{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:57:10Z","timestamp":1790776630439,"version":"4.1.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"\n Background:<\/jats:title>\n Systemic inflammation and impaired nutritional status are important drivers of adverse outcomes in peripheral artery disease (PAD). The hemoglobin\u2013albumin\u2013lymphocyte\u2013platelet index (HALP) represents a multidimensional marker reflecting the interaction between hematologic, nutritional, and inflammatory status.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n This study evaluated the independent prognostic value of HALP score and neutrophil-lymphocyte ratio (NLR) in determining mortality in PAD patients.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This retrospective cohort study consisted of 638 individuals with a first-time diagnosis of PAD. Patients were categorized as deceased (n = 241) and survivors (n = 397). Clinical characteristics, laboratory findings, inflammatory indices, NLR and HALP scores were analyzed. Survival probabilities were assessed using Kaplan\u2013Meier curves, and independent determinants of mortality were examined through logistic regression analysis.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The mean follow-up period was 36.17 months for deceased patients and 71.69 months for survivors. Deceased patients exhibited significantly lower HALP scores (34.6 \u00b1 2.1 vs. 51.9 \u00b1 2.2,\n P<\/jats:italic>\n = 0.047). While the HALP score demonstrated weak discriminative capacity in ROC analysis, Cox regression showed that lower HALP levels were independently associated with decreased survival status (Hazard ratio (HR) 0.46; 95% confidence interval (CI): 0.35\u20130.60;\n P<\/jats:italic>\n < 0.001). The higher NLR levels had significantly elevated all-cause mortality rates (HR, 1.87; 95% CI: 1.44\u20132.44;\n P<\/jats:italic>\n < 0.001). In multivariable analysis, HALP score, age, C-reactive protein levels, chronic renal failure, diabetes mellitus, and heart failure were independent predictors of death.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Lower HALP scores are related to increased long-term mortality in PAD. The HALP score provides complementary prognostic information and may enhance holistic risk stratification in PAD.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/njcp.njcp_44_26","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:00:44Z","timestamp":1790748044000},"page":"1049-1056","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Impact of the Neutrophil-to-Lymphocyte Ratio and HALP Score on Long-Term Mortality in Patients with Peripheral Artery Disease: A Retrospective Cohort Study in a Tertiary Hospital in Turkey"],"prefix":"10.4103","volume":"29","author":[{"given":"Z","family":"Yal\u0131m","sequence":"first","affiliation":[{"name":"Department of Cardiology, Afyonkarahisar Health Science University, Afyonkarahisar, 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