{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:17:24Z","timestamp":1787764644997,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>An accurate diagnosis and timely surgical intervention have significant importance in noncomplicated appendicitis (NCA) and complicated appendicitis (CA). Therefore, any factor that helps in the prediction of CA also contributes to suitable treatment options.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>This retrospective study aimed to identify any relationship between acute appendicitis (AA) and preoperative blood test levels and whether these parameters can differentiate between NCA and CA patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>A database of 201 appendectomies and 100 control healthy patients was analyzed between 2019 and 2022. Patients were divided into three groups: NCA without peritonitis or phlegmonous appendicitis as group 1; CA with perforated, necrotizing appendicitis with peritonitis as group 2; and the healthy control group (CG) as group 3. White blood cell (WBC), platelet distribution width (PDW), mean platelet volume (MPV), red cell distribution width (RDW), creatine kinase (CK), and bilirubin levels were collected from the patients and compared statistically between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Age, WBC, and PDW levels were set as predictive in the differential diagnosis of CA as a result of receiver operating characteristic (ROC) analysis. The multivariate analysis demonstrated that age (OR: 1.023; 95% CI: 1.000\u20131.045;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04), male sex (OR: 3.718; 95% CI: 1.501\u20139.213;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.005), WBC levels (OR: 1.000; 95% CI: 1.000\u20131.000;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002), and PDW levels (OR: 2.129; 95% CI: 1.301\u20133.484;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003) were independently associated with CA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Age, higher WBC count, and PDW levels are valuable in differentiating the diagnosis of CA from NCA, and this could be a feasible approach for surgical decisions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_906_22","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T01:22:26Z","timestamp":1690852946000},"page":"1005-1010","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["The Diagnostic Role of Preoperative Blood Tests in Complicated Appendicitis: A Feasible Approach to Surgical Decision"],"prefix":"10.4103","volume":"26","author":[{"given":"E","family":"Oymaci","sequence":"first","affiliation":[{"name":"Department of General Surgery, Health Sciences University, Izmir Bozyaka Education and Research Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Kahramansoy","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Health Sciences University, Izmir Bozyaka Education and Research Hospital, 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