceal infection:A case-control study","volume":"100","author":"Cunningham","year":"2018","journal-title":"J Hosp Infect"},{"key":"R10-20240907","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13756-018-0427-9","article-title":"Intestinal colonization due to Escherichia coli ST131:Risk factors and prevalence","volume":"7","author":"Morales Barroso","year":"2018","journal-title":"Antimicrob Resist Infect Control"},{"key":"R11-20240907","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.cmi.2017.03.026","article-title":"Risk factors for extended-spectrum beta-lactamase-producing Escherichia coli urinary tract infection in the community in Denmark:A case-control study","volume":"23","author":"Sogaard","year":"2017","journal-title":"Clin Microbiol Infect"},{"key":"R12-20240907","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-2125.2011.04161.x","article-title":"The impact of antibiotic use on the incidence and resistance pattern of extended-spectrum beta-lactamase-producing bacteria in primary and secondary healthcare settings","volume":"74","author":"Aldeyab","year":"2012","journal-title":"Br J Clin Pharmacol"},{"key":"R13-20240907","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13756-018-0387-0","article-title":"Intra-hospital differences in antibiotic use correlate with antimicrobial resistance rate in Escherichia coli and Klebsiella pneumoniae:A retrospective observational study","volume":"7","author":"Cusini","year":"2018","journal-title":"Antimicrob Resist Infect Control"},{"key":"R14-20240907","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1080\/21505594.2019.1596507","article-title":"Ciprofloxacin, amoxicillin, and aminoglycosides stimulate genetic and phenotypic changes in uropathogenic Escherichia coli strains","volume":"10","author":"Adamus-Bialek","year":"2019","journal-title":"Virulence"},{"key":"R15-20240907","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ajic.2015.12.005","article-title":"Risk of infection following colonization with carbapenem-resistant Enterobactericeae:A systematic review","volume":"44","author":"Tischendorf","year":"2016","journal-title":"Am J Infect Control"},{"key":"R16-20240907","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.jiac.2018.03.009","article-title":"Risk factors for fecal carriage of IMP-6-producing Enterobacteriaceae at a long-term care hospital in Japan:A follow-up report from the northern Osaka multicentre study group","volume":"24","author":"Hagiya","year":"2018","journal-title":"J Infect Chemother"},{"key":"R17-20240907","first-page":"546","article-title":"Comparison of ertapenem-EMB Agar with traditional methods for screening carbapenem-resistant Klebsiella pneumoniae from rectal swabs","volume":"46","author":"Per\u00e7in","year":"2012","journal-title":"Mikrobiyol Bul"},{"key":"R18-20240907","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/njcp.njcp_79_17","article-title":"Fecal carriage of extended-spectrum beta-lactamase and ampc beta-lactamase-producing Enterobacteriaceae in a Turkish community","volume":"21","author":"Hazirolan","year":"2018","journal-title":"Niger J Clin Pract"},{"key":"R19-20240907","first-page":"36","article-title":"Resistant enterococci:A prospective study of prevalence, incidence, and factors associated with colonization in a university hospital","volume":"17","author":"Weinstein","year":"1996","journal-title":"Infect Control Hosp Epidemiol"},{"key":"R20-20240907","first-page":"87","article-title":"Isolation of vancomycin resistant enterococci from animal faeces, detection of antimicrobial resistance profiles and vancomycin resistant genes","volume":"21","author":"Ba\u011fc\u0131gil","year":"2015","journal-title":"Kafkas Univ Vet Fak Derg"},{"key":"R21-20240907","first-page":"235","article-title":"Phenotypic and genotypic analysis of antibiotic resistance of chicken and seagull enterococci","volume":"63","author":"Akg\u00fcl","year":"2016","journal-title":"Ankara Univ Vet Fak Derg"},{"key":"R22-20240907","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0732-8893(98)00052-2","article-title":"Colonization and microbiology of the motile enterococci in a patient population","volume":"31","author":"Van Horn","year":"1998","journal-title":"Diagn Microbiol Infect Dis"},{"key":"R23-20240907","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0732-8893(03)00033-6","article-title":"Detection of intrinsic vancomycin resistant enterococci in animal and human feces","volume":"46","author":"Rice","year":"2003","journal-title":"Diagn Microbiol Infect Dis"},{"key":"R24-20240907","first-page":"83","article-title":"In vitro antimicrobial activity against enterococci isolated in a university hospital in Sao Paulo, Brazil","volume":"1","author":"Cereda","year":"1997","journal-title":"Braz J Infect Dis"},{"key":"R25-20240907","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1590\/S0074-02762004000700018","article-title":"Antimicrobial resistance of Enterococcus sp. isolated from the intestinal tract of patients from a university hospital in Brazil","volume":"99","author":"Maschieto","year":"2004","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"R26-20240907","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1128\/JCM.42.2.855-857.2004","article-title":"Prevalence of vancomycin-resistant enterococcus in prenatal screening cultures","volume":"42","author":"Miller","year":"2004","journal-title":"J Clin Microbiol"},{"key":"R27-20240907","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1128\/jcm.35.12.3166-3170.1997","article-title":"Clinical and epidemiological significance of enterococci intrinsically resistant to vancomycin (possessing the vanC genotype)","volume":"35","author":"Toye","year":"1997","journal-title":"J Clin Microbiol"},{"key":"R28-20240907","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jiac.2017.03.009","article-title":"A 10-year profile of enterococcal bloodstream infections at a tertiary-care hospital in Japan","volume":"23","author":"Suzuki","year":"2017","journal-title":"J Infect Chemother"}],"container-title":["Nigerian Journal of Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/njcp.njcp_402_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:22:19Z","timestamp":1787768539000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/njcp.njcp_402_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/njcp.njcp_402_23","relation":{},"ISSN":["1119-3077","2229-7731"],"issn-type":[{"value":"1119-3077","type":"print"},{"value":"2229-7731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"2023-05-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-21","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}