{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:35:17Z","timestamp":1787841317697,"version":"build-2784847793"},"reference-count":72,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>\n                    Human oral cavity is home to a number of organisms,\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    being one of them. This review article aims at understanding the correlation between the oral candidal colonization and the local host factors that may influence it with special emphasis on congenital craniofacial anomalies such as cleft lip and palate (CLP). Various scientific databases were searched online and relevant articles were selected based on the inclusion criteria. A comparative study was done to understand the interdependence of various factors (including CLP) and oral candidal colonization. The results revealed a strong association of certain local host factors which may influence the oral colonization of\n                    <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                    species. Factors such as mucosal barrier, salivary constituents and quantity of saliva, congenital deformities like CLP, oral prostheses such as dentures\/palatal obturators and fixed orthodontic appliances (FOAs) were identified. All these factors may directly affect the growth of\n                    <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                    in the oral cavity. Although numerous studies have pointed a positive correlation between Oral Candidal colonization and local host factors such as oral prostheses, FOA, and oral mucosal barrier only one study has been done, in the Indian subcontinent with respect to the correlation of candidal colonization and CLP. After the evaluation of all the factors mentioned in various case studies, it can be concluded that the presence of local host factors such as orofacial clefts, dental prostheses, FOA, xerostomia, and atrophy of the oral mucous membrane lead to significant increase in candidal colonization, but since very few studies in regard to CLP have been done worldwide and in India, in particular, further studies are warranted.\n                  <\/jats:p>","DOI":"10.4103\/njms.njms_161_20","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T08:40:48Z","timestamp":1608194448000},"page":"169-175","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Evaluating the role of local host factors in the candidal colonization of oral cavity: A review update"],"prefix":"10.4103","volume":"11","author":[{"given":"Imran","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India"},{"name":"Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanveer","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi, India"},{"name":"Department of Human Anatomy, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhat","family":"Manzoor","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshahid Alam","family":"Rizvi","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uqba","family":"Raza","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubhangi","family":"Premchandani","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,12,16]]},"reference":[{"key":"R1-20250920","doi-asserted-by":"crossref","first-page":"122","DOI":"10.4103\/jomfp.JOMFP_304_18","article-title":"Oral microbiome: Unveiling the fundamentals","volume":"23","author":"Deo","year":"2019","journal-title":"J Oral Maxillofac Pathol"},{"key":"R2-20250920","first-page":"291","article-title":"Acquisition and maturation of oral microbiome throughout childhood: An update","volume":"11","author":"Sampaio-Maia","year":"2014","journal-title":"Dent Res J (Isfahan)"},{"key":"R3-20250920","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.4103\/0973-029X.141325","article-title":"Oral candidiasis: An overview","volume":"18","author":"Singh","year":"2014","journal-title":"J Oral Maxillofac Pathol"},{"key":"R4-20250920","first-page":"487921","article-title":"Isolation and identification of Candida from the oral cavity","volume":"2011","author":"Byadarahally Raju","year":"2011","journal-title":"ISRN Dent"},{"key":"R5-20250920","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12903-019-0775-8","article-title":"Oral Candidal carriage and associated risk indicators among adults in Sakaka, Saudi Arabia","volume":"19","author":"Alrayyes","year":"2019","journal-title":"BMC Oral Health"},{"key":"R6-20250920","first-page":"1","year":"2016","journal-title":"Cleft Lip and Palate Anomaly in India: Clinical Profile, Risk Factors and Current Status of Treatment: A Hospital Based Study"},{"key":"R7-20250920","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4103\/0970-0358.57182","article-title":"Addressing the challenges of cleft lip and palate research in India","volume":"42","author":"Mossey","year":"2009","journal-title":"Indian J Plastic Surg"},{"key":"R8-20250920","first-page":"1, 18","article-title":"Host factors affecting oral candidiasis","volume":"26","author":"van Wyk","year":"2011","journal-title":"Southern Afr J Epidemiol Infect"},{"key":"R9-20250920","first-page":"1","article-title":"What makes oral candidiasis recurrent infection. 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