{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:52:59Z","timestamp":1787961179762,"version":"build-2784847793"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction and Purpose:<\/jats:title>\n                    <jats:p>In this prospective study, we aim to evaluate the effects of antibiotherapy on pentraxin-3 (PTX3), C-reactive protein (CRP), and interleukin-6 (IL-6) levels in patients with sepsis and septic shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>In our study, CRP, procalcitonin, IL-6, and PTX3 levels at initial and 48 hours of the antibiotherapy of patients who were admitted to the pediatric intensive care unit (PICU) with the diagnosis of sepsis and septic shock between June 2020 and March 2021 were compared. Patients were compared with the age-appropriate case-control group formed from the patients who received pre-operative routines to investigate the diagnostic value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      CRP, IL-6, and PTX3 levels of the patients were significantly higher compared to controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). After the 48\n                      <jats:sup>th<\/jats:sup>\n                      hour of treatment compared to initial CRP, lactate and PCT levels were significantly lower (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). The IL-6 and PCT levels were significantly higher in patients with mortality than in surviving patients. Surviving patients showed a significant decrease in CRP level at the 48\n                      <jats:sup>th<\/jats:sup>\n                      hour. IL-6 levels of patients with septic shock were significantly higher than those with sepsis (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.010;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). In the diagnosis of septic shock, the area under curve was 0.785 for IL-6 and the standard deviation was 0.09 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002, cut-off value, &gt;32 pg\/mL, 88.9% sensitivity, 65.6% specifity).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The results of this study indicated that IL-6 level is an appropriate biomarker with high specificity in the diagnosis of sepsis and septic shock and in evaluating the response to treatment and determining the prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_615_23","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T01:14:48Z","timestamp":1711415688000},"page":"317-324","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Diagnostic and Prognostic Value of Pentraxin 3, Interleukin-6, CRP, and Procalcitonin Levels in Patients with Sepsis and Septic Shock"],"prefix":"10.4103","volume":"27","author":[{"given":"B","family":"Palal\u0131o\u011flu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Health Sciences Zeynep Kamil Training and Research Hospital, Uskudar Opr. Dr. Burhanettin Ustunel Cad. No:10, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Erdo\u011fan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care, University of Health Sciences Umraniye Training and Research Hospital, Elmal\u0131kent, Adem Yavuz Cd., Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Atay","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care, University of Health Sciences Umraniye Training and Research Hospital, Elmal\u0131kent, Adem Yavuz Cd., Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HC","family":"Tugrul","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care, University of Health Sciences Umraniye Training and Research Hospital, Elmal\u0131kent, Adem Yavuz Cd., Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6F","family":"\u00d6zer","sequence":"additional","affiliation":[{"name":"Bezmialem Vakif University, Department of Biochemistry Adnan Menderes Bulvar\u0131 (Vatan Cad.) 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