{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:21:58Z","timestamp":1787764918424,"version":"build-2784847793"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>Bone metabolism is a key factor for successful osseointegration, and low vitamin D levels may negatively impact the process of osseointegration after implant placement. The study was aimed at evaluating the relation of vitamin D levels with dental implant osseointegration and subsequently the success or failure of the implant. The focused questions were\u2014What is the effect of vitamin D levels on successful dental implant osseointegration and what is the effect of vitamin D supplementation on successful implant osseointegration? A search was conducted on PubMed and Google Scholar using the terms \u201cvitamin D,\u201d \u201ccholecalciferol,\u201d \u201c1,25(OH) D,\u201d \u201cdental implant,\u201d \u201cosseointegration,\u201d and \u201cbone implant contact\u201d for a period of 10 years from 2011 to 2020. Clinical trials, cross-sectional studies, case series, and case reports were included. A total of ten studies were included after the screening process. Five of these studies evaluated the effect of vitamin D supplementation on osseointegration, whereas five only evaluated the effect of vitamin D deficiency on dental implant osseointegration. Only five of these studies reported dental implant failure varying from 7% to 13% in vitamin D deficient\/insufficient groups. Positive relationship exists between serum vitamin D levels and dental implant osseointegration; however, few studies failed to report any relation. More prospective clinical research studies as well as randomized controlled trials are needed to show a significant correlation between decreased serum levels of vitamin D and increased risk of dental implant failure in perspective of vitamin D supplementation which can promote the osseointegration of dental implants.<\/jats:p>","DOI":"10.4103\/njms.njms_192_22","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T14:21:40Z","timestamp":1699626100000},"page":"360-368","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Significance of 25(OH) D3 in Early Dental Implant Failure (EDIF) during osseointegration\u2014A systematic review"],"prefix":"10.4103","volume":"14","author":[{"given":"Anshdha","family":"Shah","sequence":"first","affiliation":[{"name":"Scientist B, UCMS and GTB Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalpana","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, King George's Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitendra","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, King George's Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhawna","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, ESIC Dental College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaidem Deba","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Dental College JNIMS, Imphal, Manipur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"key":"R1-20260512","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2174\/1874210601408010050","article-title":"A Brief historical perspective on dental implants, their surface coatings and treatments","volume":"8","author":"Abraham","year":"2014","journal-title":"Open Dent J"},{"key":"R2-20260512","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3109\/17453678709146401","article-title":"Osseointegration of bone implants: A review of an alternative mode of fixation","volume":"58","author":"Albrektsson","year":"1987","journal-title":"Acta Orthop Scand"},{"key":"R3-20260512","doi-asserted-by":"crossref","first-page":"50","DOI":"10.5125\/jkaoms.2014.40.2.50","article-title":"Current trends in dental implants","volume":"40","author":"Gaviria","year":"2014","journal-title":"J Korean Assoc Oral Maxillofac Surg"},{"key":"R4-20260512","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/ID.0b013e3180de4ec5","article-title":"Immediate implant loading: Current status from available literature","volume":"16","author":"Avila","year":"2007","journal-title":"Implant Dent"},{"key":"R5-20260512","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1600-0757.2008.00267.x","article-title":"Implant stability measurements using resonance frequency analysis: Biological aspects and clinical implications","volume":"47","author":"Sennerby","year":"2008","journal-title":"Periodontol 2000"},{"issue":"Suppl 1","key":"R6-20260512","first-page":"S93","article-title":"Oral implant survival in patients with bisphosphonate (BP)\/antiresorptive and radiation therapy and their impact on osteonecrosis of the jaws. 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