{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:00:00Z","timestamp":1787169600951,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Medical management of oral submucous fibrosis which is a common precancerous condition affecting population of Asian descent is still under investigations. Various modalities of medical management are detailed in the literature with varying degree of success. The major aim of the study is to evaluate the outcomes of platelet rich plasma and stem cells in the medical management of oral sub mucous fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Ten patients diagnosed with stage II, III and IV oral submucous fibrosis were included in the study. The stem cells and PRP derived from patients peripheral blood were injected intraorally into the areas of fibrosis. Mouth opening were recorded at the follow up visits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>All patients showed satisfactory results at the end of 6 months follow up interval. Mouth opening has improved post treatment; however we suggest a long term study with more number of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Stem cells and PRP can be a new effective modality for medical management of oral submucous fibrosis which requires detailed scientific studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/njms.njms_219_22","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:01:00Z","timestamp":1780491660000},"page":"256-260","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of stem cells and platelet rich plasma in the treatment of oral submucous fibrosis"],"prefix":"10.4103","volume":"17","author":[{"given":"Sushmit Priyam","family":"Bora","sequence":"first","affiliation":[{"name":"Department of Dentistry, Assam Medical College and Hospital, Dibrugarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyajit","family":"Dandagi","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Assam Medical College and Hospital, Dibrugarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bheemappa","family":"Bangennavar","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Assam Medical College and Hospital, Dibrugarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Jose","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital of the West Indies, Kingston, Jamaica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunny Sinh","family":"Digwa","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, ECHS Polyclinic, Kolhapur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. R. Ragini","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, SJM Institute of Dental Sciences, Chitradurga, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"R1-20260604","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/0278-2391(88)90043-2","article-title":"Oral submucous fibrosis-A new treatment regimen","volume":"46","author":"Gupta","year":"1988","journal-title":"J Oral Maxillofac Surg"},{"key":"R2-20260604","first-page":"21","article-title":"Novel approach in the management of an oral premalignant condition \u2013A case report","volume":"3","author":"Sankaranarayanan","year":"2007","journal-title":"J Stem Cells Regen Med"},{"key":"R3-20260604","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1902\/jop.2007.060302","article-title":"Platelet rich plasma: Growth factors and pro- and anti-inflammatory properties","volume":"78","author":"El-Sharkawy","year":"2007","journal-title":"J Periodontol"},{"key":"R4-20260604","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1600-065X.2007.00565.x","article-title":"\u2018Yin-Yang\u2019 functions of transforming growth factor-beta and T regulatory cells in immune regulation","volume":"220","author":"Wan","year":"2007","journal-title":"Immunol Rev"},{"key":"R5-20260604","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1089\/ten.teb.2008.0062","article-title":"The biology of platelet-rich plasma and its application in oral surgery: Literature review","volume":"14","author":"Nikolidakis","year":"2008","journal-title":"Tissue Eng B"},{"key":"R6-20260604","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00266-007-9022-9","article-title":"Autologous plateletrich plasma as an adipocyte in vivo delivery system: Case report","volume":"32","author":"Azzena","year":"2008","journal-title":"Aesthetic Plast Surg"},{"key":"R7-20260604","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0901-5027(05)80473-4","article-title":"Oral submucous fibrosis-A new concept in surgical management","volume":"24","author":"Khanna","year":"1995","journal-title":"Int J Oral Maxillofac Surg"},{"key":"R8-20260604","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1532-950X.2005.00063.x","article-title":"Stem cells, classifications, controversies and clinical applications","volume":"34","author":"Fortier","year":"2005","journal-title":"Vet Surg"},{"key":"R9-20260604","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1475-2867-7-9","article-title":"Role of stem cells in cancer therapy and cancer stem cells: A review","volume":"7","author":"Sagar","year":"2007","journal-title":"Cancer Cell Int"},{"key":"R10-20260604","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1160\/TH03-07-0440","article-title":"Autologous platelets as source of proteins for healing and tissue regeneration","volume":"91","author":"Anitua","year":"2004","journal-title":"Thromb Haemost"},{"key":"R11-20260604","first-page":"43880","article-title":"\u201cRole of stem cell therapy in oral premalignat and malignant lesions\u201d","volume":"8","author":"Adalja","year":"2016","journal-title":"Int J Curr Res"},{"key":"R12-20260604","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5005\/jp-journals-10011-1329","article-title":"Autologous bone marrow concentrate (Mononuclear Stem Cell) therapy in the treatment of oral submucous fibrosis","volume":"25","author":"Seshadri","year":"2013","journal-title":"J Indian Acad Oral Med Radiol"}],"container-title":["National Journal of Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/njms.njms_219_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:10:30Z","timestamp":1787166630000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/njms.njms_219_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/njms.njms_219_22","relation":{},"ISSN":["0975-5950","2229-3418"],"issn-type":[{"value":"0975-5950","type":"print"},{"value":"2229-3418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2022-12-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}