{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:01:15Z","timestamp":1787169675206,"version":"build-2736575974"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Oxidative stress triggered by hyperglycemia in diabetic patients leads to macrovascular and microvascular complications, resulting in deterioration in the quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>This study aimed to compare the oxidative stress status and quality of life in participants with type 2 diabetes mellitus according to treatment modality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>Ninety type 2 diabetes mellitus participants aged between 40 and 60 years were included in the study. Forty-five participants were receiving oral antidiabetic drugs and 45 participants were receiving insulin therapy. Total antioxidant status, total oxidant status, and paraoxonase-1 were measured and oxidative stress indices were calculated. The SF-36 quality of life questionnaire was applied to the participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The total oxidant status and oxidative stress indices values were higher in the insulin-treated group than in the group treated with oral antidiabetic drugs. Paraoxonase-1 activities of the oral antidiabetic drugs-treated group were statistically significantly higher than the insulin-treated group. In the oral antidiabetic drugs-treated group, the physical function, social function, and pain subscale scores were higher than that of the insulin-treated group. In all participants, a negative correlation between total antioxidant status and fasting blood glucose and hemoglobin A1c, a positive correlation between total oxidant status and hemoglobin A1c and triglyceride, and a positive correlation was found between oxidative stress indices and fasting blood glucose and hemoglobin A1c.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>It was found that oxidative stress parameters were higher and quality of life was worse in the insulin-treated participants than participants treated with oral antidiabetic drugs. These results may be closely related to more severe chronic complications in insulin-dependent diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_92_20","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T02:37:13Z","timestamp":1644979033000},"page":"130-136","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of oxidative stress status and quality of life in participants with type 2 diabetes mellitus according to treatment modality"],"prefix":"10.4103","volume":"25","author":[{"given":"O","family":"Kuet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TP","family":"Kilit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Kocak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-2-20240907","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/S0026-0495(99)90152-X","article-title":"Depletion of total antioxidant capacity in type 2 diabetes","volume":"48","author":"Opara","year":"1999","journal-title":"Metabolism"},{"key":"R2-2-20240907","doi-asserted-by":"crossref","first-page":"F1144","DOI":"10.1152\/ajprenal.00221.2004","article-title":"NAD (P) H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy","volume":"288","author":"Satoh","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"R3-2-20240907","doi-asserted-by":"crossref","first-page":"e0170003","DOI":"10.1371\/journal.pone.0170003","article-title":"Significance of serum total oxidant\/antioxidant status in patients with colorectal cancer","volume":"12","author":"Wu","year":"2017","journal-title":"PLoS One"},{"key":"R4-2-20240907","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1042\/CS20040187","article-title":"Genetic and environmental factors modulating serum concentrations and activities of the antioxidant enzyme paraoxonase-1","volume":"107","author":"Deakin","year":"2004","journal-title":"Clin Sci (Lond"},{"key":"R5-2-20240907","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1161\/01.ATV.17.6.1067","article-title":"Genetic polymorphism of paraoxonase and the risk of coronary heart disease","volume":"17","author":"Sanghera","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R6-2-20240907","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/da.20288","article-title":"The effect of depression on quality of life of patients with type II diabetes mellitus","volume":"25","author":"Eren","year":"2008","journal-title":"Depress Anxiety"},{"key":"R7-2-20240907","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/(SICI)1096-9136(199604)13:4<382::AID-DIA14>3.0.CO;2-Y","article-title":"Health related quality of life in diabetic patients measured by the Nottingham Health Profile","volume":"13","author":"Keinanen-Kiukaanniemi","year":"1996","journal-title":"Diabet Med"},{"key":"R8-2-20240907","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/pubmed\/21.3.255","article-title":"Short Form 36 (SF-36) Health survey questionnaire: Which normative data should be used? 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