{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:29:13Z","timestamp":1786649353186,"version":"build-2736575974"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,8]]},"abstract":"\n Background:<\/jats:title>\n Spontaneous pneumothorax in COVID-19 occurs infrequently but in up to 15% of patients dependent on mechanical ventilation (MV). Pneumothorax-related deaths account for 1% of all COVID-19-related deaths.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n To determine factors associated with pneumothorax in COVID-19 patients and the effect of pneumothorax on early survival.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n This was a retrospective study of 4799 COVID-19\u2013positive hospitalized patients. The groups were homogenized using propensity score matching (PSM) in two groups comprising 67 COVID-19 patients each. The prevalence of pneumothorax was determined. Multiple logistic regression was used to determine factors associated with pneumothorax.\n P<\/jats:italic>\n value < 0.05 was taken as significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The prevalence of pneumothorax in COVID-19 patients was 1.6%. Lung disease, comorbidities, and oxygen support, which were significantly different between the two groups before PSM, were homogenized after PSM. In a univariate analysis, symptom duration (\n P<\/jats:italic>\n \u02c2 0.001), neutrophilia (\n P<\/jats:italic>\n \u02c2 0.001), lymphopenia (\n P<\/jats:italic>\n \u02c2 0.001), neutrophil\u2013lymphocyte ratio (\n P<\/jats:italic>\n = 0.003), ferritin levels (\n P<\/jats:italic>\n = 0.012), D-dimer levels (\n P<\/jats:italic>\n = 0.011), MV support (\n P<\/jats:italic>\n \u02c2 0.001), antibiotherapy (\n P<\/jats:italic>\n \u02c2 0.001), length of hospital stay (\n P<\/jats:italic>\n = 0.009), and death (\n P<\/jats:italic>\n = 0.002) differed significantly between the groups. Pneumothorax had a significant negative effect on survival (32.8% vs. 59.7%,\n P<\/jats:italic>\n = 0.01). In a multivariate regression model, factors associated with pneumothorax were duration of symptoms (Adjusted Odds ratio (AOR) 1.68; 95% Confidence Interval (CI): 1.26-2.25;\n P<\/jats:italic>\n = 0.001), mechanical ventilation (AOR 23.92; 95% CI: 4.12-138.72;\n P<\/jats:italic>\n = <0.001), dual antibiotics (AOR 8.28; 95% CI: 1.56-43.86;\n P<\/jats:italic>\n = 0.013), neutrophilia (AOR: 1.08; 95% CI: 1.02-1.14;\n P<\/jats:italic>\n = 0.011), and lymphopenia (AOR: 0.92; 95% CI: 0.86-0.90;\n P<\/jats:italic>\n = 0.022).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The presence of pneumothorax was associated with poor survival in COVID-19 patients. Patients with a prolonged time from symptom onset to treatment and those dependent on mechanical ventilation in intensive care were in the high risk group for the development of pneumothorax.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/njcp.njcp_785_23","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T05:00:28Z","timestamp":1724648428000},"page":"958-964","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Pneumothorax as a Poor Prognostic Indicator in COVID-19 in Turkey: A Propensity Score Matching Analysis"],"prefix":"10.4103","volume":"27","author":[{"given":"M","family":"\u00d6zgel","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Malatya Training Research Hospital, Malatya Turgut Ozal University Medical Faculty, Malatya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130","family":"G\u00fcl\u00e7ek","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Gaziantep City Hospital, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"A\u011far","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Elaz\u0131g Fethi Sekin City Hospital, Elaz\u0131g, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Uluta\u015f","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Medical Point Hospital, \u0130zmir Economy University, \u0130zmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,8,26]]},"reference":[{"key":"R1-20260427","doi-asserted-by":"crossref","first-page":"e20175","DOI":"10.1097\/MD.0000000000020175","article-title":"COVID-19 with cystic features on 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