{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:37:00Z","timestamp":1786649820581,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>Osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaws (MRONJ) are debilitating complications that compromise bone repair in patients, who have undergone radiotherapy or treatment with anti-resorptive\/anti-angiogenic drugs. Once established, these lesions are difficult to manage and reduce patients\u2019 quality of life. The combination of low- and high-power lasers, through photo biomodulation therapy and antimicrobial photodynamic therapy preceding surgical laser debridement, can provide satisfactory results in the treatment of these patients. Thus, the purpose of this work is to describe three cases associating these therapies for the management and treatment of ORN and ONMRM, offering an alternative, safe and effective therapy for these conditions.<\/jats:p>","DOI":"10.4103\/njms.njms_157_24","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T09:00:28Z","timestamp":1766739628000},"page":"576-580","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Use of antimicrobial photodynamic therapy and high-power Er:YAG laser in the treatment of drug- or radiation-induced bone necrosis: Case series"],"prefix":"10.4103","volume":"16","author":[{"given":"Larissa C.","family":"de Freitas","sequence":"first","affiliation":[{"name":"Department of Biomaterials and Oral Biology, School of Dentistry, University of S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabianne S.","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Oral Biology, School of Dentistry, University of S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciane H.","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Special Laboratory of Lasers in Dentistry, School of Dentistry, University of S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyne","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Oral Biology, School of Dentistry, University of S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"},{"name":"Special Laboratory of Lasers in Dentistry, School of Dentistry, University of S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,25]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1080\/0284186X.2019.1643037","article-title":"Osteoradionecrosis of the mandible after radiotherapy for head and neck cancer: Risk factors and dose-volume correlations","volume":"58","author":"Aarup-Kristensen","year":"2019","journal-title":"Acta Oncol"},{"key":"R2-20260420","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American association of oral and maxillofacial surgeons position paper on medication-related osteonecrosis of the jaw\u2013 2014 update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"key":"R3-20260420","doi-asserted-by":"crossref","first-page":"e20170172","DOI":"10.1590\/1678-7757-2017-0172","article-title":"Osteoradionecrosis of the jaws: Case series treated with adjuvant low-level laser therapy and antimicrobial photodynamic therapy","volume":"26","author":"Ribeiro","year":"2018","journal-title":"J Appl Oral Sci"},{"key":"R4-20260420","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.34172\/jlms.2023.58","article-title":"Use of phototherapy and Er-YAG Laser in the management of mandible osteoradionecrosis: A case report","volume":"14","author":"de Freitas","year":"2023","journal-title":"J Lasers Med Sci"},{"key":"R7-20260420","doi-asserted-by":"crossref","first-page":"e276","DOI":"10.1016\/j.bjoms.2020.07.031","article-title":"Preoperative status and treatment of osteoradionecrosis of the jaw: A retrospective study of 252 cases","volume":"58","author":"Jin","year":"2020","journal-title":"Br J Oral Maxillofac Surg"},{"key":"R8-20260420","first-page":"664","article-title":"Prevention and treatment of oral adverse effects of antiresorptive medications for osteoporosis \u2013 A position paper of the Brazilian society of endocrinology and metabolism (SBEM), Brazilian society of stomatology and oral pathology (Sobep), and brazilian association for bone evaluation and osteometabolism (Abrasso)","volume":"6","author":"Madeira","year":"2020","journal-title":"Arch Endocrinol Metab"},{"key":"R9-20260420","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1089\/pho.2004.22.342","article-title":"Histological and TEM examination of early stages of bone healing after Er:YAG laser irradiation","volume":"22","author":"Pourzarandian","year":"2004","journal-title":"Photomed Laser Surg"},{"key":"R10-20260420","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1089\/pho.2013.3493","article-title":"Lasers in dentistry: Overview and perspectives","volume":"31","author":"Dostalova","year":"2013","journal-title":"Photomed Laser Surg"},{"key":"R11-20260420","doi-asserted-by":"crossref","first-page":"e195","DOI":"10.4317\/medoral.24132","article-title":"Therapeutic alternatives in the management of osteoradionecrosis of the jaws. Systematic review","volume":"26","author":"Camolesi","year":"2021","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"R12-20260420","doi-asserted-by":"crossref","first-page":"101959","DOI":"10.1016\/j.pdpdt.2020.101959","article-title":"Photobiomodulation and antimicrobial photodynamic therapy as adjunct in the treatment and prevention of osteoradionecrosis of the jaws: A case report","volume":"31","author":"Magalh\u00e3es","year":"2020","journal-title":"Photodiagnosis Photodyn Ther"}],"container-title":["National Journal of Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/njms.njms_157_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:58:48Z","timestamp":1786647528000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/njms.njms_157_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/njms.njms_157_24","relation":{},"ISSN":["0975-5950","2229-3418"],"issn-type":[{"value":"0975-5950","type":"print"},{"value":"2229-3418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2024-10-14","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}