{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:34:27Z","timestamp":1787762067601,"version":"build-2784847793"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim:<\/jats:title>\n                    <jats:p>The aim of this clinic study was to investigate the effect of piezoincision on the rate of mandibular molar mesialization using clinical, radiological, and biochemical methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Twenty-one patients requiring mandibular first molar extraction and second molar mesialization were included in the study which was designed as split-mouth study. Piezoincision was performed on the buccal surface of alveolar bone following regional alignment to the randomly selected side. 150 g of force was applied to the second molar teeth using mini-screw-supported anchorage after the piezoincision. Cone beam computed tomography (CBCT), gingival crevicular fluid (GCF) and digital model records of the patients were obtained. Two- and three-dimensional measurements were performed and compared on the CBCT images in a study which lasted 24 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>According to the model analysis, the canine-second molar distance was consistently reduced and a greater decrease was measured on the experimental group (p &lt; 0.05). Second molar mesial rotations increased in both groups (p &lt; 0.001). Two-dimensional measurements on CBCT images showed increased mesial and buccal tipping of second molars in experimental group (p &lt; 0.001). There was a significant increase in mesialization measurements of experimental group (p &lt; 0.001). Three-dimensional measurements on the CBCT images showed a decrease of root length in both groups (p &lt; 0.001), and a greater decrease was found in the experimental group (p &lt; 0.001). When intra-group changes in GCF results were examined, it was observed that there was no significant change in osteoprotegerin (OPG) values over time in experimental group (p = 0.148).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The piezoincision technique provided acceleration of mandibular molar mesialization and did not cause further damage to the buccal alveolar bone. Piezoincision can be used as a safe method in the mandibular molar region.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_657_22","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T06:02:13Z","timestamp":1689314533000},"page":"720-730","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Piezoincision on the Rate of Mandibular Molar Mesialization: A Randomised Clinical Trial"],"prefix":"10.4103","volume":"26","author":[{"given":"M","family":"Ogrenim","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, Ayd\u0131n Adnan Menderes University, Ayd\u0131n, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MG","family":"Cesur","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, Ayd\u0131n Adnan Menderes University, Ayd\u0131n, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Demetoglu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ayd\u0131n Adnan Menderes University, Ayd\u0131n, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZP","family":"Yucel","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry, Giresun University, Giresun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Avc\u0131","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Ondokuz May\u0131s University, Samsun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,7,14]]},"reference":[{"key":"R1-20240907","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ajodo.2008.09.028","article-title":"Pretreatment characteristics associated with orthodontic treatment duration","volume":"137","author":"Fisher","year":"2010","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"R2-20240907","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1053\/j.sodo.2008.03.002","article-title":"White spot lesions:Formation, prevention, and treatment","volume":"14","author":"Bishara","year":"2008","journal-title":"Semin Orthod"},{"key":"R3-20240907","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.ajodo.2007.01.032","article-title":"External apical root resorption in patients treated with conventional and self-ligating brackets","volume":"134","author":"Pandis","year":"2008","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"R4-20240907","first-page":"79","article-title":"The relationship between the length of orthodontic treatment and patient compliance","volume":"92","author":"Royko","year":"1999","journal-title":"Fogorv Sz"},{"key":"R5-20240907","first-page":"342","article-title":"Piezocision:A minimally invasive, periodontally accelerated orthodontic tooth movement procedure","volume":"30","author":"Dibart","year":"2009","journal-title":"Compend Contin Educ Dent"},{"key":"R6-20240907","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0030-4220(59)90153-7","article-title":"Surgical operations on the alveolar ridge to correct occlusal abnormalities","volume":"12","author":"K\u00f6le","year":"1959","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"R7-20240907","doi-asserted-by":"crossref","first-page":"74","DOI":"10.2319\/111914-830.1","article-title":"Vibratory stimulation increases interleukin-1 beta secretion during orthodontic tooth movement","volume":"86","author":"Leethanakul","year":"2015","journal-title":"Angle Orthod"},{"key":"R8-20240907","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0889-5406(87)90465-3","article-title":"Effect of pulsed electromagnetic fields on orthodontic tooth movement","volume":"91","author":"Stark","year":"1987","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"R9-20240907","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/00220345920710010901","article-title":"The effect of local application of 1, 25-dihydroxycholecalciferol on osteoclast numbers in orthodontically treated rats","volume":"71","author":"Takano-Yamamoto","year":"1992","journal-title":"J Dent Res"},{"key":"R10-20240907","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/BF02555981","article-title":"A model for investigating the local action of bone-acting agents in vivo:Effects of hPTH (1\u201334) on the secondary spongiosa in the rat","volume":"47","author":"Takano-Yamamoto","year":"1990","journal-title":"Calcif Tissue Int"},{"key":"R11-20240907","first-page":"9","article-title":"Rapid orthodontics with alveolar reshaping:Two case reports of decrowding","volume":"21","author":"Wilcko","year":"2001","journal-title":"Int J Periodontics Restorative Dent"},{"key":"R12-20240907","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.ajodo.2003.06.002","article-title":"Comparison of the effects of 1, 25 dihydroxycholecalciferol and prostaglandin E2 on orthodontic tooth movement","volume":"125","author":"Kale","year":"2004","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"R13-20240907","first-page":"118","article-title":"Orthodontic tooth movement in the prednisolone-treated rat","volume":"70","author":"Ong","year":"2000","journal-title":"Angle Orthod"},{"key":"R14-20240907","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/sj.gt.3302707","article-title":"Local RANKL gene transfer to the periodontal tissue accelerates orthodontic tooth movement","volume":"13","author":"Kanzaki","year":"2006","journal-title":"Gene Ther"},{"key":"R15-20240907","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.ajodo.2006.01.046","article-title":"Periodontal tissue activation by vibration:Intermittent stimulation by resonance vibration accelerates experimental tooth movement in rats","volume":"133","author":"Nishimura","year":"2008","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"R16-20240907","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1079-2104(99)70108-3","article-title":"The effects of operator technique and bur design on temperature during osseous preparation for osteosynthesis self-tapping screws","volume":"88","author":"Kerawala","year":"1999","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R17-20240907","first-page":"52","article-title":"Piezosurgery:An increasing role in dental hard tissue surgery","volume":"18","author":"Walsh","year":"2007","journal-title":"Australas Med J"},{"key":"R18-20240907","first-page":"207","article-title":"Technological characteristics and clinical indications of piezoelectric bone surgery","volume":"53","author":"Vercellotti","year":"2004","journal-title":"Minerva Stomatol"},{"key":"R19-20240907","first-page":"325","article-title":"Orthodontic microsurgery:A new surgically guided technique for dental movement","volume":"27","author":"Vercellotti","year":"2007","journal-title":"Int J Periodontics Restorative Dent"},{"key":"R20-20240907","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ajodo.2010.07.031","article-title":"Protraction of mandibular second and third molars into missing first molar spaces for a patient with an anterior open bite and anterior spacing","volume":"141","author":"Baik","year":"2012","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"R22-20240907","doi-asserted-by":"crossref","first-page":"469.e1","DOI":"10.1016\/j.ajodo.2005.10.007","article-title":"Cellular, molecular, and tissue-level reactions to orthodontic force","volume":"129","author":"Krishnan","year":"2006","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"R23-20240907","doi-asserted-by":"crossref","first-page":"241","DOI":"10.14219\/jada.archive.2012.0148","article-title":"Evidence supporting the use of cone-beam computed tomography in orthodontics","volume":"143","author":"van Vlijmen","year":"2012","journal-title":"J Am Dent Assoc"},{"key":"R24-20240907","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2319\/012215-49.1","article-title":"Accelerated tooth movement with piezocision and its periodontal-transversal effects in patients with Class II malocclusion","volume":"86","author":"Aksakalli","year":"2015","journal-title":"Angle Orthod"},{"key":"R25-20240907","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1053\/j.sodo.2015.06.002","article-title":"Micro-osteoperforations:Minimally invasive accelerated tooth movement","volume":"21","author":"Alikhani","year":"2015","journal-title":"Semin Orthod"},{"key":"R26-20240907","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1053\/j.sodo.2015.06.003","article-title":"Piezocision\u2122-assisted orthodontics:Past, present, and future","volume":"21","author":"Dibart","year":"2015","journal-title":"Semin Orthod"},{"key":"R27-20240907","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/ejo\/cjy042","article-title":"Efficacy of piezocision-based flapless corticotomy in the orthodontic correction of severely crowded lower anterior teeth:A randomized controlled trial","volume":"41","author":"Gibreal","year":"2019","journal-title":"Eur J Orthod"},{"key":"R28-20240907","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.ajodo.2014.07.007","article-title":"Accelerated orthodontic tooth movement:Molecular mechanisms","volume":"146","author":"Huang","year":"2014","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"R29-20240907","doi-asserted-by":"crossref","first-page":"37","DOI":"10.17116\/stomat20189704137","article-title":"The mesialization of molars of the lower jaw after performance surgical manipulation with using miniscrew anchorage approach","volume":"97","author":"Arsenina","year":"2018","journal-title":"Stomatologiia"},{"key":"R30-20240907","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ajodo.2015.09.029","article-title":"Evaluation of corticotomy-facilitated orthodontics and piezocision in rapid canine retraction","volume":"149","author":"Abbas","year":"2016","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"R31-20240907","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ajodo.2009.04.028","article-title":"Miniscrew implant-supported maxillary canine retraction with and without corticotomy-facilitated orthodontics","volume":"139","author":"Aboul-Ela","year":"2011","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"R32-20240907","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.adaj.2015.04.025","article-title":"Mandibular molar protraction as an alternative treatment for edentulous spaces:Focus on changes in root length and alveolar bone height","volume":"146","author":"Kim","year":"2015","journal-title":"J Am Dent Assoc"},{"key":"R33-20240907","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.ajodo.2016.12.005","article-title":"Apical root resorption due to mandibular first molar mesialization:A split-mouth study","volume":"151","author":"Winkler","year":"2017","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"R34-20240907","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.ajodo.2009.06.021","article-title":"Root resorption associated with orthodontic tooth movement:A systematic review","volume":"137","author":"Weltman","year":"2010","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"R35-20240907","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/ejo\/cjt079","article-title":"Tissue response during Piezocision-assisted tooth movement:A histological study in rats","volume":"36","author":"Dibart","year":"2014","journal-title":"Eur J Orthod"},{"key":"R36-20240907","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/ejo\/cjx015","article-title":"Efficiency of piezosurgery technique in miniscrew supported en-masse retraction:A single-centre, randomized controlled trial","volume":"39","author":"Tun\u00e7er","year":"2017","journal-title":"Eur J Orthod"},{"key":"R37-20240907","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40510-019-0275-z","article-title":"Effect of mandibular first molar mesialization on alveolar bone height:A split mouth study","volume":"20","author":"G\u00f6llner","year":"2019","journal-title":"Prog Orthod"},{"key":"R38-20240907","first-page":"354","article-title":"Extraction vs nonextraction:Arch widths and smile esthetics","volume":"73","author":"Kim","year":"2003","journal-title":"Angle Orthod"},{"key":"R39-20240907","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s41547-019-00055-w","article-title":"Comparison between the effect of low-level laser therapy and corticotomy-facilitated orthodontics on RANKL release during orthodontic tooth movement:A randomized controlled trial","volume":"3","author":"Sedky","year":"2019","journal-title":"Laser Dent Sci"},{"key":"R40-20240907","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ajodo.2010.09.026","article-title":"Mechanism of action and morphologic changes in the alveolar bone in response to selective alveolar decortication\u2013facilitated tooth movement","volume":"139","author":"Baloul","year":"2011","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"R41-20240907","doi-asserted-by":"crossref","first-page":"770.e1","DOI":"10.1016\/j.ajodo.2009.05.015","article-title":"Tissue responses in corticotomy- and osteotomy-assisted tooth movements in rats:histology and immunostaining","volume":"136","author":"Wang","year":"2009","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"R42-20240907","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.archoralbio.2005.04.005","article-title":"Immunohistochemical evaluation of osteoclast recruitment during experimental tooth movement in young and adult rats","volume":"50","author":"Ren","year":"2005","journal-title":"Arch Oral Biol"}],"container-title":["Nigerian Journal of Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/njcp.njcp_657_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:14:17Z","timestamp":1787760857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/njcp.njcp_657_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/njcp.njcp_657_22","relation":{},"ISSN":["1119-3077","2229-7731"],"issn-type":[{"value":"1119-3077","type":"print"},{"value":"2229-7731","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"2022-09-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}