{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:26:20Z","timestamp":1787772380578,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aim:<\/jats:title>\n                    <jats:p>Preeclampsia, a pregnancy complication associated with significant maternal and perinatal mortality and morbidity, has been found to be closely linked to dysfunction in the blood coagulation\u2013fibrinolysis system. However, the relationship between hematologic data and severity and onset time of preeclampsia remains unclear. This study aimed to identify specific hematologic parameters in both preeclamptic and normotensive pregnant women and determine their potential significance in the pathogenesis of preeclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A total of 112 patients with gestational hypertension disease were divided into two groups: early-onset preeclampsia (32 cases) and late-onset preeclampsia (80 cases). A control group of 82 normotensive pregnant women matched for age and parity was also selected. Blood samples were collected from all participants to test for specific hematologic parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mild and severe preeclampsia were associated with lower hemoglobin level (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03, respectively), higher mean platelet volume (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01, respectively) and fibrinogen (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01, respectively), and shorter prothrombin time (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01, respectively) and activated partial thromboplastin time (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These findings have provided evidence on the hematologic coagulative actors in the pathogenesis and severity of preeclampsia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_645_23","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T02:01:54Z","timestamp":1716948114000},"page":"599-603","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["The Relationship between the Level of Coagulative Function Hypertensive Disorder Complicating Pregnancy"],"prefix":"10.4103","volume":"27","author":[{"given":"Z","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Osteology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nutrition, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,5,29]]},"reference":[{"key":"R1-20260505","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet"},{"key":"R3-20260505","first-page":"533","article-title":"Pregnancy-related mortality from preeclampsia and eclampsia","volume":"97","author":"Mackay","year":"2001","journal-title":"Obstet Gynecol"},{"key":"R4-20260505","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0140-6736(00)03577-7","article-title":"Pathogenesis and genetics of pre-eclampsia","volume":"357","author":"Roberts","year":"2001","journal-title":"Lancet"},{"key":"R5-20260505","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1179\/1607845413Y.0000000098","article-title":"Preeclampsia: Are platelet count and indices useful for its prognostic?","volume":"18","author":"Freitas","year":"2013","journal-title":"Hematology"},{"key":"R6-20260505","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1067\/mob.2000.104224","article-title":"Predictors of neonatal outcome in women with severe preeclampsia or eclampsia between 24 and 33 weeks\u2019 gestation","volume":"182","author":"Witlin","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"R7-20260505","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1080\/10641950701548240","article-title":"Fibrinogen concentration and factor VIII activity in women with preeclampsia","volume":"26","author":"Williams","year":"2007","journal-title":"Hypertens Pregnancy"},{"key":"R8-20260505","first-page":"364","article-title":"Reducing unnecessary coagulation testing in hypertensive disorders of pregnancy","volume":"94","author":"Barron","year":"1999","journal-title":"Obstet Gynecol"},{"key":"R9-20260505","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00404-003-0596-4","article-title":"Coagulation inhibitors in preeclamptic pregnant women","volume":"271","author":"Osmana\u011fao\u011flu","year":"2005","journal-title":"Arch Gynecol Obstet"},{"key":"R10-20260505","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.thromres.2004.08.004","article-title":"Haemostatic changes in pregnancy","volume":"114","author":"Brenner","year":"2004","journal-title":"Thromb Res"},{"key":"R11-20260505","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1055\/s-0038-1661167","article-title":"Haemostasis in normal pregnancy","volume":"52","author":"Stirling","year":"1984","journal-title":"Thromb Haemost"},{"key":"R12-20260505","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1055\/s-0038-1661154","article-title":"The fast inhibitor of tissue plasminogen activator in plasma during pregnancy","volume":"52","author":"Wiman","year":"1984","journal-title":"Thromb Haemost"},{"key":"R13-20260505","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nrneph.2014.102","article-title":"Pre-eclampsia part 1: Current understanding of its pathophysiology","volume":"10","author":"Chaiworapongsa","year":"2014","journal-title":"Nat Rev Nephrol"},{"key":"R14-20260505","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1097\/01.AOG.0000285995.41769.83","article-title":"Perinatal and maternal outcomes in women with sickle or hemoglobin C trait","volume":"110","author":"Tita","year":"2007","journal-title":"Obstet Gynecol"},{"key":"R15-20260505","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ijgo.2005.07.008","article-title":"Maternal and perinatal outcome in patients with severe anemia in pregnancy","volume":"91","author":"Patra","year":"2005","journal-title":"Int J Gynaecol Obstet"},{"key":"R16-20260505","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00404-010-1728-2","article-title":"Iron status parameters in preeclamptic women","volume":"284","author":"Siddiqui","year":"2011","journal-title":"Arch Gynecol Obstet"},{"key":"R17-20260505","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00404-005-0013-2","article-title":"Erythropoietin concentration among patients with and without preeclampsia","volume":"273","author":"Hershkovitz","year":"2005","journal-title":"Arch Gynecol Obstet"},{"key":"R18-20260505","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/0002-9378(86)90476-X","article-title":"Longitudinal study of platelet indices during normal pregnancy","volume":"154","author":"Tygart","year":"1986","journal-title":"Am J Obstet Gynecol"},{"key":"R19-20260505","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1046\/j.1365-2362.2000.00753.x","article-title":"The use of platelet density and volume measurements to estimate the severity of pre-eclampsia","volume":"30","author":"J\u00e4remo","year":"2000","journal-title":"Eur J Clin Invest"},{"key":"R20-20260505","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.preghy.2019.08.003","article-title":"Platelet count and mean platelet volume predict atypical pre-eclampsia","volume":"18","author":"Zhang","year":"2019","journal-title":"Pregnancy Hypertens"},{"key":"R21-20260505","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1056\/NEJM199008163230710","article-title":"Platelets and the beginnings of preeclampsia","volume":"323","author":"Redman","year":"1990","journal-title":"N Engl J Med"},{"key":"R22-20260505","first-page":"146","article-title":"Increased platelet volume and aggregation precede the onset of preeclampsia","volume":"83","author":"Hutt","year":"1994","journal-title":"Obstet Gynecol"},{"key":"R23-20260505","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00001721-199603000-00011","article-title":"Platelet size: Measurement, physiology and vascular disease","volume":"7","author":"Bath","year":"1996","journal-title":"Blood Coagul Fibrinolysis"},{"key":"R24-20260505","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/0002-9378(89)90378-5","article-title":"Can platelet volume predict progressive hypertensive disease in pregnancy?","volume":"161","author":"Walker","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"R25-20260505","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/pd.2126","article-title":"Longitudinal study of platelet size changes in gestation and predictive power of elevated MPV in development of pre-eclampsia","volume":"28","author":"Dundar","year":"2008","journal-title":"Prenat Diagn"},{"key":"R26-20260505","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF02110019","article-title":"Hemoconcentration and pre-eclampsia","volume":"231","author":"Heilmann","year":"1981","journal-title":"Arch Gynecol"},{"key":"R27-20260505","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0020-7292(94)90564-9","article-title":"Clotting inhibitors and fibronectin as potential markers in preeclampsia","volume":"47","author":"Paternoster","year":"1994","journal-title":"Int J Gynaecol Obstet"},{"key":"R28-20260505","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF02718370","article-title":"Markers for endothelial injury, clotting and platelet activation in preeclampsia","volume":"251","author":"Saleh","year":"1992","journal-title":"Arch Gynecol Obstet"},{"key":"R29-20260505","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.thromres.2003.08.025","article-title":"Increased high molecular weight fibrinogen in pre-eclampsia","volume":"111","author":"Manten","year":"2003","journal-title":"Thromb Res"}],"container-title":["Nigerian Journal of Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/njcp.njcp_645_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:41:45Z","timestamp":1787769705000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/njcp.njcp_645_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/njcp.njcp_645_23","relation":{},"ISSN":["1119-3077","2229-7731"],"issn-type":[{"value":"1119-3077","type":"print"},{"value":"2229-7731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"2023-08-31","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}