{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:34:20Z","timestamp":1791819260579,"version":"4.3.4"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to investigate the effectiveness of the liquid PRF-DBBM mixture on new bone formation in maxillary sinus augmentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>Seven patients requiring two-stage bilateral maxillary sinus augmentation were included in the study. The patients were selected according to the criteria of having an alveolar bone height of at least 2 mm in the atrophic region. The elevated sinus cavities were randomly grafted with DBBM + liquid PRF (test) or DBBM alone (control) in a split-mouth design. Bone samples were collected during implant surgery with a trephine bur for histomorphometric evaluation after 4 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In the control group, the newly formed bone was 39.49%, the mature bone was 15.66%, the residual graft was 15.62%, and the fibrous tissue ratio 28.59%, while in the test group, the newly formed bone (NFB) was 45.95%, the mature bone was 14.40%, the residual graft was 10.32%, and the fibrous tissue was 29.31%. No statistically significant difference was found between the groups in terms of the parameters studied (p &gt; 0.05). The mean osteocalcin score in the control group was 2.70 \u00b1 0.39, while it was 2.81 \u00b1 0.36 in the test group. There was no statistically significant difference between the averages of osteocalcin scores of the groups (p &gt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The results of our study showed that DBBM is a reliable graft material for maxillary sinus augmentation even in the early period. Combining of DBBM with liquid-PRF contributed to new bone formation over a four-month period, but this contribution was not statistically significant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_692_20","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:57:43Z","timestamp":1692579463000},"page":"1366-1372","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of the Effectiveness of Liquid Platelet-Rich Fibrin and Deproteinized Bovine Bone Mineral Mixture on Newly Formed Bone in Maxillary Sinus Augmentation"],"prefix":"10.4103","volume":"24","author":[{"given":"HO","family":"Irdem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Dolanmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Esen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"\u00dcnl\u00fckal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"\u015eimsek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-17-20240907","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0011-8532(22)02107-3","article-title":"Maxillary and sinus implant reconstructions","volume":"30","author":"Tatum","year":"1986","journal-title":"Dent Clin North Am"},{"key":"R2-17-20240907","first-page":"199","article-title":"Maxillary sinus: Anatomy, physiology, surgery, and bone grafting related to implantology-eleven years of surgical experience (1979-1990)","volume":"16","author":"Chanavaz","year":"1990","journal-title":"J Oral Implantol"},{"key":"R3-17-20240907","first-page":"613","article-title":"Grafting of the maxillary sinus floor with autogenous marrow and bone","volume":"38","author":"Boyne","year":"1980","journal-title":"J Oral Surg"},{"key":"R4-17-20240907","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1708-8208.2007.00050.x","article-title":"A literature review on biomaterials in sinus augmentation procedures","volume":"9","author":"Browaeys","year":"2007","journal-title":"Clin Implant Dent Relat Res"},{"key":"R5-17-20240907","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.msec.2010.03.012","article-title":"Maxillary sinus floor augmentation on humans: Packing simulations and 8 months histomorphometric comparative study of anorganic bone matrix and \u03b2-tricalcium phosphate particles as grafting materials","volume":"30","author":"Martinez","year":"2010","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"R6-17-20240907","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jcms.2011.04.020","article-title":"Effects of Choukroun's platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: A histological and histomorphometric study","volume":"40","author":"Zhang","year":"2012","journal-title":"J Craniomaxillofac Surg"},{"key":"R7-17-20240907","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1016\/j.jcms.2013.05.029","article-title":"A comparative study of the regenerative effect of sinus bone grafting with platelet-rich fibrin-mixed Bio-Oss\u00ae and commercial fibrin-mixed Bio-Oss\u00ae: An experimental study","volume":"42","author":"Xuan","year":"2014","journal-title":"J Craniomaxillofac Surg"},{"key":"R8-17-20240907","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/cid.12713","article-title":"Evaluation of L-PRF combined with deproteinized bovine bone mineral for early implant placement after maxillary sinus augmentation: A randomized clinical trial","volume":"21","author":"Pichotano","year":"2019","journal-title":"Clin Implant Dent Relat Res"},{"key":"R9-17-20240907","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1097\/SCS.0000000000005339","article-title":"Histological evaluation of the effects of growth factors in a fibrin network on bone regeneration","volume":"30","author":"Cakir","year":"2019","journal-title":"J Craniofac Surg"},{"key":"R10-17-20240907","first-page":"23","article-title":"Growth Factors and fibrin network to improve the particles bone grafting. 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