{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:03:26Z","timestamp":1787169806164,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>This study aimed to compare the effect of spinal anesthesia on QT interval in severe pre-eclamptic and normotensive parturients who underwent cesarean section in a Nigerian tertiary hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>Twelve-lead electrocardiogram (ECG) was obtained before, and at intervals after spinal anaesthesia on fifty severe pre-eclamptic (Group A) and fifty normotensive parturients (Group B) who underwent caesarean section. The effect of spinal anaesthesia on QT interval was compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The preoperative (baseline) mean QT interval was longer in group A than in group B; 453.10 \u00b1 34.11 ms versus 399 \u00b1 18.79 ms,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001. The prevalence of prolonged QT interval in the severe pre-eclamptic group before spinal anesthesia was 80% while in the normotensive group it was 0%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001. At 5, 30, 60, and 120 min after the establishment of spinal anesthesia, the mean QT interval in the severe pre-eclamptic group was shortened and maintained within normal limits; 414.74 \u00b1 28.05, 418.28 \u00b1 30.95, 411.18 \u00b1 19.21 and 401.36 \u00b1 17.52 ms with\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001 throughout. In the normotensive group, there was no significant change in the mean QT interval.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study demonstrated that the QT interval was more prolonged among the severe pre-eclamptic parturients. Spinal anesthesia using 0.5% hyperbaric bupivacaine normalized the QT interval and maintained it within normal limits during the study period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_495_20","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T06:45:10Z","timestamp":1650350710000},"page":"401-405","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Spinal Anesthesia on QT 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