{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:00:03Z","timestamp":1787169603677,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"\n Context:<\/jats:title>\n Colorectal cancer represents the third leading cause of cancer-related mortality worldwide. Emerging evidence suggests distinct biological differences between right-sided colon cancer (RCC) and left-sided colon cancer (LCC), although their prognostic significance remains controversial.<\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n To compare clinicopathological features and oncological outcomes between RCC and LCC following mesocolic resection and to identify independent prognostic factors.<\/jats:p>\n <\/jats:sec>\n \n Setting and Design:<\/jats:title>\n A retrospective cohort study was conducted at a tertiary center between January 2010 and December 2020.<\/jats:p>\n <\/jats:sec>\n \n Methods and Materials:<\/jats:title>\n A total of 948 patients with colon adenocarcinoma underwent curative resection and were categorized as RCC (n = 335) or LCC (n = 613), with analysis of demographic, pathological, and survival data focusing on overall survival and disease-free survival endpoints.<\/jats:p>\n <\/jats:sec>\n \n Statistical Analysis Used:<\/jats:title>\n \n Continuous variables were compared using\n t<\/jats:italic>\n -test or Mann\u2013Whitney U test. Categorical variables were analyzed using Chi-square or Fisher\u2019s exact test. Univariate and multivariate Cox regression was performed to identify prognostic factors.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n RCC patients were older (62.6 \u00b1 14.8 vs 59.3 \u00b1 14.4 years,\n P<\/jats:italic>\n < 0.001) and more frequently female (48.1% vs 37.0%,\n P<\/jats:italic>\n < 0.001). RCC tumors showed more aggressive characteristics: poor differentiation (15.8% vs 7.7%), advanced T-stage (97.6% vs 83.9%) (both\n P<\/jats:italic>\n < 0.001). At median follow-up of 78.4 months, RCC demonstrated inferior survival with OS 79.1% vs 85.0% (\n P<\/jats:italic>\n = 0.031) and DFS 74.0% vs 78.0% (\n P<\/jats:italic>\n = 0.042). Multivariate analysis confirmed right-sided location as an independent adverse prognostic factor (Hazard Ratio = 1.45, 95% Confidence Interval: 1.05\u20132.01,\n P<\/jats:italic>\n = 0.024).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n RCC showed more aggressive features and worse survival than LCC, suggesting tumor sidedness as an independent prognostic factor.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/njcp.njcp_602_25","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T10:00:19Z","timestamp":1770112819000},"page":"50-56","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Oncologic Outcomes after Mesocolic Resection in Right- and Left-Sided Colon Cancer"],"prefix":"10.4103","volume":"29","author":[{"given":"M","family":"Y\u0131lmaz","sequence":"first","affiliation":[{"name":"Department of General Surgery\/Surgical Oncology, Mersin University Faculty of Medicine, Mersin, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"\u00d6zcan","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Mersin University Faculty of Medicine, Mersin, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Benli","sequence":"additional","affiliation":[{"name":"Department of General Surgery\/Surgical Oncology, Mersin University Faculty of Medicine, Mersin, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"R1-20260420","first-page":"89","article-title":"Epidemiology of colorectal cancer: \u0130ncidence, mortality, survival, and risk factors","volume":"14","author":"Rawla","year":"2019","journal-title":"Prz Gastroenterol"},{"key":"R2-20260420","doi-asserted-by":"crossref","first-page":"779","DOI":"10.7326\/0003-4819-113-10-779","article-title":"Colorectal cancer: Evidence for distinct genetic categories based on proximal or distal tumor location","volume":"113","author":"Bufill","year":"1990","journal-title":"Ann Intern Med"},{"key":"R3-20260420","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ijc.10635","article-title":"Are there two sides to colorectal cancer?","volume":"101","author":"Iacopetta","year":"2002","journal-title":"Int J Cancer"},{"key":"R4-20260420","doi-asserted-by":"crossref","first-page":"6470","DOI":"10.3748\/wjg.v21.i21.6470","article-title":"Different treatment strategies and molecular features between right-sided and left-sided colon cancers","volume":"21","author":"Shen","year":"2015","journal-title":"World J Gastroenterol"},{"key":"R5-20260420","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.12998\/wjcc.v8.i8.1424","article-title":"Clinicopathological differences and correlations between right and left colon cancer","volume":"8","author":"Kalantzis","year":"2020","journal-title":"World J Clin Cases"},{"key":"R6-20260420","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12957-021-02240-3","article-title":"Effect of sidedness on survival among patients with early-stage colon cancer: a SEER-based propensity score matching analysis","volume":"19","author":"Huang","year":"2021","journal-title":"World J Surg Oncol"},{"key":"R7-20260420","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.3390\/jpm14121153","article-title":"Impact of sidedness of colon cancer on epidemiological, clinical presentation, surgical, pathological, and oncologic outcomes","volume":"14","author":"Moraes Filho","year":"2024","journal-title":"J Pers Med"},{"key":"R8-20260420","doi-asserted-by":"crossref","first-page":"4369","DOI":"10.1007\/s10238-023-01120-2","article-title":"Prognostic value of primary tumor location in colorectal cancer: An updated meta-analysis","volume":"23","author":"Gholamalizadeh","year":"2023","journal-title":"Clin Exp Med"},{"key":"R9-20260420","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/DCR.0b013e3181c703a4","article-title":"Comparison of 17,641 patients with right- and left-sided colon cancer: Differences in epidemiology, perioperative course, histology, and survival","volume":"53","author":"Benedix","year":"2010","journal-title":"Dis Colon Rectum"},{"key":"R10-20260420","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3390\/cancers17030537","article-title":"Right-sided versus left-sided colon cancer-A 5-year single-center observational study","volume":"17","author":"Szostek","year":"2025","journal-title":"Cancers (Basel)"},{"key":"R11-20260420","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1245\/s10434-020-09116-y","article-title":"Does side really matter? 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