{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:19:15Z","timestamp":1787847555151,"version":"build-2784847793"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Hypothyroidism is a common condition, and thyroid hormones play a key role in metabolism and fat regulation. We examined how levothyroxine affects visceral adipose tissue (VAT) and body composition using dual-energy X-ray absorptiometry in newly diagnosed hypothyroid patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In this prospective observational study, we enrolled 70 adult patients newly diagnosed with either overt hypothyroidism (OH) or subclinical hypothyroidism (SCH). Levothyroxine was started at 1.6 \u00b5g\/kg\/day for OH and 25 \u00b5g\/day for SCH, with doses adjusted every 2 months to reach euthyroidism. Body composition and VAT were assessed at baseline and 2 months after achieving euthyroidism. Results were analyzed using appropriate statistical methods, and a\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value of less than 0.05 was considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The study participants (51 F; 19 M) had a mean age of 36.6 \u00b1 10.7 years, body weight of 63.5 \u00b1 13.6 kg, and a body mass index (BMI) of 25.5 \u00b1 4.2 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . A total of 46 (66%) patients had OH, and 24 (34%) patients had SCH. The mean duration of levothyroxine therapy to achieve euthyroidism in both groups was 7.3 \u00b1 2.2 months. The VAT (gm) did not show a significant change (before 584.7 \u00b1 266.6 and after 596.8 \u00b1 265.3) after achieving euthyroidism (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.1283). No significant difference was seen in either fat mass or lean mass.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Levothyroxine did not significantly alter body composition or VAT during this short observation period. Additional studies with a larger sample size and longer-term follow-up are needed to confirm our findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_718_25","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T01:00:09Z","timestamp":1780016409000},"page":"506-510","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Levothyroxine on Visceral Adipose Tissue\u2014A Prospective, Observational Study"],"prefix":"10.4103","volume":"29","author":[{"given":"SR","family":"Vasamsetti","sequence":"first","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Guddeti","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College and Hospital, Hyderabad, Telangana, 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