{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:03:33Z","timestamp":1792598613061,"version":"4.5.0"},"reference-count":71,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Granulomatosis with polyangiitis (GPA) is rare but debilitating autoimmune disease and commonly presents with sinonasal as well as other head and neck symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To summarize the ear, nose, and throat-specific symptomatology and management of GPA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>We performed a literature review by using the PubMed search engine to provide a summary of recent and important literature that is pertinent to an otolaryngologist\u2019s clinical practice. We provide a guide on the pathophysiology, epidemiology, clinical features, investigation, and management (operative and nonoperative) of this important disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This review illustrates the important role that an otolaryngologist can play in the work up and symptom management of patients with GPA. Knowledge of the common presenting symptoms as well as more rare presentations of GPA is extremely important for otolaryngologists as prompt diagnosis and management is extremely important to avoid significant morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_790_23","type":"journal-article","created":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T13:00:23Z","timestamp":1722085223000},"page":"819-826","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Granulomatosis with Polyangiitis: A Rare but Clinically Important Disease for the Otolaryngologist"],"prefix":"10.4103","volume":"27","author":[{"given":"H","family":"Webb","sequence":"first","affiliation":[{"name":"Otolaryngology and Head and Neck Surgery, Austin Hospital, Heidelberg Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Toppi","sequence":"additional","affiliation":[{"name":"Otolaryngology and Head and Neck Surgery, Austin Hospital, Heidelberg Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Fairley","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The Alfred Hospital, Melbourne, Victoria, Australia"},{"name":"Department of Medicine, Dentistry and Health Sciences, The University of Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Phillips","sequence":"additional","affiliation":[{"name":"Otolaryngology and Head and Neck Surgery, Austin Hospital, Heidelberg Victoria, Australia"},{"name":"Otolaryngology and Head and Neck Surgery, Royal Children\u2019s Hospital, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,7,27]]},"reference":[{"key":"R1-20260507","doi-asserted-by":"crossref","first-page":"71.","DOI":"10.1038\/s41572-020-0204-y","article-title":"ANCA-associated vasculitis","volume":"6","author":"Kitching","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"R2-20260507","doi-asserted-by":"crossref","first-page":"m1070","DOI":"10.1136\/bmj.m1070","article-title":"ANCA associated vasculitis","volume":"369","author":"Hunter","year":"2020","journal-title":"BMJ"},{"key":"R3-20260507","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10157-013-0869-6","article-title":"Overview of the 2012 revised International Chapel Hill Consensus Conference nomenclature of vasculitides","volume":"17","author":"Jennette","year":"2013","journal-title":"Clin Exp Nephrol"},{"key":"R4-20260507","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1073\/pnas.87.11.4115","article-title":"Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro","volume":"87","author":"Falk","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R5-20260507","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s11926-012-0286-y","article-title":"Pathogenesis of ANCA-associated vasculitis","volume":"14","author":"Cartin-Ceba","year":"2012","journal-title":"Curr Rheumatol Rep"},{"key":"R6-20260507","first-page":"48","article-title":"Diagnosis and classification of granulomatosis with polyangiitis (aka Wegener\u2019s granulomatosis)","author":"Lutalo","year":"2014","journal-title":"J Autoimmun"},{"key":"R8-20260507","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/art.10830","article-title":"Are environmental factors important in primary systemic vasculitis? 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