{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:50:36Z","timestamp":1789156236125,"version":"build-2803163510"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Oral lichen planus is a common, chronic mucocutaneous condition of uncertain origin. Early treatment of OLP can dramatically reduce the risk of further development, which in turn reduces the risk of developing cancer. Numerous methods can be used to treat OLP. Since the significance of ozone in treating this disease is still uncertain. This systematic review was conducted based on english databases, including PUBMED, SCOPUS, Embase, Ovid, and Journal of Web up to July 2022. We used the search phrases \u201cozone,\u201d \u201cozone in the treatment of oral lichen planus,\u201d \u201coral lichen planus,\u201d and \u201cozone therapy.\u201d Finally, five papers were selected for qualitative analysis. This review included a total of five papers, four of which were clinical trials and one was a longitudinal study. All studies included the erosive form of OLP, also ozone therapy was applied to patients who did not respond to conventional treatment. Ozone showed significant therapeutic effects in terms of reduction in pain and size of the lesion. The signs and symptoms associated with OLP such as burning sensation, lesion size, and scarring all considerably improved with ozone therapy.<\/jats:p>","DOI":"10.4103\/njms.njms_20_23","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T11:00:09Z","timestamp":1710932409000},"page":"18-22","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Evidence-based effectiveness of Ozone therapy in the treatment for oral lichen planus \u2013 A systematic review"],"prefix":"10.4103","volume":"15","author":[{"given":"Ajay","family":"Kumar","sequence":"first","affiliation":[{"name":"Unit of Oral Medicine and Radiology, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adit","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Unit of Oral Medicine and Radiology, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Sah","sequence":"additional","affiliation":[{"name":"Unit of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonam","family":"Sah","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Teerthanker Mahaveer Dental College and Research Centre, Muradabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinayalekshmy I. N.","family":"Nair","sequence":"additional","affiliation":[{"name":"Unit of Oral Medicine and Radiology, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Dental College Azamgarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhilesh Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Unit of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"issue":"(Suppl 1)","key":"R1-20240908","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.4103\/0973-029X.141322","article-title":"Oral potentially malignant disorders:A proposal for terminology and definition with review of literature","volume":"18","author":"Sarode","year":"2014","journal-title":"J Oral Maxillofac Pathol"},{"key":"R2-20240908","first-page":"577","article-title":"Oral lichen planus;A case repot","volume":"5","author":"Ahmed","journal-title":"Int J Adv Res"},{"key":"R3-20240908","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1054\/bjom.2000.0335","article-title":"Oral lichen planus:A review","volume":"38","author":"Mollaoglu","year":"2000","journal-title":"Br J Oral Maxillofac Surg"},{"key":"R5-20240908","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.2174\/1389557519666190301144157","article-title":"Clinical management of oral lichen planus:A systematic review","volume":"19","author":"Oberti","year":"2019","journal-title":"Mini Rev Med Chem"},{"key":"R6-20240908","first-page":"102","article-title":"Role of ozone therapy in minimal intervention dentistry and endodontics-a review","volume":"5","author":"A","year":"2013","journal-title":"J Int Oral Health"},{"key":"R7-20240908","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses:The PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"R8-20240908","first-page":"e675","article-title":"Efficacy of ozonized water for the treatment of erosive oral lichen planus:A randomized controlled study","volume":"25","author":"Veneri","year":"2020","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"R9-20240908","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3889\/oamjms.2018.219","article-title":"Evaluation of combined topical ozone and steroid therapy in management of oral lichen planus","volume":"6","author":"Mostafa","year":"2018","journal-title":"Open Access Maced J Med Sci"},{"key":"R10-20240908","first-page":"240","article-title":"Evaluation of the efficacy of ozone gas therapy against conventional topical corticosteroids for the management of oral reticular lichen planus","volume":"4","author":"Shete","year":"2017","journal-title":"ejbps"},{"key":"R11-20240908","doi-asserted-by":"crossref","first-page":"485","DOI":"10.5021\/ad.2015.27.5.485","article-title":"Comparison of low-level laser therapy versus ozone therapy in the treatment of oral lichen planus","volume":"27","author":"Kazancioglu","year":"2015","journal-title":"Ann Dermatol"},{"key":"R12-20240908","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4103\/0976-237X.177097","article-title":"Efficacy of ozonized olive oil in the management of oral lesions and conditions:A clinical trial","volume":"7","author":"Kumar","year":"2016","journal-title":"Contemp Clin Dent"},{"key":"R13-20240908","doi-asserted-by":"crossref","first-page":"5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration's tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"R15-20240908","first-page":"97","article-title":"The clinical application of ozonetherapy","author":"Bocci","year":"2020","journal-title":"OZONE, Springer, Dordrecht"},{"key":"R16-20240908","first-page":"73","article-title":"Role of immunomodulators in oral diseases","volume":"2","author":"Shivhare","year":"2015","journal-title":"Int J Oral Health Med Res"},{"key":"R17-20240908","doi-asserted-by":"crossref","first-page":"7890","DOI":"10.3390\/ijms22157890","article-title":"Ozone in Medicine. The low-dose ozone concept and its basic biochemical mechanisms of action in chronic inflammatory diseases","volume":"22","author":"Viebahn-Haensler","year":"2021","journal-title":"Int J Mol Sci"},{"key":"R18-20240908","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/odi.12634","article-title":"Interventions for the management of oral lichen planus:A review of the conventional and novel therapies","volume":"23","author":"Gupta","year":"2017","journal-title":"Oral Dis"},{"key":"R19-20240908","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4103\/njms.njms_504_21","article-title":"Platelet-rich plasma protein as a therapeutic regimen for oral lichen planus:An evidence-based systematic review","volume":"14","author":"Maddheshiya","year":"2023","journal-title":"Natl J Maxillofac Surg"}],"container-title":["National Journal of Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/njms.njms_20_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:28:03Z","timestamp":1787768883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/njms.njms_20_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/njms.njms_20_23","relation":{},"ISSN":["0975-5950","2229-3418"],"issn-type":[{"value":"0975-5950","type":"print"},{"value":"2229-3418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-01-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}