{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:32:25Z","timestamp":1786649545477,"version":"build-2736575974"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acute kidney injury (AKI) is a frequent complication of congenital heart surgery with cardiopulmonary bypass (CPB) in pediatric patients, contributing to significant morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To determine the prevalence and perioperative predictors of AKI after pediatric CPB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this single-center retrospective cohort study, medical records of 84 pediatric patients (&lt;18 years) undergoing elective or urgent CPB-assisted congenital heart surgery (November 2018\u2013December 2024) were reviewed. AKI was diagnosed using kidney disease: Improving Global Outcomes (KDIGO) criteria. Demographic, clinical, and laboratory variables were analyzed via univariate and multivariate logistic regression; predictive accuracy was assessed with receiver operating characteristic (ROC) analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      AKI occurred in 32.1% of patients, predominantly KDIGO stage 1. Independent predictors included lower preoperative creatinine (OR\n                      <jats:bold>=<\/jats:bold>\n                      0.019\n                      <jats:bold>,<\/jats:bold>\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      <jats:bold>=<\/jats:bold>\n                      0.040), lower body weight (OR = 0.92,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      <jats:bold>=<\/jats:bold>\n                      0.024), and higher postoperative day 1 blood urea nitrogen (BUN) (OR = 1.05\n                      <jats:bold>,<\/jats:bold>\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      <jats:bold>=<\/jats:bold>\n                      0.007). Preoperative creatinine (AUC = 0.82) and postoperative day 1 BUN (AUC = 0.73) had the highest discriminative ability. AKI was associated with prolonged intubation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.017), higher vasoactive-inotropic scores on postoperative days 1\u20133, and increased peritoneal dialysis rates (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.032).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Lower baseline creatinine and body weight, along with elevated early postoperative BUN, independently predict AKI after pediatric CPB. Incorporating these parameters into perioperative risk models may facilitate early renal-protective strategies. Prospective studies with larger cohorts and biomarker integration are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_462_25","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T13:00:09Z","timestamp":1767013209000},"page":"1404-1412","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Early Predictors of Acute Kidney Injury After Pediatric Cardiopulmonary Bypass: A Retrospective Cohort Analysis"],"prefix":"10.4103","volume":"28","author":[{"given":"H","family":"\u0130\u015ftar","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, and Medical Faculty, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University, Mu\u011fla, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Harmandar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, and Medical Faculty, 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