{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:17:25Z","timestamp":1787764645212,"version":"build-2784847793"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n Testicular torsion causes ischemic injury, and torsion causes reperfusion injury.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n Evaluating the role of augmenter of liver regeneration (ALR) in testicular ischemia and ischemia\/reperfusion injury.<\/jats:p>\n <\/jats:sec>\n \n Materials and Method(s):<\/jats:title>\n \n Seventy-eight (78) healthy Wistar albino male rats were randomly divided into four groups; control (C) (\n n<\/jats:italic>\n = 6), sham (S) (\n n<\/jats:italic>\n = 24), torsion (T) (\n n<\/jats:italic>\n = 24), and torsion\/detorsion (T\/D) (\n n<\/jats:italic>\n = 24). S, T, and T\/D groups were divided into four subgroups (\n n<\/jats:italic>\n = 6) as 1\n st<\/jats:sup>\n , 2\n nd<\/jats:sup>\n , 3\n rd<\/jats:sup>\n , and 4\n th<\/jats:sup>\n hours. Blood, tissue ALR, and histology analyses were performed between groups and subgroups.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The increase in plasma ALR values at the 3\n rd<\/jats:sup>\n and 4\n th<\/jats:sup>\n hours compared to the 1\n st<\/jats:sup>\n hour in the T group were significant (\n P<\/jats:italic>\n < 0.01,\n P<\/jats:italic>\n < 0.001, respectively). In the T\/D group, a significant increase was observed in plasma ALR values at the 3\n rd<\/jats:sup>\n and 4\n th<\/jats:sup>\n hours compared to the 1\n st<\/jats:sup>\n hour (\n P<\/jats:italic>\n < 0.05,\n P<\/jats:italic>\n < 0.001, respectively). Plasma ALR values at the 1\n st<\/jats:sup>\n , 2\n nd<\/jats:sup>\n , 3\n rd<\/jats:sup>\n , and 4\n th<\/jats:sup>\n hours were higher in the T and T\/D groups than in the C group (\n P<\/jats:italic>\n < 0.001,\n P<\/jats:italic>\n < 0.05, respectively). Plasma ALR values were higher in the T group at the 1\n st<\/jats:sup>\n , 2\n nd<\/jats:sup>\n , 3\n rd<\/jats:sup>\n , and 4\n th<\/jats:sup>\n hours than in the S group (\n P<\/jats:italic>\n < 0.05). A significant increase was observed in tissue ALR at the 3\n rd<\/jats:sup>\n and 4\n th<\/jats:sup>\n hours than at the 1\n st<\/jats:sup>\n hour in the T group (\n P<\/jats:italic>\n < 0.05,\n P<\/jats:italic>\n < 0.001, respectively). A significant increase was observed in tissue ALR at the 3\n rd<\/jats:sup>\n and 4\n th<\/jats:sup>\n hours than in the 1\n st<\/jats:sup>\n hour in the T\/D group (\n P<\/jats:italic>\n < 0.05,\n P<\/jats:italic>\n < 0.001, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Discussion:<\/jats:title>\n ALR in plasma and testicular tissue has a potential role in the early diagnosis of testicular torsion and in predicting the prognosis of T and T\/D.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/njcp.njcp_700_22","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T01:22:26Z","timestamp":1690852946000},"page":"963-972","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Role of Augmenter of Liver Regeneration on Testicular Ischemia and Ischemia\/Reperfusion Injury: An Experimental Study"],"prefix":"10.4103","volume":"26","author":[{"given":"N","family":"Kavak","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, University of Health Sciences, D\u0131\u015fkap\u0131 Y\u0131ld\u0131r\u0131m Beyaz\u0131t Training and Research Hospital, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130","family":"G\u00fcler","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Republic of T\u00fcrkiye, Ministry of Health, General Directorate of Public Hospitals, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Akcan","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AA","family":"S\u00fcrel","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Coordinator Head Physician of Turkish Ministry of Health, Ankara City Hospital, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"G\u00fcng\u00f6rer","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Ankara City Hospital, Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Abatay","sequence":"additional","affiliation":[{"name":"Mu\u015f State Hospital, Emergency Medicine, Mu\u015f, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MP","family":"Abatay","sequence":"additional","affiliation":[{"name":"Hask\u00f6y Familiy Heath Center, Mu\u015f, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Balc\u0131","sequence":"additional","affiliation":[{"name":"Ministry of Health, Department of Services, Home Health Services Unit, Speciality of Family Medicine, Ankara, 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