{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:43:47Z","timestamp":1786653827689,"version":"build-2736575974"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/Aim:<\/jats:title>\n                    <jats:p>To evaluate red blood cell (RBC) transfusion practices in a pediatric intensive care unit (PICU) and identify factors predicting transfusion needs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective observational study was conducted on children (0\u201318 years) admitted to a tertiary academic PICU from January 2015 to December 2021. Demographic data, clinical parameters, and transfusion events were analyzed using Chi-square tests, logistic regression, and Kaplan-Meier estimation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 2,011 patients, 27.7% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 558) received at least one RBC transfusion, with a median pre-transfusion hemoglobin level of 8.9 g\/dL [IQR: 8.1\u20139.6]. Anemia was present in 47.59% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 957) at admission, with 48.17% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 461) requiring transfusion. Younger age (0\u20132 years: OR 2.22, 95% CI 1.9\u20132.61) and lower weight-for-age Z (WFA-Z) scores (severely underweight: OR 1.64, 95% CI 1.2\u20132.24) were associated with increased transfusion likelihood. Multiple transfusions were linked to higher mortality risk (OR 15.16, 95% CI 8.0\u201328.73,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Transfusion decisions in the PICU appeared to be influenced not only by hemoglobin values but also by age-related physiology, nutritional status, and baseline anemia. Anemia at discharge remained common, underscoring the need for structured post-discharge follow-up and prospective studies to refine individualized transfusion decision frameworks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_786_25","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:00:18Z","timestamp":1777572018000},"page":"401-408","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Patterns and Predictors of Red Blood Cell Transfusion in the Pediatric Intensive Care Unit: A Retrospective Cohort Study"],"prefix":"10.4103","volume":"29","author":[{"given":"IT","family":"Akbasli","sequence":"first","affiliation":[{"name":"Department of Pediatric Intensive Care Medicine, Hacettepe University, Ankara, Turkey"},{"name":"The Center for Life Support Practice and Research, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Kesici","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Medicine, Hacettepe University, Ankara, Turkey"},{"name":"The Center for Life Support Practice and Research, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Bayrakci","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Medicine, Hacettepe University, Ankara, Turkey"},{"name":"The Center for Life Support Practice and Research, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"R1-20260506","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1111\/trf.16520","article-title":"Neonatal and pediatric blood bank practice in the United States: Results from the AABB pediatric transfusion medicine subsection survey","volume":"61","author":"Reeves","year":"2021","journal-title":"Transfusion (Paris)"},{"key":"R3-20260506","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.athoracsur.2015.04.033","article-title":"Blood transfusions after pediatric cardiac operations: A north American multicenter prospective study","volume":"100","author":"Mazine","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"R4-20260506","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1164\/rccm.200711-1637OC","article-title":"Anemia, blood loss, and blood transfusions in North American children in the intensive care unit","volume":"178","author":"Bateman","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"R5-20260506","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/SHK.0000000000001863","article-title":"Outcomes associated with early RBC transfusion in pediatric severe sepsis: A propensity-adjusted multicenter cohort study","volume":"57","author":"Muszynski","year":"2022","journal-title":"Shock Augusta Ga"},{"key":"R7-20260506","first-page":"884","article-title":"Consensus recommendations for red blood cell transfusion practice in critically Ill children from the pediatric critical care transfusion and anemia expertise initiative","volume":"19","author":"Valentine","year":"2018","journal-title":"Pediatr Crit Care Med J Soc Crit Care Med World Fed Pediatr Intensive Crit Care Soc"},{"key":"R8-20260506","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1001\/jamainternmed.2017.5152","article-title":"Evidence-based guidelines to eliminate repetitive laboratory testing","volume":"177","author":"Eaton","year":"2017","journal-title":"JAMA Intern Med"},{"key":"R9-20260506","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13613-017-0328-8","article-title":"Anemia at pediatric intensive care unit discharge: Prevalence and risk markers","volume":"7","author":"Demaret","year":"2017","journal-title":"Ann Intensive Care"},{"key":"R10-20260506","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1001\/jama.2023.12914","article-title":"Red blood cell transfusion: 2023 AABB international guidelines","volume":"330","author":"Carson","year":"2023","journal-title":"JAMA"},{"key":"R11-20260506","article-title":"Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity","author":"Geneva","journal-title":"Vitamin and mineral nutrition information system. 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