{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:38:32Z","timestamp":1786649912827,"version":"build-2736575974"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acute respiratory distress syndrome (ARDS) due to coronovirus disease 2019 (COVID-19) is accompanied by severe hypoxemia and hyperinflammation. Hypoxia-inducible factor (HIF) pathway plays a fundamental role in detecting the hypoxia and developing appropriate responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the role of HIF-1\u03b1 and PHD2 (prolyl hydroxylase domain2) genes in the pathophysiology of severe hypoxemia in COVID-19 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study included 297 patients who developed ARDS due to COVID-19 infection and were admitted into the intensive care unit. APACHEII score, SOFA, vasopressor, dialysis and mechanical ventilation need during treatment, and 30-day mortality were recorded. DNA was isolated from the blood samples by the spin colon method with the QIAamp DNA MiniKit (Cat.No. 51106, QIAGEN, Germany).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Patients were divided into three groups according to their\n                      <jats:italic toggle=\"yes\">Hypoxia Inducible Factor-1\u03b1 (C\/T SNP [<\/jats:italic>\n                      11549465\n                      <jats:italic toggle=\"yes\">])<\/jats:italic>\n                      genotypes. The frequencies were 71.13% for the homozygous CC genotype, 26.4% heterozygous CT genotype, and 2.36% for the homozygous TT genotype. The median age (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.631), APACHE II (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.205), and SOFA (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.077) scores were similar in all three groups. However, the need for dialysis, mechanical ventilation, and vasopressor was less in the homozygous TT-genotype group than in the other groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). The mortality rate was also lower in this group compared to other groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      In conclusion, we revealed the polymorphism in HIF-l\u03b1 and PHD2 genes in ARDS patients due to COVID-19. The rate of\n                      <jats:italic toggle=\"yes\">HIF-l\u03b1<\/jats:italic>\n                      polymorphism was 26.4% for heterozygous CT-genotype and 2.36% for homozygous TT-genotype. The 30-day mortality and adverse outcome (dialysis, vasopressor use, MV need) were significantly lower in TT homozygous. However, none of the polymorphisms in the\n                      <jats:italic toggle=\"yes\">PHD2<\/jats:italic>\n                      genes affected mortality and adverse outcome.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_72_25","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T10:00:18Z","timestamp":1770112818000},"page":"72-78","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["HIF-1\u03b1 is Associated with Improved Survival in Acute Respiratory Distress Syndrome due to COVID-19: A Prospective Study"],"prefix":"10.4103","volume":"29","author":[{"given":"H","family":"Sipahioglu","sequence":"first","affiliation":[{"name":"Department of Intensive Care Unit, Kayseri City Training and Research Hospital, Kayser\u0131, Turk\u0131ye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Koyuncu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kayseri City Training and Research Hospital, Kayser\u0131, Turk\u0131ye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Akal\u0131n","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Medical School of Erciyes University, Kayser\u0131, Turk\u0131ye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Karasu","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Medical School of Erciyes University, Kayser\u0131, Turk\u0131ye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MH","family":"Sipahioglu","sequence":"additional","affiliation":[{"name":"Nephrology, Medical School of Erciyes University, Kayser\u0131, Turk\u0131ye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EE","family":"Eren","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Diseases, Kayseri City Education and Research Hospital, Kayser\u0131, Turk\u0131ye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Onuk","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, Kayseri City Training and Research Hospital, Kayser\u0131, Turk\u0131ye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Elay","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, Gaziantep University, Gaz\u0131antep, Turk\u0131ye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Saatci","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Medical School of Erciyes University, Kayser\u0131, Turk\u0131ye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RC","family":"Y\u00fcksel","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Medical School of Erciyes University, Kayser\u0131, Turk\u0131ye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Gundogan","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Medical School of Erciyes University, Kayser\u0131, Turk\u0131ye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Dundar","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Medical School of Erciyes University, Kayser\u0131, Turk\u0131ye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"R1-20260420","first-page":"2526","article-title":"Acute respiratory distress syndrome: The Berlin 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