{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:31:03Z","timestamp":1786739463065,"version":"build-2736575974"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effect of dental caries and oral health of patients on salivary cytokine levels with Hashimoto\u2019s thyroiditis (HT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>\n                      The study included 30 patients (n = 30) diagnosed with HT. The standardization of the participants was achieved with specific biochemical parameters, and the sociodemographic information of the patients was obtained through anamnesis. A pH meter was employed for salivary pH measurement. After determining the oral problems of the patients, necessary treatments were applied. Following 3 months of treatment, saliva samples were taken to evaluate cytokine levels (TNF-\u03b1, IL-6, IL-8, and CRP) and for ELISA analyses. The Wilcoxon test was used for pairwise comparison of nonparametric data, and the Chi-square test was employed to analyze categorical variables at\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There was a significant decrease in salivary TNF-\u03b1, IL-6, IL-8, and CRP levels between the measurements before and after 3 months of treatment (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). In addition, a significant increase was found in salivary pH (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The salivary cytokine levels decrease and the inflammatory response improves when the inflammation in the periodontal tissues and dental caries is treated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_820_22","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:42Z","timestamp":1707177642000},"page":"8-15","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["The Effect of Saliva and Dental Caries of the Patients with Hashimoto Thyroiditis on Cytokine Levels"],"prefix":"10.4103","volume":"27","author":[{"given":"A","family":"G\u00fcng\u00f6r Bors\u00f6ken","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry, Faculty of Dentistry, Gaziantep University, \u015eehitkamil, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Gursel Surmel\u0131oglu","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Faculty of Dentistry, Gaziantep University, \u015eehitkamil, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"R1-20260528","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/PAP.0b013e3182534868","article-title":"Hashimoto thyroiditis:A century later","volume":"19","author":"Ahmed","year":"2012","journal-title":"Adv Anat Pathol"},{"key":"R2-20260528","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.4317\/medoral.20559","article-title":"Evaluation of Xerostomia and salivary flow rate in Hashimoto's thyroiditis","volume":"21","author":"Agha-Hosseini","year":"2016","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"R3-20260528","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/iej.12030","article-title":"Cytokines as diagnostic markers of pulpal inflammation","volume":"46","author":"Elsalhy","year":"2013","journal-title":"Int Endod J"},{"key":"R4-20260528","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.joen.2014.12.021","article-title":"C-reactive protein expression is up-regulated in apical lesions of endodontic origin in association with interleukin-6","volume":"41","author":"Garrido","year":"2015","journal-title":"J Endod"},{"key":"R5-20260528","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/0090-1229(92)90042-M","article-title":"Interleukin-6 and its relation to inflammation and disease","volume":"62","author":"Hirano","year":"1992","journal-title":"J Clin Immunol Immunopathol"},{"key":"R6-20260528","first-page":"1207","article-title":"Mechanisms of pathogenesis in scleroderma. 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