{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T03:42:11Z","timestamp":1794368531872,"version":"4.9.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate effectiveness and safety of accelerated corneal cross-linking (CXL) in the treatment of keratoconus in pediatric patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Tertiary care hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In this study, case series of patients 18 years old or younger with progressive keratoconus who underwent accelerated CXL were observed. All consecutive patients underwent accelerated CXL with setting of 9 mW\/cm\n                      <jats:sup>2<\/jats:sup>\n                      for 10-minute Ultraviolet-A radiation, corresponding to a total dose of 5.4 J\/cm\n                      <jats:sup>2<\/jats:sup>\n                      . Preoperative and 12-month postoperative data including uncorrected distance visual acuity (UDVA), best-corrected distance visual acuity (BDVA), keratometry (K) measurements, mean spherical, and cylindrical refraction were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The group consisted of 28 eyes from 14 patients (10 males and 4 females). Mean age of the patients was 16.9 years (11-18 years). UDVA did not change significantly from 0.71 \u00b1 0.54 to 0.65 \u00b1 0.43 logMAR (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.41). BDVA improved significantly from 0.30 \u00b1 0.35 to 0.21 \u00b1 0.34 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.006). The steep K-value decreased from 48.4 \u00b1 4.3 to 48.0 \u00b1 4.6 diopters, but there was no significant change in steep K-value (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.35). There was no significant change in flat and mean K-value (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). Mean spherical and cylindrical refraction were not significantly altered (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). One patient with vernal keratoconjunctivitis showed sterile peripheral corneal infiltrates. Patient was treated with topical corticosteroids, antibiotics, and artificial tears.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The findings revealed that accelerated CXL is an effective and safe procedure that halts the progression of keratoconus in pediatric patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_598_22","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:01:50Z","timestamp":1707177710000},"page":"131-135","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Accelerated Corneal Cross-linking in Pediatric Patients with Progressive Keratoconus: 12-Month Follow-up 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