{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:35:56Z","timestamp":1786649756727,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Systemic inflammation indices derived from complete blood count parameters have recently gained attention as potential biomarkers in autoimmune diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>This study aimed to investigate the relationship between minor salivary gland biopsy results with the pan-immune-inflammation value (PIV) and systemic inflammation response index (SIRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>File records of patients who underwent minor salivary gland biopsy at the Otorhinolaryngology Department between December 01, 2020 and May 01, 2023 were reviewed. In Group 1, the lymphocytic infiltration focus score was \u22641, whereas in Group 2, it was &gt;1. Group 1 and Group 2 were statistically compared in terms of age, sex, complete blood test parameters, PIV, and SIRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Data from 200 patients were included in the study. There were 71 patients (35.5%) in Group 1 and 129 patients (64.5%) in Group 2. No significant differences were found between the groups in terms of white blood cell count, neutrophil count, lymphocyte count, monocyte count, platelet count, and PIV values (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      -values: 0.248, 0.148, 0.232, 0.061, 0.071, and 0.056, respectively). A significant difference was observed only for the SIRI value, which was lower in Group 2 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.012).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our findings support the possibility that there may not be a parallel relationship between local glandular inflammation and systemic immune response. Systemic inflammation indices such as SIRI and PIV should be interpreted with caution in the context of disease phenotype, pattern of tissue involvement, and immune cell distribution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_415_25","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:00:20Z","timestamp":1774926020000},"page":"262-265","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of the Relationship Between Minor Salivary Gland Biopsy Findings and Pan-Immune-Inflammation Value (PIV) and Systemic Inflammation Response Index (SIRI)"],"prefix":"10.4103","volume":"29","author":[{"given":"B","family":"B\u00fcy\u00fck\u00e7elik","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Isparta City Hospital, Isparta, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Yasan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine, S\u00fcleyman Demirel University, Isparta, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Ak\u0131n","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine, S\u00fcleyman Demirel University, Isparta, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ME","family":"Sivrice","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine, S\u00fcleyman Demirel University, Isparta, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"T\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine, S\u00fcleyman Demirel University, Isparta, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Keskin","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine, S\u00fcleyman Demirel University, Isparta, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"R1-20260416","doi-asserted-by":"crossref","first-page":"5928232","DOI":"10.1155\/2021\/5928232","article-title":"Advances in Pathogenesis of Sj\u00f6gren\u2019s Syndrome","volume":"2021","author":"Tian","year":"2021","journal-title":"J Immunol Res"},{"key":"R2-20260416","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.3390\/jcm9072299","article-title":"Current state of Knowledge on Primary Sj\u00f6gren\u2019s Syndrome, an autoimmune exocrinopathy","volume":"9","author":"Parisis","year":"2020","journal-title":"J Clin Med"},{"key":"R3-20260416","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4103\/njcp.njcp_246_24","article-title":"Examination of pan-immune-inflammation value and lymphocyte-monocyte ratio in sudden sensorineural hearing loss","volume":"28","author":"Akin","year":"2025","journal-title":"Niger J Clin Pract"},{"key":"R4-20260416","doi-asserted-by":"crossref","first-page":"29","DOI":"10.26650\/Tr-ENT.2025.1466632","article-title":"Evaluation of the pan-immune-inflammation value in patients with chronic rinosinusitis","volume":"35","author":"Sivrice","year":"2025","journal-title":"Tr-ENT"},{"key":"R5-20260416","first-page":"225","article-title":"A new biomarker in Sjogren\u2019s Syndrome? 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