{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:05:40Z","timestamp":1787169940632,"version":"build-2736575974"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To investigate the effect of intravitreal dexamethasone implant on central foveal thickness and choroidal thickness in retinal vein occlusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Clinical records and optical coherence tomography (OCT) scans of 41 na\u00efve patients with retinal vein occlusion (RVO), who were initially treated with intravitreal dexamethasone (DEX) implant between 2016 and 2017 at Kocatepe University Faculty of Medicine, Department of Ophthalmology were investigated. Collected data included age and sex of the patients, crystalline lens status, baseline and final intraocular pressure, and OCT parameters including central foveal thickness and choroidal thickness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Twenty-two (53.7%) female and 19 (46.3%) male patients were enrolled in the study. There were 30 phakic and 11 pseudophakic patients. The intraocular pressure increased significantly from 15.19 mmHg to 17.8 mmHg (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.005), and cataract extraction was performed in two patients who developed cataract after the treatment. There was a significant decrease in the central foveal thickness from 556 \u03bcm to 288 \u03bcm (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). In addition, although there was no statistically significant change in choroidal thickness in the patients with branched retinal vein occlusion (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.423), the patients with central retinal vein occlusion had statistically significant decrease in choroidal thickness measurements (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.049).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Therapeutic effect of the DEX implant not only influences retinal layer. Its influence may also extend further to the choroid layer, thereby leading to decrease in the choroidal thickness. Our results were mostly similar to the results of studies in literature which investigated the effects of the DEX implant therapy on the choroidal thickness of the patients with RVO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_87_20","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T02:48:05Z","timestamp":1692586085000},"page":"121-126","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["The Effect of Intravitreal Dexamethasone Implant on Central Foveal Thickness and Choroidal Thickness in Retinal Vein Occlusion"],"prefix":"10.4103","volume":"24","author":[{"given":"\u00d6","family":"Ero\u011ful","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Yozgat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MC","family":"Sabaner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Do\u011fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HH","family":"Gobeka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20-20240907","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.ophtha.2014.10.013","article-title":"Therapies for macular edema associated with central retinal vein occlusion: A report by the American Academy of Ophthalmology","volume":"122","author":"Yeh","year":"2015","journal-title":"Ophthalmology"},{"key":"R2-20-20240907","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ophtha.2009.07.017","article-title":"The prevalence of retinal vein occlusion: Pooled data from population studies from the United States, Europe, Asia, and Australia","volume":"117","author":"Rogers","year":"2010","journal-title":"Ophthalmology"},{"key":"R3-20-20240907","doi-asserted-by":"crossref","first-page":"5","DOI":"10.14744\/bej.65375","article-title":"Ranibizumab in macular edema secondary to retinal vein occlusion in a real life practice: A retrospective case series","volume":"1","author":"Ozkaya","year":"2016","journal-title":"Beyoglu Eye J"},{"key":"R4-20-20240907","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.2147\/OPTH.S144688","article-title":"Intravitreal bevacizumab injections versus dexamethasone implant for treatment-na\u00efve retinal vein occlusion related macular edema","volume":"11","author":"Laine","year":"2017","journal-title":"Clin Ophthalmol"},{"key":"R5-20-20240907","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.ophtha.2006.11.011","article-title":"Interventions for central retinal vein occlusion: An evidence-based systematic review","volume":"114","author":"Mohamed","year":"2007","journal-title":"Ophthalmology"},{"key":"R6-20-20240907","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ophtha.2008.10.017","article-title":"SCORE Study report 1: Baseline associations between central retinal thickness and visual acuity in patients with retinal vein occlusion","volume":"116","author":"Scott","year":"2009","journal-title":"Ophthalmology"},{"key":"R7-20-20240907","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.ophtha.2010.03.032","article-title":"Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion","volume":"117","author":"Haller","year":"2010","journal-title":"Ophthalmology"},{"key":"R8-20-20240907","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/j.ophtha.2012.05.017","article-title":"Improved vision-related function after ranibizumab for macular edema after retinal vein occlusion: Results from the BRAVO and CRUISE trials","volume":"119","author":"Varma","year":"2012","journal-title":"Ophthalmology"},{"key":"R9-20-20240907","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1001\/archophthalmol.2009.234","article-title":"A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with observation to treat vision loss associated with macular edema secondary to central retinal vein occlusion: The Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study report 5","volume":"127","author":"Ip","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"R10-20-20240907","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.ophtha.2014.01.027","article-title":"Intravitreal aflibercept injection for macular edema due to central retinal vein occlusion; two year results from the COPERNICUS study","volume":"121","author":"Heier","year":"2014","journal-title":"Ophthalmology"},{"key":"R11-20-20240907","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.ophtha.2010.02.022","article-title":"CRUISE investigators. 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