{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:42Z","timestamp":1786650042517,"version":"build-2736575974"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Heart failure during pregnancy is rare, potentially serious, and complicates approximately 1% of all pregnancies. However, there is a global dearth of data on heart failure in pregnancy, and no data from southeastern Nigeria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To determine the prevalence, clinical profile, and outcomes of pregnancy in women presenting with heart failure during pregnancy at the University of Nigeria, Enugu.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A hospital-based, retrospective study covering 9 years between 2013 and 2021, using data from the medical records of patients seen at the cardiology and obstetrics\/gynecology units. Information on the clinical profile, echocardiographic reports, and pregnancy outcomes were obtained and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 9749 new pregnant women, 26 (0.3%) had heart failure during pregnancy, with a prevalence rate of 0.3% and a mean age of 33.27 years. Among 26 women, peripartum cardiomyopathy (46%) was the most common cause of heart failure. The most common presenting symptoms were breathlessness (84.62%), bilateral leg swelling (69.24%), and paroxysmal nocturnal dyspnoea (65.39%). The majority presented with New York Heart Association classes III (57.7%) and IV (26.9%). The most affected age group and mode of delivery were 31\u201340 years (82%) and cesarean section (50%), respectively. Pregnancy outcomes showed high maternal (11.5%) and fetal\/neonatal (15.4%) mortality rates. There was a significant association between the etiology and severity of heart failure (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.009), and the trimester of pregnancy at presentation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>heart failure in pregnancy is associated with high maternal and fetal mortality. The most common cause of heart failure in South Eastern Nigeria was peripartum cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_415_24","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T08:00:07Z","timestamp":1744358407000},"page":"344-351","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Synopsis and Pregnancy Outcome of Decompensated Heart Failure in Pregnancy at a Tertiary Health Care Centre in South-Eastern Nigeria: A Retrospective Study"],"prefix":"10.4103","volume":"28","author":[{"given":"NC","family":"Mbadiwe","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Nigeria Teaching Hospital, Ituku\/Ozalla, Enugu, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JU","family":"Onyebueze","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Nigeria Teaching Hospital, Ituku\/Ozalla, Enugu, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AV","family":"Ikemeh","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Nigeria Teaching Hospital, Ituku\/Ozalla, Enugu, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EO","family":"Izuka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University of Nigeria Teaching Hospital, Ituku\/Ozalla, Enugu, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OM","family":"Mbadiwe","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Nigeria Teaching Hospital, Ituku\/Ozalla, Enugu, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BA","family":"Ezeala-Adikaibe","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Nigeria Teaching Hospital, Ituku\/Ozalla, Enugu, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CI","family":"Ikaraoha","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, Imo State University, Owerri, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SO","family":"Ike","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Nigeria Teaching Hospital, Ituku\/Ozalla, Enugu, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BJ","family":"Onwubere","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Nigeria Teaching Hospital, Ituku\/Ozalla, Enugu, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"R1-20260423","first-page":"2179","article-title":"Adverse neonatal and cardiac outcomes are more common in pregnant women with cardiac 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