{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:36:06Z","timestamp":1786649766174,"version":"build-2736575974"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acute appendicitis (AA) is the most common cause of acute abdomen. In addition to clinical evaluation, laboratory and imaging methods are widely used in diagnosis. The neutrophil-to-lymphocyte ratio (NLR) is an easily accessible biomarker of inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>This study aimed to investigate the relationship between NLR and computed tomography (CT) findings in patients with AA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective study analyzed cases of acute appendicitis diagnosed between February 2018 and July 2023. Demographic characteristics, laboratory values, and CT findings were evaluated. Statistical analyses included correlation tests, logistic regression, and ROC curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of the 159 patients, 66 (41.5%) were female and 93 (58.5%) male, with a median age of 34. The mean appendiceal diameter was 10 mm. Other CT findings included periappendiceal fat stranding (97.5%), lymphadenopathy (85.5%), free fluid (34.6%), and abscess formation (5.7%). In patients with free fluid, HGB and HCT levels were significantly lower, while WBC, neutrophils, PLT, NLR, and platelet-to-lymphocyte ratio (PLR) were higher (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). ROC analysis identified an optimal NLR cut-off value of 4.45 for predicting free fluid, with 70.9% sensitivity and 63.5% specificity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>NLR shows a significant correlation with CT findings in AA and may help predict disease severity. Particularly in centers with limited CT access, NLR may be considered a complementary parameter alongside clinical evaluation and imaging methods.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njcp.njcp_95_25","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:00:22Z","timestamp":1774926022000},"page":"273-279","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Correlation Between NLR and Abdominal CT and Its Predictive Value in Patients with Acute Appendicitis"],"prefix":"10.4103","volume":"29","author":[{"given":"K","family":"G\u00f6k\u00e7e","sequence":"first","affiliation":[{"name":"Department of General Surgery, Surgical Oncology Unit, School of Medicine, Okan University, \u0130stanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine, Okan University, \u0130stanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"R1-20260416","first-page":"79","article-title":"Diagnostic value of combination of neutrophyl to lymphocyte ratio with \u0131maging methods in the acute apendicitis","volume":"51","author":"Canpolat","year":"2018","journal-title":"Med J Ankara Tr Res Hosp"},{"key":"R2-20260416","first-page":"248","article-title":"[Ultrasonographic findings and evaluation of white blood cell counts in patients undergoing laparotomy with the diagnosis of acute appendicitis]","volume":"16","author":"Demircan","year":"2010","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"R3-20260416","doi-asserted-by":"crossref","first-page":"123","DOI":"10.12956\/tchd.674851","article-title":"Acute appendicitis in children; Assessment of diagnostic reliability of ultrasonography","volume":"15","author":"Gezer","year":"2021","journal-title":"Turk J Pediatr Dis"},{"key":"R4-20260416","doi-asserted-by":"crossref","first-page":"406","DOI":"10.2214\/ajr.185.2.01850406","article-title":"CT evaluation of appendicitis and its complications: Imaging techniques and key diagnostic findings","volume":"185","author":"Pinto Leite","year":"2005","journal-title":"AJR Am J Roentgenol"},{"key":"R5-20260416","first-page":"17","article-title":"Computed tomography \u0131n differential diagnosis of abdominal pain among patients with suspected acute appendicitis","volume":"2","author":"Arslan","year":"2019","journal-title":"Anatolian J Emerg Med"},{"key":"R6-20260416","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5505\/tjtes.2014.20688","article-title":"Neutrophil-to-lymphocyte ratio as a predictor of acute appendicitis","volume":"20","author":"Kahramanca","year":"2014","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"R7-20260416","doi-asserted-by":"crossref","first-page":"423","DOI":"10.5505\/tjtes.2014.75044","article-title":"The clinical value of leucocyte count and neutrophil percentage in diagnosing uncomplicated (simple) appendicitis and predicting complicated appendicitis","volume":"20","author":"\u015eahbaz","year":"2014","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"R8-20260416","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.3390\/diagnostics14242777","article-title":"The \u0131mportance of the neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) as biomarkers for differentiating complicated and uncomplicated appendicitis","volume":"14","author":"Anastasakis","year":"2024","journal-title":"Diagnostics (Basel)"},{"key":"R9-20260416","first-page":"45","article-title":"Can the neutrophil\/lymphocyte platelet ratio predict acute appendicitis? 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