{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:05:00Z","timestamp":1787169900804,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Our aim was to compare the efficacy of two triggering method one with dual triggering with gonadotropin-realising hormon (GnRH) agonist plus standard dosage human chorionic gonadotropin (hCG) and the other with hCG only for final oocyte maturation on oocyte\/follicle ratio and pregnancy rates in normoresponders in GnRH antagonist cycles in invitro fertilization-intrastoplasmic sperm injection (IVF-ICSI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material Methods:<\/jats:title>\n                    <jats:p>In this retrospective study, all patients underwent GnRH antagonist protocol. When at least \u22653 follicles reached \u226517 mm diameter, 116 patients received dual trigger with GnRH agonist plus hCG (1mg Leuprolide acetate plus 10.000 IU uhCG) and 178 patients received uhCG (10.000 IU u hCG) for final oocyte maturation. All follicles \u226510 mm diameter were aspirated. Number of oocytes and metaphase II oocytes retrieved per aspirated follicles, implantation rate, and clinical pregnancy rate per cycle was recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There was no statistically significant difference in terms of metaphase II oocyte ratio per aspirated follicle, implantation rate and clinical pregnancy rate between the dual trigger group and hCG only group (45.7% vs. 51%; 35.4% vs.30.3% and 45%vs. 40% respectively). Oocyte\/ follicle ratio was significantly higher in dual trigger group (68.2%vs 63.8% p=0,028).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Dual triggering in normal responders with a GnRH-agonist and a standard dosage of hCG is superior to hCG only protocol in terms of oocyte\/follicle ratio but does not improve metaphase II oocyte, implantation and clinical pregnancy rates in GnRH-antagonist cycles. Dual triggering method may be beneficial in patients with immature oocytes and emty follicle syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_574_19","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:57:26Z","timestamp":1692579446000},"page":"1159-1163","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of Dual Trigger with Combination of Gonadotropin-Releasing Hormone Agonist and Human Chorionic Gonadotropin in \u0130mproving Oocyte-Follicle Ratio in Normo-Responder Patients"],"prefix":"10.4103","volume":"24","author":[{"given":"AS","family":"Gurbuz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Deveer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Gode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20240907","first-page":"CD001750","article-title":"Gonadotrophin releasing hormone antagonists for assisted reproductive technology","volume":"5","author":"Al-Inany","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"R2-8-20240907","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/humrep\/deh613","article-title":"Can we eliminate severe ovarian hyperstimulation syndrome?","volume":"20","author":"Orvieto","year":"2005","journal-title":"Hum Reprod"},{"key":"R3-8-20240907","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1093\/humrep\/der251","article-title":"An OHSS-Free clinic by segmentation of IVF treatment","volume":"6","author":"Devroey","year":"2011","journal-title":"Hum Reprod"},{"key":"R4-8-20240907","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1093\/humrep\/dei150","article-title":"A lower ongoing pregnancy rate can be expected when GnRH agonist is used for triggering final oocyte maturation instead of hCG in patients undergoing IVF with GnRH antagonists","volume":"20","author":"Kolibianakis","year":"2005","journal-title":"Hum Reprod"},{"key":"R5-8-20240907","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1093\/humrep\/deh765","article-title":"GnRH agonist (buserelin) or hCG for ovulation induction in GnRH antagonist IVF\/ICSI cycles: A prospective randomized study","volume":"20","author":"Humaidan","year":"2005","journal-title":"Hum Reprod"},{"key":"R6-8-20240907","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1472-6483(10)60612-8","article-title":"Rescue of corpus luteum function with peri-ovulatory HCG supplementation in IVF\/ICSI GnRH antagonist cycles in which ovulation was triggered with a GnRH agonist: A pilot study","volume":"13","author":"Humaidan","year":"2006","journal-title":"Reprod Biomed Online"},{"key":"R7-8-20240907","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.fertnstert.2008.12.042","article-title":"1,500 IU human chorionic gonadotropin administered at oocyte retrieval rescues the luteal phase when gonadotropin- releasing hormone agonist is used for ovulation induction: A prospective, randomized, controlled study","volume":"93","author":"Humaidan","year":"2010","journal-title":"Fertil Steril"},{"key":"R8-8-20240907","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.fertnstert.2007.07.1312","article-title":"Empty follicle syndrome: The reality of a controversial syndrome, a systematic review","volume":"90","author":"Stevenson","year":"2008","journal-title":"Fertil Steril"},{"key":"R9-8-20240907","doi-asserted-by":"crossref","first-page":"132","DOI":"10.5653\/cerm.2012.39.4.132","article-title":"Empty follicle syndrome","volume":"39","author":"Kim","year":"2012","journal-title":"Clin Exp Reprod Med"},{"key":"R10-8-20240907","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.fertnstert.2007.07.1316","article-title":"Can pregnancy rate be improved in gonadotropin-releasing hormone (GnRH) antagonist cycles by administering GnRH agonist before oocyte retrieval? 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