{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:26:23Z","timestamp":1787757983801,"version":"build-2784847793"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Both cleft lip and palate are among the most common birth defects, significantly impacting individuals and families socially, financially, and psychologically. Understanding the prevalence and patterns of these anomalies is essential for developing targeted healthcare interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>This study aimed to estimate the prevalence and analyze the patterns of cleft lip and\/or palate defects among patients referred to King Khalid General Hospital in Hafer Al-Baten, Saudi Arabia. The findings can help in formulating regional healthcare strategies and guiding policy decisions for better management of cleft cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective study was conducted in the Department of Oral Maxillofacial Surgery at King Khalid General Hospital, Hafer Al-Baten. Data of cleft lip and\/or palate patients from January 2014 to December 2022 were analyzed. Pearson Chi-square test was used to examine the distribution of cleft cases by year, gender, and side of the cleft.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The prevalence of cleft lip with or without cleft palate was 0.415 per 1000 live births. Males constituted 56.0% of cases, and females constituted 44.0%, with a mean age of 4.5 (\u00b11.6) months at diagnosis. One-third (33.1%) of cases had cleft palate only, while cleft lip was more common on the left side. Associated congenital anomalies, particularly cardiac diseases, were found in 1.2% of cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Orofacial clefts were more prevalent in males, with left-sided clefts being dominant. The study highlights the necessity of establishing a national registry for cleft anomalies in Saudi Arabia to improve healthcare planning. Further research is required to explore the genetic and environmental risk factors contributing to cleft development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njms.njms_158_24","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:00:23Z","timestamp":1780491623000},"page":"226-231","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and patterns of cleft lip and palate in Eastern Province of Saudi Arabia: A nine-year retrospective study"],"prefix":"10.4103","volume":"17","author":[{"given":"Zidan Muead","family":"Alanazi","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Central Hospital, Hafar Al Batin, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Salman","family":"Chishty","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Central Hospital, Hafar Al Batin, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Dhaher","family":"Alshammari","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Azizia Dental Center, Hafar Al Batin, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Saad","family":"Alqarni","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jouf University, Sakaka, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Adil","family":"Asim","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Diagnostic Sciences Faculty of Dentistry, Najran University, Najran, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Nadeem","family":"Baig","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, College of Dentistry, Jouf University, Sakaka, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaliputra","family":"Magar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jouf University, Sakaka, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakhi","family":"Issrani","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, College of Dentistry, Jouf University, Sakaka, Kingdom of Saudi Arabia"},{"name":"Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namdeo","family":"Prabhu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jouf University, Sakaka, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"R1-20260604","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1597\/12-135","article-title":"Prevalence of orofacial clefts in Nigeria","volume":"51","author":"Butali","year":"2014","journal-title":"Cleft Palate Craniofac J"},{"key":"R2-20260604","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1055\/s-0031-1277720","article-title":"Surgery for cleft palate and velopharyngeal dysfunction","volume":"32","author":"Pearson","year":"2011","journal-title":"Semin Speech Lang"},{"key":"R3-20260604","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1597\/15-221","article-title":"Systematic review and meta-analysis of the birth prevalence of orofacial clefts in low- and middle-income countries","volume":"54","author":"Kadir","year":"2017","journal-title":"Cleft Palate Craniofac J"},{"key":"R4-20260604","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.15537\/smj.2015.9.11823","article-title":"Birth prevalence of non-syndromic orofacial clefts in Saudi Arabia and the effects of parental consanguinity","volume":"36","author":"Sabbagh","year":"2015","journal-title":"Saudi Med J"},{"key":"R5-20260604","first-page":"95","article-title":"A review of classification systems for cleft lip and palate patients- I. 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