{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:36:23Z","timestamp":1787070983204,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:p>Central giant cell lesion (CGCL) is a benign intraosseous lesion that usually accompany the gnathic bones in the anterior region, mostly crossing the midline. Its clinical features involve cortical expansion, tooth displacement, and root resorption. Pain may occur in 20% of cases. Histopathological characteristics are like other pathological entities, being necessary discarding them. In this case, a 53-year-old female presented an expansive legion in the anterior mandible with tooth displacement and pain. After incisional biopsy, the result was CGCL. Surgical planning involved manufacturing a biomodel, bending the reconstruction plate to give the correct mandibular arch perimeter. After that, it was performed a segmental resection and installation of a reconstruction plate using a cervical approach. The patient is under follow-up with no signs of recurrence or complications.<\/jats:p>","DOI":"10.4103\/njms.njms_227_20","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T02:35:41Z","timestamp":1639449341000},"page":"414-417","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Treatment of a central giant cell lesion in the mandible"],"prefix":"10.4103","volume":"12","author":[{"given":"BERNARDO CORREIA","family":"LIMA","sequence":"first","affiliation":[{"name":"Department of Oral Surgery, Oral Surgery Service, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GIULIANNA LIMA","family":"PINHEIRO","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Oral Surgery Service, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LEONARDO AUGUSTUS PERAL FERREIRA","family":"PINTO","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Oral Surgery Service, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIA APARECIDA DE ALBUQUERQUE","family":"CAVALCANTE","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Oral Surgery Service, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"key":"R1-20250925","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40463-019-0356-5","article-title":"An aggressive central giant cell granuloma in a pediatric patient: Case report and review of literature","volume":"48","author":"Wang","year":"2019","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"R2-20250925","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0030-4220(53)90151-0","article-title":"Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-oseous) dysplasia of the jawbones","volume":"6","author":"Jaffe","year":"1953","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"R3-20250925","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/0278-2391(86)90040-6","article-title":"Central giant cell lesions of the jaws: A clinicopathologic study","volume":"44","author":"Chuong","year":"1986","journal-title":"J Oral Maxillofac Surg"},{"key":"R4-20250925","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jcms.2009.04.002","article-title":"Surgical treatment and reconstruction for central giant cell granuloma of the jaws: A review of 18 cases","volume":"37","author":"Tosco","year":"2009","journal-title":"J Craniomaxillofac Surg"},{"key":"R5-20250925","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1053\/joms.2002.33241","article-title":"The surgical treatment of central giant cell granuloma of the mandible","volume":"60","author":"Bataineh","year":"2002","journal-title":"J Oral Maxillofac Surg"},{"key":"R6-20250925","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/jop.12730","article-title":"Central giant cell lesion of the jaws: An updated analysis of 2270 cases reported in the literature","volume":"47","author":"Chrcanovic","year":"2018","journal-title":"J Oral Pathol Med"},{"key":"R7-20250925","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/jop.12937","article-title":"Clinical factors associated with the recurrence of central giant cell lesions","volume":"48","author":"Chrcanovic","year":"2019","journal-title":"J Oral Pathol Med"},{"key":"R8-20250925","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jcms.2016.11.011","article-title":"Pharmacological and surgical therapy for the central giant cell granuloma: A long-term retrospective cohort study","volume":"45","author":"Schreuder","year":"2017","journal-title":"J Craniomaxillofac Surg"},{"key":"R9-20250925","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.otohns.2007.05.006","article-title":"Comparison of approaches for oral cavity cancer resection: Lip-split versus visor flap","volume":"137","author":"Cilento","year":"2007","journal-title":"Otolaryngol Head Neck Surg"},{"key":"R10-20250925","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0030-4220(82)90297-3","article-title":"Central giant cell granuloma of the mandible. 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