{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:18:12Z","timestamp":1787840292117,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"\n Background:<\/jats:title>\n Cervical pathologies, from chronic cervicitis to cervical cancer, are a global public health issue. Inflammation is crucial to these disorders\u2019 development. The systemic inflammatory response may predict cancer and chronic inflammatory disease outcomes.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n This study aimed to determine the importance of systemic inflammatory response indicators in human papillomavirus (HPV) infection and cervical pathologies.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n In this retrospective analysis, pap smear, HPV, cervical biopsy, complete blood count (CBC) parameters, and systemic inflammatory response index (SIRI) of women who underwent gynecological examination were evaluated.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The study included 452 women. Mean platelet volume (MPV) was comparable in HPV other high-risk positive and negative women but lower in HPV Type-16\/18 positive women (\n P<\/jats:italic>\n < 0.001). Neutrophil\/lymphocyte ratio, lymphocyte\/monocyte ratio, eosinophil\/lymphocyte ratio (ELR), platelet\/lymphocyte ratio (PLR), systemic inflammatory index [SII (platelet \u00d7 neutrophil\/lymphocyte)], and SIRI (neutrophil \u00d7 monocyte\/lymphocyte) were also similar (\n P<\/jats:italic>\n > 0.05). Low-grade intraepithelial lesion (LSIL) women have lower ages and pregnancies at pap smear (\n P<\/jats:italic>\n < 0.05). The high-grade intraepithelial lesion (HSIL) group showed greater platelet (PLT) counts and decreased MPV than the other groups (\n P<\/jats:italic>\n < 0.05). The LSIL group had considerably reduced eosinophil counts (\n P<\/jats:italic>\n < 0.05). ELR was lower in the LSIL group (\n P<\/jats:italic>\n = 0.004). PLR was the highest for HSIL and lowest for LSIL (\n P<\/jats:italic>\n = 0.002). The SII was highest in the HSIL group and lowest in the LSIL group (\n P<\/jats:italic>\n = 0.008). PLT and MPV were lower in the cervical biopsy-classified women than in the other cervical pathology and control groups (\n P<\/jats:italic>\n = 0.03 and 0.001, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n We found a link between the mean PLT volume and HPV-related cervical disease.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/njcp.njcp_581_24","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T01:01:19Z","timestamp":1748998879000},"page":"615-623","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Systemic Inflammatory Response Index in Cervical Pathologies (Human Papillomavirus and Cervical Neoplasia) and its Prognostic Value in Disease Prediction"],"prefix":"10.4103","volume":"28","author":[{"given":"N","family":"Cim","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Istanbul Haseki Training and Research Hospital, Republic of Turkey Ministry of Health, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Ayguler","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Istanbul Haseki Training and Research Hospital, Republic of Turkey Ministry of Health, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Gunal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Istanbul Haseki Training and Research Hospital, Republic of Turkey Ministry of Health, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Cim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Islahiye State Hospital, Republic of Turkey Ministry of Health, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Argun","family":"Atalmis","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology, Basaksehir Cam and Sakura City Hospital, Republic of Turkey Ministry of Health, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Cetin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Istanbul Haseki Training and Research Hospital, Republic of Turkey Ministry of Health, Istanbul, Turkey"},{"name":"Department of Obstetrics and Gynecology, Faculty of Hamidiye Medicine, University of Health Sciences, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"R1-20260422","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1056\/NEJMcp1210379","article-title":"Clinical practice. 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