{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:59:18Z","timestamp":1787169558218,"version":"build-2736575974"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>In patients with type 1 neurofibromatosis (NF1), there is an increased susceptibility to tumor development in the central nervous system due to the loss of neurofibromin, an inactivator of the protooncogene Ras. NF1 has a broad clinical spectrum,which includes spinal tumors. Although the most common intramedullary tumor of the spinal cord in adults is ependymoma, few patients with NF1 accompanied by spinal ependymoma have been reported to date, and the localization of the tumors is cervical and thoracic in these cases. In this study, we report the case of a patient with NF1 presenting to our clinic with low back pain and gait disturbance. The patient had an intradural extramedullary ependymoma at the L2-3 vertebra level. This report is the first case of NF1 with spinal ependymoma localized in the lumbar region.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_79_21","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T02:37:13Z","timestamp":1644979033000},"page":"197-199","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["A rare tumor case in an adult patient with neurofibromatosis"],"prefix":"10.4103","volume":"25","author":[{"given":"H","family":"Yakar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Ertu\u011frul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20240907","first-page":"131","article-title":"Neurocutaneous syndromes-phacomatoses","volume":"27","author":"Bulduk","year":"2017","journal-title":"T\u00fcrk N\u00f6ro\u015fir\u00fcrji Dergisi"},{"key":"R2-12-20240907","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/oxfordjournals.aje.a010118","article-title":"NF1 gene and neurofibromatosis 1","volume":"151","author":"Rasmussen","year":"2000","journal-title":"Am J Epidemiol"},{"key":"R3-12-20240907","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/NEN.0b013e318165eb75","article-title":"Gliomas in neurofibromatosis type 1: A riguez FJ, Perry A, Gutmann DH, O'Neill clinicopathologic study of 100 patients","volume":"67","author":"Rodriguez","year":"2008","journal-title":"J Neuropathol Exp Neurol"},{"key":"R4-12-20240907","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.wneu.2017.12.069","article-title":"Rare giant intradural extramedullary ependymoma","volume":"111","author":"Liao","year":"2018","journal-title":"World Neurosurg"},{"key":"R5-12-20240907","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S1470-2045(09)70033-6","article-title":"Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1","volume":"10","author":"Brems","year":"2009","journal-title":"Lancet Oncol"},{"key":"R6-12-20240907","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/(SICI)1098-1004(1997)9:5<458::AID-HUMU13>3.0.CO;2-1","article-title":"Deletions spanning the neurofibromatosis type 1 gene: Implications for genotype-phenotype correlations in neurofibromatosis type 1?","volume":"9","author":"Cnossen","year":"1997","journal-title":"Hum Mutat"},{"key":"R7-12-20240907","first-page":"183","article-title":"Tumors of the spinal cord. 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